Novel accessory skull bone in fetal rats after exposure to aspirin

Mitala, Joseph; Boardman, James P.; Carrano, Richard; Iuliucci, John D.

doi:10.1002/tera.1420300113

Cited by 11 publications

(3 citation statements)

References 9 publications

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“…Recently, Mitala et al (1984) reported that SD rat fetuses exposed to aspirin in utero showed an accessory skull bone, which was not confirmed in S1c:Wistar-KY rats of the present study. Recently, Mitala et al (1984) reported that SD rat fetuses exposed to aspirin in utero showed an accessory skull bone, which was not confirmed in S1c:Wistar-KY rats of the present study.…”

Section: Discussioncontrasting

confidence: 92%

“…Skeletal malformations observed were fused ribs and vertebral anomalies. Recently, Mitala et al (1984) reported that SD rat fetuses exposed to aspirin in utero showed an accessory skull bone, which was not confirmed in S1c:Wistar-KY rats of the present study. DePass and Weaver (1982) also indicated that there were some differences in effects of aspirin between Fisher 344 and Wistar strains.…”

Section: Discussioncontrasting

confidence: 92%

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Developmental Toxicity of Aspirin Prenatally Given to Rats: Assessment in Sic: Wistar‐KY Rats

Okamoto

Kihara

Tanimura

1988

Congenital Anomalies

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S1c:Wistar-KY rats were administered orally with 62.5, 125, 187.5 or 250 mg/kg aspirin suspended with 0.5 % CMC-Na on days 9-1 1 of gestation (plug t = day 0). Suppression of maternal weight gain and food consumption during treatment was observed at and over 187.5 mg/kg. At term, the fetal mortality increased at and over 187.5 mg/kg and the fetal weight was lowered at and over 125 mg/kg. Among 15 live fetuses at 250 mg/kg, 4 had external malformations. In the skeletal examination (double staining), skeletal anomalies increased at and over 187.5 mg/kg. The skeletal variations such as vertebral anomalies, fused costal cartilages and increased presacral vertebrae were often encountered and delayed ossification was also found at and over 125 mg/kg. The internal anomalies tended to increase at and over 187.5 mg/kg. The live birth rate was significantly lower at 187.5 mg/kg than that in controls, and all pups, except for 3 from a dam, died before weaning. At 125 mg/kg, the pivoting locomotion on day 7 post partum was poorer as compared with controls. The physical and functional development at 62.5 mg/kg was not changed. There were no significant effects on male offspring in the open-field, rotarod, under-water T-maze and avoidance learning tests. However, in the Biel T-maze test (9-10 weeks of age), the aspirin-treated groups showed more errors and the increased elapsed time on the 1st trial day than controls. These results indicate that aspirin may induce a slight learning defect on rat offspring even at the non-teratogenic dose and the Biel T-maze test is more sensitive than any other learning tests given in this study.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussioncontrasting

confidence: 92%

Developmental Toxicity of Aspirin Prenatally Given to Rats: Assessment in Sic: Wistar‐KY Rats

Okamoto

Kihara

Tanimura

1988

Congenital Anomalies

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“…In addition, with increasing reliance on medications to manage health issues, understanding the consequences of developing novel wormian bones may be a new concern. In a study by Mitalla et al [10], the fetuses of rats fed aspirin on day 10 of their gestation had a 43% incidence of developing an accessory bone within the nasofrontal suture compared to the control group. This staggering association of a wormian bone developing in an extremely rare location at such a high incidence with medication use warrants further study.…”

Section: Discussionmentioning

confidence: 99%

Hiding Within the Cracks: Case Report of Rare Sutural Bone Found at the Nasion

Edwards

Wang

Iwanaga

et al. 2017

Cureus

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Pathology such as skull fractures can be misdiagnosed in the presence of anatomical variations. One variant that has had little description in the literature are the sutural bones associated with the nasal bones. Herein, we describe a case of a rare sutural bone at the nasion, between the bones of the right nasal, frontal, and maxillary frontal process. To our knowledge, this is the first report of such a variant bone in this location, and such it should be considered by clinicians when evaluating patients for pathology in this region.

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Analysis of the nonsteroidal anti‐inflammatory drug literature for potential developmental toxicity in rats and rabbits

Cook¹,

Jacobson²,

Gao³

et al. 2003

Birth Defects Research Pt B

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This analysis of the non-clinical NSAID literature demonstrated a possible association between exposure to NSAIDs and developmental anomalies. The anomalies were similar for aspirin and for other NSAIDs, but effects occurred at a much lower incidence with non-aspirin NSAIDs than previously reported with aspirin. Such a finding is consistent with the concept that reversible inhibition of COX-1 and/or COX-2 by other NSAIDs would produce weaker developmental toxicity signals than aspirin. However, there were limitations of the evaluated studies: (1) there were very few robust International Conference on Harmonization-compliant studies conducted with NSAIDs in the published literature; (2) many of the studies were conducted at doses well below the maximum tolerated dose (MTD), where effects are rarely seen; and (3) numerous studies were conducted above the MTD, where reduced numbers of fetuses hampered detection of low-incidence findings. Although weak associations were observed, these limitations prevented us from definitively determining the presence or absence of a developmental toxicity signal from the existing body of NSAID data. Further exploration of this hypothesis will require assessing the potential association in animal models by using dose levels centered around the MTD.

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Novel accessory skull bone in fetal rats after exposure to aspirin

Cited by 11 publications

References 9 publications

Developmental Toxicity of Aspirin Prenatally Given to Rats: Assessment in Sic: Wistar‐KY Rats

Developmental Toxicity of Aspirin Prenatally Given to Rats: Assessment in Sic: Wistar‐KY Rats

Hiding Within the Cracks: Case Report of Rare Sutural Bone Found at the Nasion

Analysis of the nonsteroidal anti‐inflammatory drug literature for potential developmental toxicity in rats and rabbits

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