Novel .ALPHA.-Glucosidase Inhibitors, CKD-711 and CKD-711a Produced by streptomyces sp. CK-4416. II. Biological Properties.

Abstract

during the bioactive material screening for antibacterial agent. Their inhibitory activities were studied and compared with those of acarbose in vitro and in vivo with animals. In in vitro study, CKD-711 showed similar effects to acarbose on porcine intestinal maltase and sucrase, IC50s of than CKD-711 against all the enzymes tested. In rat fed on starch and sucrose meals, the dose of CKD-711 which reduced the postprandial blood glucose increment by 50 percent in comparison to control rats (ED50) were 3.07 and 1.15mg/kg, respectively, and acarbose had ED50s of 1.94 and 1.15mg/kg, respectively. CKD-711 and CKD-711a also showed antibacterial activity against Comamonas terrigena.

Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

“…Their half-maximal inhibitory dose (IC 50 ) was 9.50 and 1.624 µg GAE/mL, respectively ( Figure 1). The efficacy of the IBPP fraction is also supported by its lower IC 50 value compared to that of acarbose, which ranged from 36.0 to 107.3 µg/mL [50,51]. Green tea, oolong tea, and black tea had IC 50 values of 10.02, 1.38, and 2.25 µg/mL, respectively [52,53].…”

A comprehensive review of glycosylated bacterial natural products

“…Both compounds also selectively inhibited the growth of the Gram negative bacteria Comamonas terrigena but displayed no other antibacterial/antifungal effects. 1342 …”

Simultaneous anti-diabetic and anti-vascular calcification activity of Nocardia sp. UTMC 751

“…According to our knowledge, there exist only few reports on the anti‐diabetic activities of rare Actinomycetes FBEA (Kwon et al . ; Wang et al . ).…”

“…), Acarbose from Actinoplanes utahensis (Kwon et al . ; Wang et al . ), adiposin‐1 from Streptomyces calvus (Truscheit et al .…”