Nosocomial sepsis-induced late onset thrombocytopenia in a neonatal tertiary care unit

Charoo, Bashir Ahmad; Iqbal, Javeed; Iqbal, Qazi; Mushtaq, Sheikh; Bhat, Abdul Wahid; Nawaz, Imtiyaz

doi:10.1016/s1658-3876(09)50024-6

Cited by 33 publications

(35 citation statements)

References 22 publications

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“…This has been shown in other studies as well. 8 Thrombocytopenia occurs more frequently in association with certain factors like sepsis, ELBW, severe birth asphyxia, babies born to pre-eclamptic mothers and low birth weight babies and this was seen in our study as well. Though it is less common in babies with meconium aspiration, hyper bilirubinemia, mild birth asphyxia and respiratory distress syndrome, in our study moderate thrombocytopenia was found in 13.0% cases (16/115) and severe thrombocytopenia was found in 2.6% (3/115) in this group as well.…”

Section: Discussionsupporting

confidence: 81%

Incidence of thrombocytopenia in the neonatal intensive care unit

Gupta¹,

Mathai

Kanitkar

2011

Medical Journal Armed Forces India

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Section: Discussionsupporting

confidence: 81%

Incidence of thrombocytopenia in the neonatal intensive care unit

Gupta¹,

Mathai

Kanitkar

2011

Medical Journal Armed Forces India

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“…7 Studies conducted by Charoo BA et al and Robert and Murray1 also state that neonatal thrombocytopenia was more common among low birth weight babies. 18 Gupta AK et al stated that LBW babies showed statistically significant thrombocytopenia due to their limited ability to compensate for accelerated destruction of platelets. 19 Placental transport of IgG from maternal to fetal circulation increases with maturity and this transport is hampered in low birth weight babies which make them more prone for sepsis.…”

Section: Neonatal Factorsmentioning

confidence: 99%

“…In studies conducted by Nandyal et al, Charoo BA et al, prematurity was associated with severe thrombocytopenia. 4,10,18 Among multiple neonatal risk factors, sepsis was the most commonest cause of neonatal thrombocytopenia which was found in 97 (48.5%) babies and was associated with severe neonatal thrombocytopenia. The percentage of sepsis among thrombocytopenic babies in nandyal et al study was 22.2%, Gupta et al study was 42% and khalessi et al study was 24.1%.…”

Section: Neonatal Factorsmentioning

confidence: 99%

Study of risk factors of neonatal thrombocytopenia

Tirupathi

Swarnkar

Vagha

2016

Int J Contemp Pediatr

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Background: Neonatal thrombocytopenia (platelet count < 1.5 lac/µl) is the commonest haematological abnormality encountered in neonatal intensive care unit (NICU). Thrombocytopenia if not detected can result in devastating complications. Determining the risk factors of thrombocytopenia enables us to prevent the inevitable and irreversible complications. The present study highlights the pattern, severity and risk factors of neonatal thrombocytopenia in our hospital.Methods: Prospective observational study was conducted on 200 neonates with thrombocytopenia admitted in NICU of our hospital. Maternal and neonatal risk factors were recorded. Neonates were grouped based on the severity of thrombocytopenia. The risk factors were compared with severity of thrombocytopenia.Results: 200 neonates with thrombocytopenia were divided into three groups based on severity of thrombocytopenia. 81% of babies had moderate to severe thrombocytopenia. The most common maternal predisposing factors were pregnancy induced hypertension (PIH), premature rupture of membranes (PROM) and anemia.62.5% babies were low birth weight babies and they had severe thrombocytopenia. 56% babies had late onset neonatal thrombocytopenia and 44% had early onset thrombocytopenia. The most common neonatal risk factors were sepsis in 48.5% babies and birth asphyxia in 20% babies.Conclusions: The severity of neonatal thrombocytopenia in our NICU was moderate to severe type. PIH, PROM and anemia were the commonest maternal risk factors. Preterm and low birth weight babies had severe thrombocytopenia. Sepsis and birth asphyxia were the commonest neonatal risk factors. Birth asphyxia was associated with early onset neonatal thrombocytopenia and sepsis was associated with late onset thrombocytopenia. Severe thrombocytopenia can be used as a prognostic indicator in sick neonates.

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“…No significant differences were seen in platelet and platelet indices in relationship with gestational age. [6][7][8][9][10][11][12][13][14] There is paucity of literature on this role of platelet parameters in neonatal sepsis in Indian subcontinent. This study was done for evaluation of platelet indices (platelet count, PDW, MPV) in neonatal septicaemia, in rural Indian population.…”

Section: Resultsmentioning

confidence: 99%

“…Few studies have documented significant changes in platelet indices in neonatal sepsis as well as older children and adults. [6][7][8][9][10][11][12][13][14][15][16][17][18] Still, there is no clear consensus, so more studies are needed on this subject. At present, there is paucity of literature regarding platelet indices in neonatal sepsis.…”

Section: Introductionmentioning

confidence: 99%