Novel 3D porous aerogels engineered at nano scale from cellulose nano fibers and curcumin: An effective treatment for chronic wounds

Jose, Jiya; Pai, Avinash R.; Gopakumar, Deepu A.; Dalvi, Yogesh Bharat; Rubi, V.; Bhat, Sarita G.; Pasquini, Daniel; Kalarikkal, Nandakumar; Thomas, Sabu

doi:10.1016/j.carbpol.2022.119338

Cited by 39 publications

(17 citation statements)

References 35 publications

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“…Additionally, the scaffolds were effective against inflammation due to their porous structure and cell adhesion. 84 The scaffolds’ vast surface area, mild degradability, low toxicity, and porous nature make them excellent for interacting with and regenerating soft tissue. 85 We conclude that chitosan-based BG scaffolds will be a reliable material for enhanced and early wound healing with stifled inflammation, which will be advantageous for chronic wound healing and soft tissue regeneration.…”

Section: Discussionmentioning

confidence: 99%

Bioceramic and polycationic biopolymer nanocomposite scaffolds for improved wound self-healing and anti-inflammatory properties: an in vitro study

2023

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Section: Discussionmentioning

confidence: 99%

Bioceramic and polycationic biopolymer nanocomposite scaffolds for improved wound self-healing and anti-inflammatory properties: an in vitro study

2023

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“…Curcumin has been shown to promote wound healing ( Jose et al, 2022 ). However, its water solubility and skin permeability are poor, which limits its local application ( Naz and Ahmad, 2015 ).…”

Section: Application Of a Nanocomposite Hydrogel Delivery System To D...mentioning

confidence: 99%

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

Tong

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Diabetic ulcer is a serious complication of diabetes. Compared with that of healthy people, the skin of patients with a diabetic ulcer is more easily damaged and difficult to heal. Without early intervention, the disease will become increasingly serious, often leading to amputation or even death. Most current treatment methods cannot achieve a good wound healing effect. Numerous studies have shown that a nanocomposite hydrogel serves as an ideal drug delivery method to promote the healing of a diabetic ulcer because of its better drug loading capacity and stability. Nanocomposite hydrogels can be loaded with one or more drugs for application to chronic ulcer wounds to promote rapid wound healing. Therefore, this paper reviews the latest progress of delivery systems based on nanocomposite hydrogels in promoting diabetic ulcer healing. Through a review of the recent literature, we put forward the shortcomings and improvement strategies of nanocomposite hydrogels in the treatment of diabetic ulcers.

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“…14 CNF has the potential to be used as the building block for multifunctional materials, such as aerogels, whose properties can be tuned by its three-dimensional network structure and its modifiable surface chemistry. 15 Being one of the major classes of biopolymer aerogels, 16 cellulose aerogels may find applications in several disciplines including medicine and tissue engineering, 17 sensors, 18 adsorbents, 19 drug and nutrient delivery, 20 and thermal insulation. 21 The low thermal conductivity of aerogels can be attributed to their low density and small pore sizes.…”

Section: ■ Introductionmentioning

confidence: 99%

Thermally Insulating Cellulose Nanofiber Aerogels from Brewery Residues

Heidari

Fathi

Hamdami

et al. 2023

ACS Sustainable Chem. Eng.

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Brewery spent grain (BSG), the main waste of the brewery industry, is often disposed of or sold as an animal feed at low prices, neglecting the potential for further valorization. In this work, BSG was used for the first time to produce cellulose nanofiber aerogels for green thermal insulating applications. Cellulose nanofibers (CNFs) were extracted from BSG through microfluidization with and without TEMPO-oxidation pretreatment to obtain bio-based building blocks for aerogels. The TEMPO-treated CNFs exhibited a finer diameter (5.4 nm) with a more homogeneous size distribution (2−10 nm) than that of nonoxidized samples. All of the produced aerogels demonstrated low densities (0.009−0.031 g/cm 3 ), low thermal conductivities (32.3−37.7 mW/mK), and a compressive Young's modulus in the range of 4−311 kPa. Unidirectional freezing and TEMPO-oxidation showed a distinct improvement in the thermal conductivity and mechanical properties of the aerogels compared to the random frozen samples. Specifically, the unidirectional frozen aerogel with the highest investigated CNF concentration of 3 wt % exhibited the lowest thermal conductivity (32.4 mW/mK), highest Young's modulus (311 kPa), and good thermal stability. These results show that the BSG-derived nanocellulose is a valuable resource for producing eco-friendly, biodegradable, and thermally insulating aerogels.

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Novel 3D porous aerogels engineered at nano scale from cellulose nano fibers and curcumin: An effective treatment for chronic wounds

Cited by 39 publications

References 35 publications

Bioceramic and polycationic biopolymer nanocomposite scaffolds for improved wound self-healing and anti-inflammatory properties: an in vitro study

Bioceramic and polycationic biopolymer nanocomposite scaffolds for improved wound self-healing and anti-inflammatory properties: an in vitro study

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

Thermally Insulating Cellulose Nanofiber Aerogels from Brewery Residues

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