Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents

Germán-Ponciano, León Jesús; Rosas-Sánchez, Gilberto Uriel; Rivadeneyra-Domínguez, Eduardo; Rodríguez‐Landa, Juan Francisco

doi:10.1155/2018/2963565

Cited by 37 publications

(38 citation statements)

References 114 publications

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“…The relative contents of three phenylpropanoids, four alkaloids, two flavones and one anthocyanin, flavonol, and isoflavone were significantly different between the three treatment groups (HBG, XQG, and ZQG) and the control group (DHG) ( Figure 6). The phenylpropanoid content varied greatly among the flavedo (outer colored part of the peel) of the different groups [30], and the change in phenylpropanoid content was accompanied by changes in color and antioxidant activity [22,31,32]. Alkaloids were also the main component of citrus peels and have bioactive functions, such as antifungal and antioxidant activity [33].…”

Section: Differential Metabolites Between the Three Treatment Groups mentioning

confidence: 99%

Metabolomics Analysis of the Peels of Different Colored Citrus Fruits (Citrus reticulata cv. ‘Shatangju’) During the Maturation Period Based on UHPLC-QQQ-MS

Wang

Huang

et al. 2020

Molecules

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Citrus is a globally consumed fruit with great popularity. Mandarin (Citrus reticulata cv. ‘Shatangju’) is a local variety, and its planting area and yield are the greatest regarding fruit tree planting in Guangdong Province, China. However, its resistance to Huanglongbing (HLB) is weak. After infection by HLB, the fruits cannot develop normally. In this study, four kinds of fruits were classified as HBG, XQG, ZQG, and DHG, according to the color of their peels. The metabolomes of the three abnormally colored groups (HBG, XQG, and ZQG) and the normally colored group (DHG) were compared using a UPLC-QQQ-MS-based metabolomics approach. In total, 913 metabolites were identified and classified into 23 different categories, including phenylpropanoids and flavonoids; among them, 215 (HBG, 177; XQG, 124; and ZQG, 62) metabolites showed differential accumulation in the three comparison groups (HBG/XQG/ZQG versus DHG). A total of 2 unique metabolites, O-caffeoyl maltotriose and myricetin were detected only in DHG samples. When comparing HBG with DHG, there were 109 decreased and 68 increased metabolites; comparing XQG with DHG, there were 88 decreased and 36 increased metabolites; comparing ZQG with DHG, 41 metabolites were decreased, and 21 metabolites were increased. Metabolic pathway enrichment analysis of these differential metabolites showed significant enrichment of the “phenylpropanoid biosynthesis” pathway in all comparison groups. The hierarchical cluster analysis of the differential metabolites of the four groups showed a clear grouping patterns. The relative contents of three phenylpropanoids, four flavonoids, two alkaloids, one anthocyanin, and two other metabolites were significantly different between each comparison group. This study might provide fundamental insight for the isolation and identification of functional compounds from the peels of citrus fruit infected with HLB and for in-depth research on the effect of HLB on the formation of fruits pigment and the development of HLB-resistant citrus varieties.

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Section: Differential Metabolites Between the Three Treatment Groups mentioning

confidence: 99%

Metabolomics Analysis of the Peels of Different Colored Citrus Fruits (Citrus reticulata cv. ‘Shatangju’) During the Maturation Period Based on UHPLC-QQQ-MS

Wang

Huang

et al. 2020

Molecules

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“…Flavonoids are the most widely studied active metabolites (for a broad review of research, see German-Ponciano et al [30]). Genistein is an isoflavone that can cross the blood-brain barrier in mice [31] and rats [32].…”

Section: Flavonoids With Antidepressant Effects: Preclinical Researchmentioning

confidence: 99%

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

García-Ríos¹,

Mora-Pérez²,

Ramos-Molina³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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Depression and anxiety currently rank as the second and fifth most common causes worldwide of years lived with disability-a reality that has intensified the search for new treatments. There are many studies of herbal extracts and secondary metabolites from plants used in traditional medicine due to their antidepressant and anxiolytic properties. Clinical and preclinical studies about some of the mechanisms of action of metabolites like alkaloids, terpenes, flavonoids, and sterols, among others, have documented effects similar to those produced by clinically effective drugs. These metabolites have shown anxiolytic and antidepressant effects in various experimental models of anxiety by interacting with γ-aminobutyric acid subtype A receptors (GABA A-receptors) and by stimulating the serotonergic, noradrenergic, and dopaminergic neurotransmitter systems. These pharmacological effects can be attributed to plant metabolites that share structural similarities with monoamines, which allow them to bind to receptors. The objective of this chapter is to summarize the various mechanisms of action that have been identified in secondary metabolites with anxiolytic and antidepressant properties. Terpenes, alkaloids, flavonoids, and sterols can interact at different levels of the neurotransmission systems involved in the neurobiology of anxiety and depression, suggesting their potential for treating these mental illnesses.

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“…У кавової кислоти виявлено антидепресивну та анксіолітичну дію, пов'язану з модуляцією α-1A-адренорецепторів [28]. Зрештою, добре відома на сьогодні модуляція ГАМК-ергічної системи флавоноїдами [29].…”

Section: результати та їх обговоренняunclassified

The influence of goutweed (aegopodium podagraria l.) Extract and tincture on the behavioural reactions Of mice against the background of caffeine-sodium benzoate

Tovchiga¹,

Shtrygol²,

Balia³

2018

Klìn. farm.

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На теперішній час значну увагу привертають фітопрепарати та компоненти раціону, що містять гідроксикоричні кислоти. Їх значною кількістю характеризуються препарати надземної частини яглиці звичайної (Aegopodium podagraria L.), які виявляють помірну психотропну та сприятливу метаболічну дію. Мета дослідження-охарактеризувати психотропні ефекти екстракту та настойки яглиці звичайної на тлі кофеїн-бензоату натрію у мишей. Матеріали та методи. Досліди проведені на рандомбредних мишах після курсового внутрішньошлункового введення екстракту яглиці (100 мг/кг та 1 г/кг) і настойки яглиці (1 та 5 мл/кг). На тлі кофеїн-бензоату натрію в дозі 10 мг/кг доочеревинно визначали поведінкові реакції в тесті відкритого поля. Зміни тривожності та депресивності вивчали в тестах піднесеного хрестоподібного лабіринту (ПХЛ) і підвішування за хвіст відповідно на тлі високої дози кофеїн-бензоату натрію 120 мг/кг доочеревинно. Результати. У тесті відкритого поля настойка яглиці в дозі 5 мл/кг усувала стимулювальну дію кофеїну на рухову активність мишей, настойка в дозі 1 мл/кг та екстракт в обох дозах не впливали на неї. Препарати яглиці не зменшували дослідницьку активність у даному тесті та виявляли нейтральність щодо емоційних та вегетативних реакцій або сприяли їх зменшенню. В тесті ПХЛ екстракт в обох дозах і настойка яглиці в дозі 5 мл/кг знижували тривожність на тлі кофеїну, настойка підвищувала рухову активність. У тесті підвішування за хвіст кофеїн зменшував іммобільність мишей, екстракт у дозі 100 мг/кг не впливав на цей ефект, у дозі 1 г/кг-усував його. Настойка в обох дозах спричиняла подальше зменшення часу іммобільності на тлі кофеїну. Висновки. Екстракт та настойка яглиці звичайної не чинять несприятливого впливу на ЦНС за поєднання з психостимулятором кофеїном та здатні знижувати депресивність і тривожність на його тлі.

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Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents

Cited by 37 publications

References 114 publications

Metabolomics Analysis of the Peels of Different Colored Citrus Fruits (Citrus reticulata cv. ‘Shatangju’) During the Maturation Period Based on UHPLC-QQQ-MS

Metabolomics Analysis of the Peels of Different Colored Citrus Fruits (Citrus reticulata cv. ‘Shatangju’) During the Maturation Period Based on UHPLC-QQQ-MS

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

The influence of goutweed (aegopodium podagraria l.) Extract and tincture on the behavioural reactions Of mice against the background of caffeine-sodium benzoate

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