Not Wasting a Crisis: How Geriatrics Clinical Research Can Remain Engaged During <scp>COVID</scp>‐19

Goh, Eileen Fabia; Tan, Cai; Pek, Kalene; Leong, Siyun; Wong, Wan Ling; Lim, Wee Shiong

doi:10.1111/jgs.16569

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…The inclusion of these patients in therapeutic trials is complex. 21 It can be assumed that the cytokine storm could be greater than during the first contamination, leading to more serious and more frequently lethal forms. In the three cases reported here, the second episode was fatal in each patient.…”

Section: Discussionmentioning

confidence: 99%

“…If the risk of recurrence is confirmed, it will be crucial to analyze the risk factors (comorbidities, undernutrition, lymphopenia, and weak immune reaction with a low or even negative serology) but also their severity. The inclusion of these patients in therapeutic trials is complex 21 . It can be assumed that the cytokine storm could be greater than during the first contamination, leading to more serious and more frequently lethal forms.…”

Section: Discussionmentioning

confidence: 99%

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Recurrence or Relapse of COVID‐19 in Older Patients: A Description of Three Cases

Lafaie

Célarier

Goethals

et al. 2020

J American Geriatrics Society

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BACKGROUND: COVID-19 has infected millions of people worldwide, particularly in older adults. The first cases of possible reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported in April 2020 among older adults. DESIGN/SETTING: In this brief report, we present three geriatric cases with two episodes of SARS-CoV-2 infection separated by a symptom-free interval. PARTICIPANTS: The participants of this brief report are three cases of hospitalized geriatric women. MEASUREMENTS/RESULTS: We note clinical and biological worsening during the second episode of COVID-19 for all three patients. Also, there is a radiological aggravation. The second episode of COVID-19 was fatal in all three cases. CONCLUSION: This series of three geriatric cases with COVID-19 diagnosed two times apart for several weeks questions the possibility of reinfection with SARS-CoV-2. It raises questions in clinical practice about the value of testing for SARS-CoV-2 infection again in the event of symptomatic reoccurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrence or Relapse of COVID‐19 in Older Patients: A Description of Three Cases

Lafaie

Célarier

Goethals

et al. 2020

J American Geriatrics Society

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“…These included migrant workers [477][478][479]481], the general public [476], surgeons [480], and dentists [475]. Research activities during the pandemic were discussed [482][483][484][485], looking at the current gaps in knowledge and how to further progress the research about COVID-19 [483,484], as well as the impact of the pandemic on the conduct of research [482,485]. Some articles were about medical ethics [486][487][488][489], exploring ethics in general [487], inequities in healthcare among the population [489], and the allocation of resources for critical care in this pandemic [486,488].…”

Section: Others (15 Articles)mentioning

confidence: 99%

One Year on: An Overview of Singapore’s Response to COVID-19—What We Did, How We Fared, How We Can Move Forward

Anand

Shuy

Lee³

et al. 2021

IJERPH

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Background—One year has passed since the first COVID-19 case in Singapore. This scoping review commemorates Singaporean researchers that have expanded the knowledge on this novel virus. We aim to provide an overview of healthcare-related articles published in peer-reviewed journals, authored by the Singapore research community about COVID-19 during the first year of the pandemic. Methods—This was reported using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) protocol. It included healthcare-related articles about COVID-19 published between 23 January 2020 and 22 January 2021 with a Singapore-affiliated author. MEDLINE, Embase, Scopus, Web of Science, CINAHL, PsycINFO, Google Scholar, and local journals were searched. The articles were screened independently by two reviewers. Results—The review included 504 articles. Most of the articles narrated the changes to hospital practice (210), while articles on COVID-19 pathology (94) formed most of the non-narrative papers. Publications on public health (61) and the indirect impacts to clinical outcomes (45) were other major themes explored by the research community. The remaining articles detailed the psychological impact of the pandemic (35), adaptations of medical education (30), and narratives of events (14). Conclusion—Amidst a resurgence of community cases involving variant COVID-19 strains, the resources from the research community will provide valuable guidance to navigate these uncertain times.

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COVID-19 in the Geriatric Population

Narang

Sharma

Mohindra

et al. 2022

COVID-19: Effects in Comorbidities and Special Populations

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The second pandemic of the 21st century, the Coronavirus Disease – 2019, has kept the entire world on its toes. The virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), seems to have an entire deck of tricks up its sleeve. The brash and acerbic disease course has left the entire world gasping. A sour understanding of the virus evolves, our knowledge base at this point is rather nascent. While the rate of infection is highest among the younger age groups, the Case Fatality Rate seems to be five to seven-fold higher in patients aged 65 years and above. With unforeseen restraints and stern preventive policies in place worldwide, the core principles of Geriatrics seem to have taken a backseat. Social distancing might’ve turned into social suppression, and the phenomena of immunosenescence and frailty leave our elderly population with an oligosymptomatic illness, which is, on many occasions, neglected on a personal, familial or even healthcare level, thus, erring on the gravity of the illness. Patients and medical personnel in hospice facilities and long-term care facilities (LTCFs) face unique and unprecedented challenges. With atypical presentations, multimorbidities, and multiple psychosocial facets, the Coronavirus Disease-2019 presents a rather interesting challenge in the care and management of older adults.

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Not Wasting a Crisis: How Geriatrics Clinical Research Can Remain Engaged During COVID‐19

Cited by 3 publications

References 7 publications

Recurrence or Relapse of COVID‐19 in Older Patients: A Description of Three Cases

Recurrence or Relapse of COVID‐19 in Older Patients: A Description of Three Cases

One Year on: An Overview of Singapore’s Response to COVID-19—What We Did, How We Fared, How We Can Move Forward

COVID-19 in the Geriatric Population

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