Nosocomial outbreak of severe fever with thrombocytopenia syndrome among healthcare workers in a single hospital in Daegu, Korea

Viral shedding pattern of severe fever with thrombocytopenia syndrome virus in severely ill patients:A Prospective, Multicenter Study

“…Severe fever with thrombocytopenia syndrome is transmitted predominantly by tick bites and potentially human-to-human. Nosocomial and intrafamily transmission of SFTSV have been reported through contact with blood and secretions from patients [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33], which put the health-care workers and close family members involved inpatient care at risk for exposure. Transmission of SFTSV during aerosolgenerating medical procedures was also proposed as possible [15,16,19,28,36,37].…”

“…Human-to-human events of SFTSV have attracted urgent public health concern [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Research about SFTSV excretion from patient's body and PPEs application of HCWs against human-to-human transmission was sparsely investigated.…”

“…According to Bae et al, 28.8% of HCWs were infected SFTSV by contact with the severely ill SFTS patient, participation in administration of cardiopulmonary resuscitation, exposure to the patient's body uids and shorter individual hospital work experience were con rmed to be risk factors for SFTSV human-to-human. This study has underlined the importance of wearing appropriate personal protective equipment in treatment areas to SFTS patient [33]. Pharyngeal virus shedding may be a risk for SFTSV human-to-human of HCWs in conducting treatment of orotracheal intubation and cardiopulmonary resuscitation.…”

“…The SFTSV infection was primarily transmitted from infected tick to human. In addition to tick transmission, human-to-human transmission of SFTS had been widely reported and mostly caused by unprotected exposure to individuals with SFTS disease [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. A strong risk factor linked to human-tohuman SFTSV spread is contact with infected bodily uids.…”

Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development

“…Although there are accounts of nosocomial human-to-human transmission from infected individuals to healthcare providers and sporadic animal-to-human transmission [ 7 , 40 , 41 ], the primary route of infection is through a tick bite by an Asian longhorned tick ( Haemaphysalis longicornis ) [ 42 , 43 , 44 ]. The Asian longhorned tick functions as a vector and reservoir of SFTSV, maintaining the virus in the tick population via transovarial and transstadial transmission [ 45 ].…”