Incidence of thrombocytopenia in the neonatal intensive care unit

Gupta, Ashutosh; Mathai, Sheila; Kanitkar, Madhuri

doi:10.1016/s0377-1237(11)60048-8

Cited by 20 publications

(26 citation statements)

References 11 publications

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“…The percentage of sepsis among thrombocytopenic babies in nandyal et al study was 22.2%, Gupta et al study was 42% and khalessi et al study was 24.1%. 4,3,7 In studies conducted by Patil et al, Basil and Zaccheaus et al, sepsis was associated with severe thrombocytopenia which was similar to the results in our study. 10,16,21 Septicemia leads to thrombocytopenia due to both decreased production and increased consumption of platelets and hence results usually in severe thrombocytopenia.…”

Section: Neonatal Factorssupporting

confidence: 91%

“…In studies conducted by Nandyal et al and Gupta et al, birth asphyxia was associated with severe thrombocytopenia which was similar to present study. 3,4 NNH and MAS were associated with mild to moderate neonatal thrombocytopenia and it was statistically significant (P value 0.0001). In Gupta et al study and Nandyal et al study, NNH and MAS were associated with mild thrombocytopenia which was similar to our study.…”

Section: Neonatal Factorsmentioning

confidence: 87%

“…In studies conducted by khalessi et al, Ghamdi et al and Gupta et al, mild thrombocytopenia was more common. 3,7,8 In a study conducted by Nandyal et al on 99 neonates, severe thrombocytopenia was present in 65.6% of babies and in Bonifacio et al study, severe thrombocytopenia was present in 51% of babies. 9 The results in our study were similar to studies conducted by Nandyal et al and Bonifacio et al The high prevalence of moderate and severe thrombocytopenia in our study was probably because of higher proportion of septicemic babies in our NICU which is also a referral centre.…”

Section: Demographic Featuresmentioning

confidence: 93%

“…In Gupta et al study and Nandyal et al study, NNH and MAS were associated with mild thrombocytopenia which was similar to our study. 3,4 Another study conducted by Boskabadi et al on incidence of thrombocytopenia in idiopathic hyperbilirubinemic newborns also showed that 86.4% of babies with NNH had mild thrombocytopenia. 22 In a study conducted by Khera et al on incidence of thrombocytopenia following phototherapy in hyperbilirubinemic neonates, an association of phototherapy as a cause of thrombocytopenia in hyperbilirubinemic neonates was established.…”

Section: Neonatal Factorsmentioning

confidence: 97%

“…2 Multiple disease processes can cause thrombocytopenia in neonates and these can be classified as early onset (<72 hours) and late onset (>72 hours) neonatal thrombocytopenia. 3 The important causes of thrombocytopenia in neonates are sepsis, birth asphyxia, prematurity, intra-uterine growth retardation, hyperbilirubinemia, respiratory distress syndrome, meconium aspiration syndrome and low birth weight. Apart from platelet counts, bleeding manifestations depend on underlying ailments.…”

Section: Introductionmentioning

confidence: 99%

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Study of risk factors of neonatal thrombocytopenia

Tirupathi

Swarnkar

Vagha

2016

Int J Contemp Pediatr

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Background: Neonatal thrombocytopenia (platelet count < 1.5 lac/µl) is the commonest haematological abnormality encountered in neonatal intensive care unit (NICU). Thrombocytopenia if not detected can result in devastating complications. Determining the risk factors of thrombocytopenia enables us to prevent the inevitable and irreversible complications. The present study highlights the pattern, severity and risk factors of neonatal thrombocytopenia in our hospital.Methods: Prospective observational study was conducted on 200 neonates with thrombocytopenia admitted in NICU of our hospital. Maternal and neonatal risk factors were recorded. Neonates were grouped based on the severity of thrombocytopenia. The risk factors were compared with severity of thrombocytopenia.Results: 200 neonates with thrombocytopenia were divided into three groups based on severity of thrombocytopenia. 81% of babies had moderate to severe thrombocytopenia. The most common maternal predisposing factors were pregnancy induced hypertension (PIH), premature rupture of membranes (PROM) and anemia.62.5% babies were low birth weight babies and they had severe thrombocytopenia. 56% babies had late onset neonatal thrombocytopenia and 44% had early onset thrombocytopenia. The most common neonatal risk factors were sepsis in 48.5% babies and birth asphyxia in 20% babies.Conclusions: The severity of neonatal thrombocytopenia in our NICU was moderate to severe type. PIH, PROM and anemia were the commonest maternal risk factors. Preterm and low birth weight babies had severe thrombocytopenia. Sepsis and birth asphyxia were the commonest neonatal risk factors. Birth asphyxia was associated with early onset neonatal thrombocytopenia and sepsis was associated with late onset thrombocytopenia. Severe thrombocytopenia can be used as a prognostic indicator in sick neonates.

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Section: Neonatal Factorssupporting

confidence: 91%

Section: Neonatal Factorsmentioning

confidence: 87%

Section: Demographic Featuresmentioning

confidence: 93%

Section: Neonatal Factorsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Study of risk factors of neonatal thrombocytopenia

Tirupathi

Swarnkar

Vagha

2016

Int J Contemp Pediatr

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Neonatal thrombocytopenia—causes and outcomes following platelet transfusions

et al. 2018

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We evaluated the causes for neonatal thrombocytopenia (NT), the duration of NT, and the indications of platelet transfusions (PT) by means of a retrospective cohort study over a 23-year period. Neonates with NT were identified via ICD-10 code D69.6. Of 371 neonates (1.8/1000 live births) with NT, the majority (312; 84.1%) had early onset thrombocytopenia, and 282 (76%) were preterm born. The most frequent causes for NT were early and late onset sepsis and asphyxia. The mean duration of thrombocytopenia was 10.2 days and was negatively correlated (KK = − 0.35) with the number of PT. PT were given to 78 (21%) neonates, 38 (49%) of whom had very severe NT. The duration of NT was positively related to the severity of NT and the number of subsequent PT. A mortality rate of 10.8% was significantly associated with bleeding signs (p < 0.05) and correlated with increasing number of PT (p < 0.05) but not with the severity of NT (p = 0.4). In the case of relevant hemorrhage, PT did not influence the mortality rate (p = 0.09). All deaths followed neonatal sepsis.Conclusions: Prematurity and diagnoses including early and late onset sepsis and asphyxia were the most common causes of NT. Mortality was not associated with the severity of NT but increased with the number of PT. What is Known: • The causes for neonatal thrombocytopenia (NT) are well known. • The effects of platelet transfusions (PT) and its indications are still a matter of debate and recommendations differ widely. What is New: • The duration of NT is positively related to the severity of NT and the number of subsequent PT. • The mortality rate is not associated with the severity of NT but increases with increasing numbers of PT and in the case of relevant intraventricular hemorrhage (≥ grade II), PT does not influence the mortality rate.

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Approach to neonatal thrombocytopenia: immature platelet fraction has a major role

Kotwal

2011

Medical Journal Armed Forces India

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Incidence of thrombocytopenia in the neonatal intensive care unit

Cited by 20 publications

References 11 publications

Study of risk factors of neonatal thrombocytopenia

Study of risk factors of neonatal thrombocytopenia

Neonatal thrombocytopenia—causes and outcomes following platelet transfusions

Approach to neonatal thrombocytopenia: immature platelet fraction has a major role

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