“…Other 1,4-benzodiazepine-based CCK 2 antagonists based on the paradigm of compound L-365,260 [23] were compound GR 199114X [26] which lacks a charged functionality, compounds L-736,380 [27] and Z-360 [28] which contain acidic substituents, and compounds L-740,093 [29] and YF476 [30], which contain basic substituents. Consequently, McDonald et al [31] have reported the synthesis of series of 1,3,4-benzotriazepine-based CCK 2 R antagonists which are achiral and maintained selectivity over CCK 1 R. Further, they reported optimization of 1,3,4-benzotriazepine-based CCK 2 R antagonists so as to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion [32]. CCK 2 R is a seven-transmembrane spanning receptor that belongs to the superfamily of GPCR's.…”