A History of Drug Discovery

Chast, François

doi:10.1016/b978-0-12-374194-3.00001-9

Cited by 12 publications

(4 citation statements)

References 231 publications

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“…Although model structures for salvarsan have been elucidated recently, the exact composition of salvarsan is still unknown; despite that fact, it has been used widely in humans. With the addition of mercury and bismuth, salvarsan remained the standard remedy for syphilis until it was replaced by penicillin after World War II …”

Section: Introductionmentioning

confidence: 99%

Metallodrugs in Medicinal Inorganic Chemistry

2014

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Section: Introductionmentioning

confidence: 99%

Metallodrugs in Medicinal Inorganic Chemistry

2014

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“…Despite advancements in our understanding of GCs' mechanism of action and potential side effects and development of new drugs, our knowledge about their side effects, e.g. cardiovascular accidents, neural and gastrointestinal disorders, myopathies, hyperglycemia, and dyslipidemia, remains insufficient (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoids-Induced Hypertension: The Prevalence and Risk Factors

Kimiamehr¹,

Haghighi²,

Arabi³

et al. 2017

hmj

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Introduction: Despite benefits in the treatment of most autoimmune and inflammatory diseases, glucocorticoids (GCs) have proved side effects including hypertension, diabetes, osteoporosis and lipid disorders. Determining the risk factors for hypertension can facilitate the identification of high-risk individuals and lead to effective control of the side effects. The present study aimed to determine the risk factors for hypertension in individuals receiving high-dose GCs. Methods: This prospective study recruited 140 adults (age>18 years) requiring prednisolone or equivalent more than 30mg daily for at least three months. The participants' blood pressure was monitored every month and correlations between the incidence of hypertension and variables such as serum calcium levels, weight, underlying diseases, body mass index (BMI), and folic acid use were investigated by repeated measure analysis. Results: While none of the subjects were hypertensive at baseline, 55 patients (39.28%) developed hypertension during the course of the study. Baseline weight and BMI, cumulative GC dose, family history of hypertension, and age were significantly higher in hypertensive patients. Conclusion: High BMI, male gender, elderly, family history of hypertension may have impact on development of hypertension in patients taking GCs.

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“…As long as we are honest with our patients about our current state of knowledge, I think not. Drug use has always been an integral part of human life, 5 helping to alleviate life's various physical, emotional and existential pains. Antidepressants are no different in this respect.…”

mentioning

confidence: 99%

Rational antidepressant use

Dunleavy

2018

BJPsych Bull

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A History of Drug Discovery

Cited by 12 publications

References 231 publications

Metallodrugs in Medicinal Inorganic Chemistry

Metallodrugs in Medicinal Inorganic Chemistry

Glucocorticoids-Induced Hypertension: The Prevalence and Risk Factors

Rational antidepressant use

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