Current Status and Infection Control of Severe Fever with Thrombocytopenia Syndrome in Korea

Oh, Hyunjoo; Yoo, Jeong Rae; Kim, Mi-Sun; Heo, Sang Taek

doi:10.14192/kjicp.2022.27.1.18

Cited by 4 publications

(3 citation statements)

References 64 publications

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“…Although SFTS cases have been reported across South Korea, most occur in grassy, brushy, or wooded areas suitable for ticks, including Gyeonggi, Gangwon, and Gyeongbuk [ 19 ]. Notably, agricultural farmers, who have occupational risk factors associated with SFTS [ 12 , 20 , 21 ], are most likely to be exposed to ticks infected with Dabie bandavirus .…”

Section: Discussionmentioning

confidence: 99%

One-year mortality and morbidities of severe fever with thrombocytopenia syndrome compared with other diseases: A nationwide cohort study in South Korea

Heo,

Park

et al. 2024

PLoS Negl Trop Dis

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Background The long-term mortality and morbidity of patients with severe fever with thrombocytopenia syndrome (SFTS) remain unclear. Methods This retrospective cohort study was conducted using the National Health Insurance Service dataset on hospitalized patients with SFTS aged ≥20 years between 2016 and 2021 (n = 1,217). Each SFTS case was matched with three controls hospitalized for non-SFTS-related diseases using propensity score matching. The all-cause mortality of patients with SFTS was evaluated during the one-year follow-up and compared with that of controls. Post-discharge events were investigated to determine the effects of SFTS on post-acute sequelae. Results Finally, 1,105 patients with SFTS and 3,315 controls were included. Patients with SFTS had a higher risk of death during the one-year follow-up than that of controls (hazard ratio [HR], 2·26; 95% confidence interval [CI], 1·82–2·81). Thirty-day mortality was significantly higher in the SFTS group (HR, 3·99; 95% CI, 3·07–5·19) than in the control group. An increased risk of death after 31–365 days was observed among controls, though this difference was significant only among patients in their 80s (HR, 0·18; 95% CI, 0·06–0·57). For post-discharge events, patients in the SFTS group exhibited a higher risk of readmission (HR, 1·17; 95% CI, 1·04–1·32) and emergency room visit (HR, 2·32; 95% CI, 1·96–2·76) than those in the control group. Conclusion SFTS induces a higher risk of short-term mortality and post-acute sequelae in hospitalized patients during a one-year follow-up than non-SFTS-related diseases. Our results provide guidance for the management of SFTS.

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Section: Discussionmentioning

confidence: 99%

One-year mortality and morbidities of severe fever with thrombocytopenia syndrome compared with other diseases: A nationwide cohort study in South Korea

Heo,

Park

et al. 2024

PLoS Negl Trop Dis

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“…In terms of sex ratio, SFTS incidence was more common in the men included in this study. However, in Korea, SFTS was reported to be more prevalent in women [ 19 ]. Other studies, particularly from China, also reported that SFTS incidence was more common in women than in men.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic and Clinical Characteristics of Patients with Severe Fever with Thrombocytopenia Syndrome at Tertiary Hospital in Jeju for 10 years

et al. 2023

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Background Severe fever with thrombocytopenia syndrome (SFTS), which was first discovered in China in 2009, is an infectious disease with a high mortality rate, particularly in East Asia. This study aimed to investigate the epidemiological and clinical characteristics and risk factors for mortality by analyzing SFTS cases accumulated for up to ten years in Jeju, Korea. Materials and Methods Medical records of patients diagnosed with SFTS between March 2013 and August 2022 at a tertiary hospital in Jeju were analyzed retrospectively. We investigated data of patients with SFTS on the epidemiologic and clinical characteristics, laboratory findings, and administered treatments and compared the differences between fatal and non-fatal groups. Results We enrolled 91 SFTS-confirmed patients. The median age of patients was 62 years, and the fatality rate increased with age ( P = 0.004). Fever was the most common symptom (84.6%), and diarrhea (37.4%) was also present in some cases. The overall fatality rate was 10.9%. Dyspnea (20.0% vs. 0.0%, P = 0.009) and changes in mental status (70.0% vs. 11.0%, P <0.001) were more frequent in fatal cases. Risk factor assessment revealed that a high aspartate aminotransferase /alanine aminotransferase ratio (odds ratio [OR]: 39.568, 95% confidence interval [CI]: 1.479 – 1,058.639, P = 0.028) and elevated total bilirubin levels (OR: 53.037, 95% CI: 1.064 - 2,643.142, P = 0.046) were also significantly associated with fatal cases. Plasma exchange (40.7%) was the most commonly administered treatment. Conclusion SFTS has a high mortality rate; therefore, awareness of SFTS must be raised among physicians and citizens living in tick-inhabited areas, such as Jeju.

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“…According to data from the KDCA during 2013–2021, SFTSV infections in Jeju Island occurred mainly during the spring and summer seasons, in contrast with regions in the mainland, where SFTSV incidence was high during autumn. 20 Therefore, summer presents a high risk of SFTSV human infection in Jeju Island.…”

Section: Discussionmentioning

confidence: 99%

Coinfection of Severe Fever With Thrombocytopenia Syndrome Virus and Coxiella burnetii in Developmental Stage of Hard Ticks in Subtropical Region of Korea

et al. 2023

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Background Severe fever with thrombocytopenia syndrome virus (SFTSV) is transmitted through tick bites. Ticks are potential vectors for the bacterium Coxiella burnetii that causes Query fever. Here, we analyzed SFTSV and C. burnetii co-infection rates in ticks in rural areas of Jeju Island, South Korea. Methods Free ticks were collected from the natural environment of the island between 2016 and 2019, and SFTSV RNA was extracted. Additionally, ribosomal RNA gene sequencing was used to identify Coxiella species. Results Haemaphysalis longicornis was the most common tick species followed by H. flava . Tick number gradually increased from April, peaked in August, and was lowest in March. Of all the collected ticks, 82.6% (2,851/3,458) were nymphs, 17.9% (639/3,458) adults, and 0.1% (4/3,458) larvae. SFTSV-infected ticks comprised 12.6% of all ticks; their numbers were the lowest in November–December, increased from January, and were mostly identified in the adult stage during June–August. C. burnetii infections were detected in 4.4% of the SFTSV-infected H. longicornis ticks. C. burnetii co-infection was mainly observed in the nymph stage of H. longicornis , with the highest infection rate in January, followed by December and November. Conclusion Our findings suggest that Jeju Island has a high SFTSV and potential C. burnetii infection in ticks. This study provides important insights regarding SFTS and Q fever risk to humans in South Korea.

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Current Status and Infection Control of Severe Fever with Thrombocytopenia Syndrome in Korea

Cited by 4 publications

References 64 publications

One-year mortality and morbidities of severe fever with thrombocytopenia syndrome compared with other diseases: A nationwide cohort study in South Korea

One-year mortality and morbidities of severe fever with thrombocytopenia syndrome compared with other diseases: A nationwide cohort study in South Korea

Epidemiologic and Clinical Characteristics of Patients with Severe Fever with Thrombocytopenia Syndrome at Tertiary Hospital in Jeju for 10 years

Coinfection of Severe Fever With Thrombocytopenia Syndrome Virus and Coxiella burnetii in Developmental Stage of Hard Ticks in Subtropical Region of Korea

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