Nouveaux aspects du diabète

Potìer, Pierre; Sasaki, A.; Bakala, Jiří; Garcia-Alvarez, Maria Concepcion; Franck, G; Nhiri, Naïma; Wang, Q.; Ermolenko, Ludmila; Nguefeu, Y.; Calvo, F. L.; Gautier, J.F.

doi:10.1016/s0003-4509(05)82307-7

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…[ 2 ] It has been estimated that more than 200 million people are affected with diabetes worldwide. [ 3 ] Insulin and oral hypoglycemic agents are used in the treatment of diabetes mellitus, but these agents have some undesirable side-effects, which limit their therapeutic efficacy. [ 4 ] Medicinal plants have a traditional role in the cure, treatment, and prevention of a number of diseases, and their uses are considered safer than synthetic drugs.…”

Section: Introductionmentioning

confidence: 99%

The hypoglycemic effect of the aqueous extract of the fruits ofBalanites aegypticeain Alloxan-induced diabetic rats

Baragob¹,

Almalki²,

Shahid³

et al. 2014

Phcog Res

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Background:Balanites aegypticea is used medically for many purposes e.g. anti-spasmodic, stomach pain, malaria, and yellow fever. The extract of the fruit is also used to reduce the blood glucose levels.Objectives:The objective of this study was to investigate the hypoglycemic effects of the aqueous extract of the fruits of the Balanites aegypticea in alloxan-induced diabetic rats.Materials and Methods:Twenty-five adult male Vistar rats were used in this study. The rats were randomly collected and divided into 5 groups (5 rats in each group). The untreated rats (negative control group) received basal diet and tap water only for 15 days. The experimental rats became diabetic by intraperitoneal injection of alloxan (150 mg/kg body weight). The fruit of Balanites aegypticea was powdered, extracted, and dried using organic solvents. The diabetic rats received aqueous extract 200 mg/kg, 400 mg/kg, and 800 mg/kg, respectively, for 2 weeks. Plasma glucose levels were measured by using Glucose GOD-PAP method through spectrophotometer.Results:The results showed that 800 mg/kg aqueous extract decrease significantly the plasma glucose level (P ≤ 0.05) in diabetic rats, and there is a considerable gain in body weight (P ≤ 0.05) compared to the diabetic control group. Four-hundred mg/kg aqueous extract has a mild effect on body weights and plasma glucose levels, while 200 mg/kg aqueous extract has no significant effect on plasma glucose level and a little effect on body weight.Conclusions:The results of the presented study revealed that the aqueous extract of Balanites aegypticea has hypoglycemic properties. It can decrease the plasma glucose level and can improve weight in diabetic experimental animals.

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Section: Introductionmentioning

confidence: 99%

The hypoglycemic effect of the aqueous extract of the fruits ofBalanites aegypticeain Alloxan-induced diabetic rats

Baragob¹,

Almalki²,

Shahid³

et al. 2014

Phcog Res

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“…[1] In muscle and fat cells, the uptake of circulating glucose depends on the insulin-stimulated translocation of the glucose transporter (GLUT) to the cell surface. [23]…”

Section: Introductionmentioning

confidence: 99%

Effects of physical training on the immune system in diabetic rats

Crespilho¹,

Leme²,

Mello³

et al. 2010

Int J Diab Dev Ctries

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Aims:This study aims to investigate the influence of physical training on the immune system of diabetic rats.Materials and Methods:Adult male Wistar rats were distributed into Sedentary Control (SC), Trained Control (TC), Sedentary Diabetic (SD) and Trained Diabetic (TD) groups were used. Diabetes was induced by alloxan (32 mg/bw-i.v.). Training protocol consisted of swimming, at 32 ± 1°C, one hour/day, five days/week, supporting an overload equivalent to 5% of the body weight, during four weeks. At the end of the experiment the rats were sacrificed by decapitation and blood samples were collected for glucose, insulin, albumin, hematocrit determinations, total and differential leukocyte counting. Additionally, liver samples for glycogen analyses were obtained.Results:The results were analyzed by one way at a significance level of 5%. Diabetes reduced blood insulin, liver glycogen stores and increased blood glucose and neutrophil count. Physical training restored glycemia, liver glycogen levels, neutrophils and lymphocytes count in diabetic rats.Conclusions:In summary, physical training was able to improve metabolic and immunological aspects in the experimental diabetic rats.

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A History of Drug Discovery

Chast¹

2008

The Practice of Medicinal Chemistry

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Nouveaux aspects du diabète

Cited by 6 publications

References 12 publications

The hypoglycemic effect of the aqueous extract of the fruits ofBalanites aegypticeain Alloxan-induced diabetic rats

The hypoglycemic effect of the aqueous extract of the fruits ofBalanites aegypticeain Alloxan-induced diabetic rats

Effects of physical training on the immune system in diabetic rats

A History of Drug Discovery

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