Note Phospholipase A2 Inhibition by Alkaloid Compounds from Phellodendron amurense Bark

Bonté, Frédéric; Dumas, Marc; Saunois, Alex; Meybeck, Alain

doi:10.1076/phbi.37.1.77.6323

Pharmaceutical Biology

1999

DOI: 10.1076/phbi.37.1.77.6323

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Note Phospholipase A2 Inhibition by Alkaloid Compounds from Phellodendron amurense Bark

Frédéric Bonté¹,

Marc Dumas²,

Alex Saunois³

et al.

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Cited by 2 publications

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“…Previous studies reported that PHE has anti-inflammatory effect and it may be due to its ability to suppress the cellular immune response [3][4][5] . This pharmacological effect also manifests as inhibiting-phospholipase A2 activity [6] . Noteworthily, PHE produces a marked effect in many types of inflammation, including bacterial vaginosis in mice [7] , acute kidney injury in sepsis rats [8] , inflammatory response of BV2 microglia induced by Lipopolysaccharide (LPS) [9] and the Reactive Oxygen Species (ROS)-mediated inflammatory response in zebrafish embryo [10] .…”

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Potential Targets and Mechanisms of Phellodendrine in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking

Liu¹

2022

IJPS

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Liu: Mechanisms of Phellodendrine in the Treatment of Diabetes MellitusPhellodendrine is a Phellodendri Cortex-derived isoquinoline alkaloids, has been shown to have various activities, especially hypoglycemic effect in mice, predicting its medicinal value on diabetes mellitus. To further understand the pharmacological effect of phellodendrine on diabetes mellitus, network pharmacological techniques have been used to elaborate the involved mechanisms. 84 common target molecules were screened, based on the chemical structure of phellodendrine molecule and disease database. These proteins were enriched in insulin resistance, insulin secretion and inflammatory response, mainly focus on the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, mitogen-activated protein kinase signaling pathway and interleukin-17 signaling pathway. Moreover, enrichment analysis suggested that the targets of phellodendrine such as phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha and mitogen-activated protein kinases 8 were associated with coronavirus disease 2019. To verify the results, molecular docking technique was used to evaluate the interaction between phellodendrine and key targets in the signaling pathway. The calculated binding energy indicates that phellodendrine can form stable complex with insulin receptor, mitogen-activated protein kinases 8, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha and glycogen synthase kinase 3 beta. These data suggest that phellodendrine should be beneficial for treatment of diabetes mellitus.

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Potential Targets and Mechanisms of Phellodendrine in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking

Liu¹

2022

IJPS

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The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos

Huang

Tian

et al. 2016

Life Sciences

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Note Phospholipase A2 Inhibition by Alkaloid Compounds from Phellodendron amurense Bark

Cited by 2 publications

References 5 publications

Potential Targets and Mechanisms of Phellodendrine in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking

Potential Targets and Mechanisms of Phellodendrine in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking

The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos

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