Notice of Retraction and Replacement: Hofmann et al. Effect of intranasal oxytocin administration on psychiatric symptoms: A meta-analysis of placebo-controlled studies. Psychiatry Research. 2015;228:708-714

Hofmann, Stefan G.; Fang, Angela; Brager, Daniel N.

doi:10.1016/j.psychres.2016.10.055

Cited by 3 publications

(3 citation statements)

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“…However, some recent studies (e.g., Nave, Camerer & McCullough, 2015;Lane et al, 2015;Radke & de Bruijn, 2015;Hofmann, Fang & Brager, 2016) have failed to replicate some of the positive effects associated with OXT, raising concerns that previous studies were underpowered and/or that publication bias has resulted in the selective publication of positive findings (Lane, Luminet, Nave, & Mikolajczak, 2016). This, combined with some evidence that OXT can increase negative responses, such as schadenfreude (Shamay-Tsoory, Fischer, Dvash, Harari, Perach-Bloom & Levkovitz, 2009), has cast doubt on the role of OXT in promoting prosocial behaviors.…”

Section: Empathy For Fearmentioning

confidence: 99%

Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear

et al. 2017

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Oxytocin (OXT) has previously been implicated in a range of prosocial behaviors such as trust and emotion recognition. Nevertheless, recent studies have questioned the evidence for this link. In addition, there has been relatively little conclusive research on the effect of OXT on empathic ability and such studies as there are have not examined the mechanisms through which OXT might affect empathy, or whether OXT selectively facilitates empathy for specific emotions. In the current study, we used eye-tracking to assess attention to socially relevant information while participants viewed dynamic, empathy-inducing video clips, in which protagonists expressed sadness, happiness, pain or fear. In a double-blind, within-subjects, randomized control trial, 40 healthy male participants received 24 IU intranasal OXT or placebo in two identical experimental sessions, separated by a 2-week interval. OXT led to an increase in time spent fixating upon the eye-region of the protagonist's face across emotions. OXT also selectively enhanced self-reported affective empathy for fear, but did not affect cognitive or affective empathy for other emotions. Nevertheless, there was no positive relationship between eye-gaze patterns and affective empathy, suggesting that although OXT influences eye-gaze and may enhance affective empathy for fear, these two systems are independent. Future studies need to further examine the effect of OXT on eye-gaze to fully ascertain whether this can explain the improvements in emotional behavior.

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Section: Empathy For Fearmentioning

confidence: 99%

Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear

et al. 2017

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“…Clinical trials of IN OT with demonstration of target engagement (i.e., demonstrated activation of a proposed therapeutic mechanism at a clinically effective dose) are needed. 196 In addition, given publication bias of positive IN OT findings, 197 poor reproducibility of effects, 198 and retractions of seemingly promising meta-analytic findings, 199,200 caution in recommending IN OT for patients with stress-related disorders is warranted. Improved research standards including increased statistical power and reporting on trials without expected results are needed before IN OT can be utilized as a first-line treatment for stress-related disorders.…”

Section: Clinical Applications and Future Directionsmentioning

confidence: 99%

Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities

Sippel

Allington²,

Pietrzak

et al. 2017

Chronic Stress

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Novel pharmacotherapies that improve outcomes for individuals with stress-related psychiatric disorders are needed. The neurohormone oxytocin (OT) is a promising candidate given its influence on the social–emotional brain. In this review, we present an overview of evidence supporting OT’s utility for treating major depressive disorder and posttraumatic stress disorder. We first discuss endogenous OT, which research suggests is not yet a reliable biomarker of stress-related disorders. Second, we review effects of intranasal (IN) OT on processes relevant to stress-related disorders in healthy populations (anhedonia, reward processing, psychosocial stress reactivity, fear/anxiety, and social behavior) and their neurobiological mechanisms (e.g., the salience network and hypothalamic–pituitary–adrenal axis). Third, we present the sparse but promising findings from clinical populations, followed by discussion of critical moderating variables to consider in the service of maximizing the therapeutic potential of OT (e.g., patient sex and child maltreatment). We also identify heterogeneous findings and limitations of existing research, including reliance on single-dose studies in psychiatrically healthy samples and unanswered questions regarding the effectiveness of IN drug delivery and dosing schedules. Well-controlled multidose studies including women and measures of potentially moderating variables are sorely needed and would inform our understanding of the utility of OT for preventing and treating stress-related psychiatric disorders.

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“…Although is not a new article, and was recently retracted (Hofmann et al, 2016), there are several reasons this letter deserves attention. First, while they concluded that IN-OT had robust effects on several psychiatric symptoms, our analysis suggests that all effects were non-significant.…”

Section: Discussionmentioning

confidence: 99%

Coding Errors Lead to Unsupported Conclusions

Williams¹,

Bürkner²

2020

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Notice of Retraction and Replacement: Hofmann et al. Effect of intranasal oxytocin administration on psychiatric symptoms: A meta-analysis of placebo-controlled studies. Psychiatry Research. 2015;228:708-714

Cited by 3 publications

References 0 publications

Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear

Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear

Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities

Coding Errors Lead to Unsupported Conclusions

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