Nosocomial transmission of dengue fever via needlestick. An occupational risk

Morgan, Caitlin; Paraskevopoulou, Stavroula-Maria; Ashley, Elizabeth A.; Probst, Fey; Muir, David

doi:10.1016/j.tmaid.2015.03.016

Cited by 6 publications

(7 citation statements)

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“…The current paradigm is that dengue is passed from human to human by the bite of an infected mosquito. However, reports of nonvector transmission are steadily escalated . Most of these nonvector DENV infections are underreported even in endemic countries.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, DENV is transmitted to humans via the bite of the infectious female mosquitos of the genus Aedes , mainly A. aegypti . Recently, nonvector DENV transmission has been reported in the literature, including intravenous and/or intradermal inoculation, mucocutaneous exposure, blood transfusion, hematopoietic stem cell transplantation (HSCT), solid organ transplantation, needlestick in patient care or laboratory accident, vertical transmission from mother to infant, and breastfeeding . This line of evidence suggests that DENV can be transmitted through direct exposure through blood/body fluid exposure, leading to disease.…”

mentioning

confidence: 99%

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Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells

Hsu

Lai

et al. 2019

Transfusion

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BACKGROUND Dengue virus (DENV) is a significant threat to public health in tropical and subtropical regions, where the frequency of human migration is increasing. Transmission of DENV from donors to recipients after hematopoietic stem cell transplantation has been steadily described. However, the underlying mechanisms remain unclear. STUDY DESIGN AND METHODS Freshly isolated bone marrow (BM) was subjected to DENV infection, followed by multicolor fluorescence‐activated cell sorting (FACS) analysis. Virus in supernatants was collected and analyzed by plaque assay. RESULTS DENV‐1 to DENV‐4 could effectively infect freshly obtained BM and produced infectious virus. DENV infection did not change the quantitative population of hematopoietic stem and progenitor cells (HSPCs), megakaryocytic progenitor cells (MkPs) and megakaryocytes. Additionally, DENV antigen, nonstructural protein 1, was enriched in HSPCs and MkPs of DENV infected marrow cells. CD34+, CD133+, or CD61+ cells sorted out from BM were not only the major contributing targets facilitating the DENV infection directly but also facilitated the spread of DENV into other cells when cocultured. CONCLUSION Results suggest that DENV can efficiently infect HSPCs, which might jeopardize the recipients if DENV‐infected cells were subsequently used. We therefore raise the need for DENV screening for both the donors and recipients of hematopoietic stem cell transplantation, especially for donors exposed to endemic areas, to mitigate DENV infection in immunocompromised recipients.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells

Hsu

Lai

et al. 2019

Transfusion

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“…These will not be discussed as there is no clear demonstration of nosocomial or person-to-person spread, although there have been reports of transmission of Dengue virus through needlestick injuries 19. Lesser-known VHF viruses in this family are the Omsk , Kyasanur and Alkhurma haemorrhagic fever viruses , which are thought to spread from bites of infected ticks, although other methods of transmission have been postulated (see table 1).…”

Section: Flaviviridaementioning

confidence: 99%

Viral haemorrhagic fever in children

MacDermott

Herberg

2016

Arch Dis Child

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Viral haemorrhagic fevers (VHFs) are currently at the forefront of the world's attention due to the recent Zaire ebolavirus epidemic in West Africa. This epidemic has highlighted the frailty of the world's public health response mechanisms and demonstrated the potential risks to nations around the world of imported cases of epidemic diseases. While imported cases in children are less likely, the potential for such a scenario remains. It is therefore essential that paediatricians are aware of and prepared for potential imported cases of tropical diseases, VHFs being of particular importance due to their propensity to cause nosocomial spread. Examining the four families of viruses—Filoviridae, Arenaviridae, Bunyaviridae and Flaviviridae, we describe the different types of VHFs, with emphasis on differentiation from other diseases through detailed history-taking, their presentation and management from a paediatric perspective.

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“…4 This method of identifying healthcare-associated infections (HAIs) has been considered the gold standard for hospital surveillance, 4 and few studies have validated metrics utilizing administrative data for HAIs. 3,[5][6][7] The purpose of this study was to determine the utility of the CVC-related bloodstream infection metric as a proxy for the NHSN CLABSI metric. The University of Iowa Hospitals and Clinics (UIHC) is a 732-bed, tertiary-care, teaching hospital.…”

Section: Acknowledgmentsmentioning

confidence: 99%

“…Nosocomial acquisition of dengue fever has been reported to occur by needle-stick injury, 5 mucocutaneous exposure to blood, 6 blood transfusion, 7 and transplantation 6 . In this study, we describe cases of hospital-acquired vector-transmitted dengue disease in a setting of high prevalence of the disease.…”

mentioning

confidence: 98%