Pan-genomic analysis of Corynebacterium amycolatum gives insights into molecular mechanisms underpinning the transition to a pathogenic phenotype

Jesus, Hendor N. R.; Rocha, Danilo J P G; Ramos, Rui A. R.; Silva, Artur M. S.; Brenig, Bertram; Goés-Neto, Aristóteles; Costa, Mateus Matiuzzi da; Soares, Siomar C.; Azevedo, Vasco; Aguiar, Eric Roberto Guimarães Rocha; Martínez-Martínez, Luiz; Ocampo, Alain; Alibí, Sana; Dorta, Alexis; Pacheco, Luis Gustavo Carvalho; Navas, Jesús

doi:10.3389/fmicb.2022.1011578

Cited by 3 publications

(1 citation statement)

References 76 publications

(88 reference statements)

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“…It has been isolated from blood cultures, cellulitis, wounds, endocarditis, and peritonitis (250,253). A recent pangenomic study of drug resistant and commensal isolates of C. amycolatum gave insight into the core genome and the transition from commensal to pathogenic phenotype (262).…”

Section: Amycolatummentioning

confidence: 99%

Beyond the usual suspects: emerging uropathogens in the microbiome age

Moreland,

Choi,

Geaman

et al. 2023

Front. Urol.

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The advent of sensitive enhanced culture (metaculturomic) and culture-independent DNA-based (metagenomic) methods has revealed a rich collection of microbial species that inhabit the human urinary tract. Known as the urinary microbiome, this community of microbes consists of hundreds of distinct species that range across the entire phylogenetic spectrum. This new knowledge clashes with standard clinical microbiology laboratory methods, established more than 60 years ago, that focus attention on a relatively small subset of universally acknowledged uropathogens. Increasing reports support the hypothesis that this focus is too narrow. Single uropathogen reports are common in women with recurrent urinary tract infection (UTI), although wider disruption of their urinary microbiome is likely. Typical “UTI” symptoms occur in patients with “no growth” reported from standard culture and sometimes antibiotics improve these symptoms. Metaculturomic and metagenomic methods have repeatedly detected fastidious, slow growing, and/or anaerobic microbes that are not detected by the standard test in urine samples of patients with lower urinary tract symptoms. Many of these microbes are also detected in serious non-urinary tract infections, providing evidence that they can be opportunistic pathogens. In this review, we present a set of poorly understood, emerging, and suspected uropathogens. The goal is to stimulate research into the biology of these microbes with a focus on their life as commensals and their transition into pathogens

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Section: Amycolatummentioning

confidence: 99%

Beyond the usual suspects: emerging uropathogens in the microbiome age

Moreland,

Choi,

Geaman

et al. 2023

Front. Urol.

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Draft genome sequences of four Corynebacterium amycolatum strains isolated from female urine samples

Kula,

Chilton,

Damaso

et al. 2024

Microbiol Resour Announc

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Comparative bioinformatics analysis of antimicrobial resistance gene pool in the genomes of representatives of genus Corynebacterium

Kulshan,

Bugaeva,

Soboleva

et al. 2023

BRSMU

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Currently, multidrug resistance of bacterial infectious agents poses a serious threat to the global public health. The following Corynebacterium strains are of special importance for infections, including hospital-acquired ones: C. amycolatum, C. urealyticum, C. striatum, C. jeikeium, C. aurimucosum, C. genitalium that are resistant to the broad spectrum of antimicrobial drugs. The study was aimed to conduct bioinformatics analysis of the pool of antimicrobial resistance genes in the published genomes of some members of the genus Corynebacterium. The data on the whole genome nucleotide sequences of 22 Corynebacterium isolates readily available from NCBI GenBank were assessed. Bioinformatics analysis of the whole genome sequences conducted in order to search for antimicrobial resistance genes in the specified genomes was performed using the PATRIC online resource. It was found that the genomes provided comprised various combinations of 25 antimicrobial drug resistance genes. Amino acid substitutions in GyrA (positions 87, 88 and 91) were revealed in some Corynebacterium strains, through which quinolone/fluoroquinolone resistance could be realized.

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Pan-genomic analysis of Corynebacterium amycolatum gives insights into molecular mechanisms underpinning the transition to a pathogenic phenotype

Cited by 3 publications

References 76 publications

Beyond the usual suspects: emerging uropathogens in the microbiome age

Beyond the usual suspects: emerging uropathogens in the microbiome age

Draft genome sequences of four Corynebacterium amycolatum strains isolated from female urine samples

Comparative bioinformatics analysis of antimicrobial resistance gene pool in the genomes of representatives of genus Corynebacterium

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