Not always a commensal: A case of mastitis by Corynebacterium amycolatum

Borde, Kalyani; Rao, V. Arjuna; Shah, Milap; Pavani, N; Anand, Mridu

doi:10.1016/j.idcr.2020.e00728

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…We found that neither the bovine C. urogenitale nor C. endometrii genomes code for a pili cluster. Both C. amycolatum and C. aurimucosum have recently been reported as opportunistic pathogens causing a variety of infections throughout the human body [42][43][44], including the urinary [44,45] and vaginal [46] tracts. Furthermore, pili play an essential role in uropathogenic E. coli UTI infections in the human urinary tract [47].…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium phoceense, resident member of the urogenital microbiota?

et al. 2021

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Corynebacterium phoceense is a Gram-positive species previously isolated from human urine. Although other species from the same genus have been associated with urinary tract infections, C. phoceense is currently believed to be a non-pathogenic member of the urogenital microbiota. Prior to our study, only two isolates were described in the literature, and very little is known about the species. Here, we describe C. phoceense UFMG-H7, the first strain of this species isolated from the urine of healthy cattle. The genome for this isolate was produced and compared to the two other publicly available C. phoceense as well as other Corynebacterium genome assemblies. Our in-depth genomic analysis identified four additional publicly available genome assemblies that are representatives of the species, also isolated from the human urogenital tract. Although none of the strains have been associated with symptoms or disease, numerous genes associated with virulence factors are encoded. In contrast to related Corynebacterium species and Corynebacterium species from the bovine vaginal tract, all C. phoceense strains examined code for the SpaD-type pili suggesting adherence is essential for its persistence within the urinary tract. As the other C. phoceense strains analysed were isolated from the human urogenital tract, our results suggest that this species may be specific to this niche.

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Section: Discussionmentioning

confidence: 99%

Corynebacterium phoceense, resident member of the urogenital microbiota?

et al. 2021

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“…Although Corynebacterium amycolatum ( Collins et al, 1988 ) is commonly found in the normal microbiome of the human skin and mucosal membranes ( Gladysheva et al, 2022 ), this microorganism is now regarded as a potential multidrug-resistant opportunistic pathogen, especially in nosocomial environments and particularly when it comes to immunocompromised patients ( Konstantinidis and Tiedje, 2005 ; Carvalho et al, 2018 ; Borde et al, 2020 ). It has already been described as the causative agent of serious infections in both humans and animals.…”

Section: Introductionmentioning

confidence: 99%

“…It has already been described as the causative agent of serious infections in both humans and animals. Focusing on human infections, C. amycolatum has been described as the underlaying agent of endocarditis ( Konstantinidis and Tiedje, 2005 ), mastitis ( Borde et al, 2020 ), ear infections ( Sengupta et al, 2015 ), and neonatal sepsis ( Berner et al, 1997 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, this technology is not always accessible to all clinical microbiology laboratories, in particular in developing countries. Besides, monitoring the phenotypic profiles of antimicrobial susceptibility is of fundamental importance, as several isolates have demonstrated multiple resistance to antibiotics, in particular to penicillins, clindamycin, aminoglycosides, and fluoroquinolones ( Sánchez Hernández et al, 2003 ; Carvalho et al, 2018 ; Borde et al, 2020 ; Dragomirescu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Pan-genomic analysis of Corynebacterium amycolatum gives insights into molecular mechanisms underpinning the transition to a pathogenic phenotype

et al. 2022

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Corynebacterium amycolatum is a nonlipophilic coryneform which is increasingly being recognized as a relevant human and animal pathogen showing multidrug resistance to commonly used antibiotics. However, little is known about the molecular mechanisms involved in transition from colonization to the MDR invasive phenotype in clinical isolates. In this study, we performed a comprehensive pan-genomic analysis of C. amycolatum, including 26 isolates from different countries. We obtained the novel genome sequences of 8 of them, which are multidrug resistant clinical isolates from Spain and Tunisia. They were analyzed together with other 18 complete or draft C. amycolatum genomes retrieved from GenBank. The species C. amycolatum presented an open pan-genome (α = 0.854905), with 3,280 gene families, being 1,690 (51.52%) in the core genome, 1,121 related to accessory genes (34.17%), and 469 related to unique genes (14.29%). Although some classic corynebacterial virulence factors are absent in the species C. amycolatum, we did identify genes associated with immune evasion, toxin, and antiphagocytosis among the predicted putative virulence factors. Additionally, we found genomic evidence for extensive acquisition of antimicrobial resistance genes through genomic islands.

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Bacteria Associated with Granulomatous Lobular Mastitis and the Potential for Personalized Therapy

Yuan

et al. 2020

Journal of Investigative Surgery

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Not always a commensal: A case of mastitis by Corynebacterium amycolatum

Cited by 7 publications

References 12 publications

Corynebacterium phoceense, resident member of the urogenital microbiota?

Corynebacterium phoceense, resident member of the urogenital microbiota?

Pan-genomic analysis of Corynebacterium amycolatum gives insights into molecular mechanisms underpinning the transition to a pathogenic phenotype

Bacteria Associated with Granulomatous Lobular Mastitis and the Potential for Personalized Therapy

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