Nouvelles C-Glucosylflavones chez Gentiana pedicellata

Chulia, Albert J.; Mariotte, Anne‐Marie

doi:10.1021/np50039a023

Cited by 15 publications

(6 citation statements)

References 11 publications

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“…Three luteolin- C -hexoside- O -di-hexosides ( 32 , 36 and 46) with the same UV pattern gave MS n spectra fragments with m / z 771, 609, and 447 that are specific for a deprotonated ion and its dehexosylated fragments followed by the further cleavage typical for C -glycosylflavones [57]. Possible examples are isoorientin-2″,4′-di- O -glucoside isolated from G. asclepiadea herb [23] and isoorientin-3″,6″-di- O -glucoside from G. pedicellata leaves [58]. Two compounds, 65 and 73, gave a similar MS pattern but the existence of a hypsochromic shift in band II of the UV spectra (λ max 348→328 nm) and increased retention times pointed to acylation of luteolin- C -hexoside- O -hexoside by a caffeic acid fragment [56].…”

Section: Resultsmentioning

confidence: 99%

Caucasian Gentiana Species: Untargeted LC-MS Metabolic Profiling, Antioxidant and Digestive Enzyme Inhibiting Activity of Six Plants

et al. 2019

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The members of Gentiana genus are widely distributed in the Caucasus region where they are used as phytoremedies, but they still have not been studied for their chemical composition and bioactivity. High-performance liquid chromatography with diode array and electrospray triple quadrupole mass detection (HPLC-DAD-ESI-QQQ-MS) was used to investigate metabolites of herb and roots of six gentians (Gentiana asclepiadea, G. cruciata, G. gelida, G. paradoxa, G. pneumonanthe, G. septemfida) grown in the Caucasus. In total, 137 compounds were found including three carbohydrates, 71 iridoid glycosides (mostly loganic acid), loganin, swertiamarin, gentiopicroside and sweroside derivatives, 40 flavones C-, O-, C,O-glycosides (such as luteolin, apigenin, chrysoeriol, and acacetin derivatives), two phenolic O-glycosides, five hydroxycinnamates, eight xanthones, and seven triterpene glycosides. Most of these compounds were identified in gentian samples for the first time. Quantitative differences were found in levels of seven iridoid glycosides, nine glycosylflavones, and two xanthones obtained by HPLC-DAD assay. The gentian extracts were evaluated for their radical-scavenging properties against DPPH and superoxide anion radicals, lipid peroxidation inhibition, and α-amylase/α-glycosidase inhibition. The herb extracts showed higher activity than root extracts. Positive correlations were found between the content of quantified phenolics and antioxidant and digestive enzymes inhibiting activity. The findings presented in our work suggest that the Caucasian gentians are a good source of bioactive phytocompounds with antioxidant and antidiabetic potential.

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Section: Resultsmentioning

confidence: 99%

Caucasian Gentiana Species: Untargeted LC-MS Metabolic Profiling, Antioxidant and Digestive Enzyme Inhibiting Activity of Six Plants

et al. 2019

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“…Nepalese species reveals, besides C- glucosylfiavones (2)(3)(4), the presence of loganin (1) in substantial quantities and of minor new iridoids, aryl derivatives of 1: 2'-p-coumaroyl-loganin (2), 2'feruloyl-loganin (3) and 2'-caffeoyl-loganm (4).…”

Section: However Our Investigation Onmentioning

confidence: 99%

Loganin and New Iridoid Glucosides inGentiana pedicellata

Garcia¹,

Chulia²

1986

Planta Med

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“…Consequently, compound 2 was identified as 7-O-feruloylorientin. Compounds 3-6 were identified as lutonarin [12], saponarin [16,17], isoorient [14,18] and luteolin [19], respectively, by comparing their physical and spectral data with those reported in literature and from chemical evidence.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant phenolic glucosides from Gentiana piasezkii

Shi

2006

Journal of Asian Natural Products Research

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An extract of Gentiana piasezkii afforded a new arbutin derivative 6'-O-vanilloylarbutin (1) and a new flavone-C-glucoside 7-O-feruloylorientin (2), together with four known flavonoids lutonarin (3), saponarin (4), isoorient (5) and luteolin (6). Their structures were established based on spectroscopic methods including 2D NMR (COSY and gHMBC) techniques. Compounds 1, 2, 5 and 6 were evaluated for the antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay system.

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Nouvelles C-Glucosylflavones chez Gentiana pedicellata

Cited by 15 publications

References 11 publications

Caucasian Gentiana Species: Untargeted LC-MS Metabolic Profiling, Antioxidant and Digestive Enzyme Inhibiting Activity of Six Plants

Caucasian Gentiana Species: Untargeted LC-MS Metabolic Profiling, Antioxidant and Digestive Enzyme Inhibiting Activity of Six Plants

Loganin and New Iridoid Glucosides inGentiana pedicellata

Antioxidant phenolic glucosides from Gentiana piasezkii

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