Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats

Song, Jingjing; Hou, Xintong; Hu, Xinyu; Lu, Chengyu; Liu, Chungang; Wang, Juan; Liu, Wei; Teng, Lirong; Wang, Di

doi:10.1016/j.cbi.2015.10.001

Cited by 34 publications

(14 citation statements)

References 45 publications

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“…; Song et al . ). This points to the possibility that piglets after antibiotic infusion may have a higher risk of neuropsychiatric disorders than normal piglets.…”

Section: Discussionmentioning

confidence: 97%

Antibiotics‐induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets

Gao

et al. 2018

Journal of Neurochemistry

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The evidence of gut microbiota-mediated modulation of brain function has been widely recognized from studies using germ-free rodents or animals with oral antibiotic-induced microbiota depletion. Since the large intestine harbors greater numbers and more diverse of microbes than in the small intestine, large intestinal microbiota may play a crucial role in the modulation of brain function. In this study, a large intestinal microbiota-targeted strategy was used to investigate the impact of large intestinal microbiota on brain function. Twelve piglets (12.08 ± 0.28 kg) fitted with a T-cannula at the distal ileum were fed a standard diet and randomly assigned to two groups (n = 6) for ileal infusion of either saline or antibiotics. After 25 days of infusion, ileal and fecal microbiota, serum amino acids and neurotransmitters, and hypothalamic transcriptomics were analyzed. While the antibiotic infusion did not change the proximal ileal microbial composition, it markedly altered the fecal microbial composition and increased aromatic amino acid (AAAs) metabolism (p < 0.05), suggesting the infusion specifically targeted large intestinal microbes. Concentrations of AAAs were likewise decreased in the blood and hypothalamus (p < 0.05) by antibiotic infusion. Antibiotic infusion further decreased concentrations of hypothalamic 5-hydroxytryptamine (5-HT) and dopamine, in line with AAAs being their precursors. An up-regulation in gene expressions of neurotransmitter transporters and synthetases was observed (q < 0.001). In conclusion, the distalileal-antibiotic infusion altered neurotransmitter expression in the porcine hypothalamus and this effect occurred simultaneously with changes in both the large intestinal microbiota, and AAAs in the large intestine, blood and hypothalamus. These findings indirectly indicate that large intestinal microbiota affects hypothalamic neurotransmitter expressions. Read the Editorial Highlight for this article on page 208.

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“…; Song et al . ). This points to the possibility that piglets after antibiotic infusion may have a higher risk of neuropsychiatric disorders than normal piglets.…”

Section: Discussionmentioning

confidence: 97%

Antibiotics‐induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets

Gao

et al. 2018

Journal of Neurochemistry

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“…Furthermore, these antidepressant-like effects were blocked by pretreatment with the dopamine D 1 receptor antagonist SCH23390 (0.05 mg/kg) and D 2/3 receptor antagonist sulpiride (50 mg/kg) [ 18 ], confirming that the antidepressant-like effects of Apocynum venetum L. occur through actions on the dopaminergic system. This mechanism of action is important because clinically effective antidepressant drugs, such as clomipramine (tricyclic antidepressant) and fluoxetine (selective serotonin reuptake inhibitor), activate the serotonergic and noradrenergic systems in the long term and parallelly also activate the mesolimbic dopamine system producing their antidepressant effects [ 102 – 104 ].…”

Section: Antidepressant-like Effects Of Flavonoids In Plant Extracmentioning

confidence: 99%

Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents

Germán-Ponciano

Rosas-Sánchez

Rivadeneyra-Domínguez

et al. 2018

Scientifica

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Flavonoids are phenolic compounds found commonly in plants that protect them against the negative effects of environmental insults. These secondary metabolites have been widely studied in preclinical research because of their biological effects, particularly as antioxidant agents. Diverse flavonoids have been studied to explore their potential therapeutic effects in the treatment of disorders of the central nervous system, including anxiety and depression. The present review discusses advances in the study of some flavonoids as potential antidepressant agents. We describe their behavioral, physiological, and neurochemical effects and the apparent mechanism of action of their preclinical antidepressant-like effects. Natural flavonoids produce antidepressant-like effects in validated behavioral models of depression. The mechanism of action of these effects includes the activation of serotonergic, dopaminergic, noradrenergic, and γ-aminobutyric acid-ergic neurotransmitter systems and an increase in the production of neural factors, including brain-derived neurotrophic factor and nerve growth factor. Additionally, alterations in the function of tropomyosin receptor kinase B and activity of the enzyme monoamine oxidase A have been reported. In conclusion, preclinical research supports the potential antidepressant effects of some natural flavonoids, which opens new possibilities of evaluating these substances to develop complementary therapeutic alternatives that could ameliorate symptoms of depressive disorders in humans.

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“…Protective herbal therapy is considered a reliable method that can reduce the toxicity of Semen Strychni and increase its use in clinical practice. Radix Paeoniae Alba has been reported to have wide-ranging pharmacological activities on the nervous system [ 3 ] and has been combined with Semen Strychni in the clinic and in the prescription of Chinese patent drugs, such as Gu Ci tablets, Shu Luo Yang Gan pills, and Qi Wei Tang. Radix Paeoniae Alba reportedly decreases the toxic effects and increases the therapeutic effects of Semen Strychni [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of P‐Glycoprotein Modulation by Semen Strychni Combined with Radix Paeoniae Alba

Liu

Guan

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Semen Strychni has been extensively used as a Chinese herb, but its therapeutic window is narrowed by the strong toxicity of the compound, which limits its effectiveness. Radix Paeoniae Alba has been reported to reduce the toxic effects and increase the therapeutic effects of Semen Strychni, but the underlying mechanism remains unknown. This research aimed to explore the mechanism through which P-glycoprotein (P-gp) is modulated by Semen Strychni combined with Radix Paeoniae Alba in vitro. An MTT assay was used to study cytotoxicity in an MDCK-MDR1 cell model. Rh123 efflux and accumulation were measured to assess P-gp function. The expression levels of MDR1 mRNA and P-gp protein in MDCK-MDR1 cells were investigated. A P-gp ATPase activity assay kit was applied to detect the effect on P-gp ATPase activity. Semen Strychni combined with Radix Paeoniae Alba could induce P-gp-mediated drug transport by inhibiting brucine and strychnine transport in MDCK-MDR1 cells, enhancing the P-gp efflux function, upregulating the P-gp expression and MDR1 mRNA levels, and stimulating P-gp ATPase activity.

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Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats

Cited by 34 publications

References 45 publications

Antibiotics‐induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets

Antibiotics‐induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets

Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents

Mechanisms of P‐Glycoprotein Modulation by Semen Strychni Combined with Radix Paeoniae Alba

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