Epidemiologic and Clinical Characteristics of Patients with Severe Fever with Thrombocytopenia Syndrome at Tertiary Hospital in Jeju for 10 years

Kim, J.; Yoo, Jeong Rae; Kim, Misun; Oh, Hyunjoo; Heo, Sang Taek

doi:10.3947/ic.2023.0035

Cited by 1 publication

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From 2010 to 2019, a total of 13,824 SFTS cases were reported in mainland of China, with the nationwide average annual fatality rate reaching 5.2% [ 8 ]. In Japan and South Korea, the case fatality rates were higher at 35% and 16.3% respectively [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China

Sun,

Zhang,

Liu

et al. 2024

Emerging Microbes & Infections

View full text Add to dashboard Cite

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with an increasing annual incidence rate. In this case report, we presented two patients infected with the SFTS virus, suggesting a potential direct transmission route from camels to humans through blood contact. Both patients developed symptoms after engaging in the slaughtering of one sick camel, while their family members living in the same environment or co-diners remained unaffected. Subsequent detection revealed a high viral load of SFTS virus, reaching 10 10 viral RNA copies/ml, in the sample obtained from the sick camel. Metagenomic sequencing did not identify any other pathogens. The SFTS virus was successfully isolated from both patient and camel samples. The complete nucleotide sequences obtained from the infected patients demonstrated a remarkable 100% similarity to those found in the camel, and genetic evolution analysis classified the virus as genotype A. Additionally, partial sequences of the SFTS virus were identified in ticks captured from the camel rearing environment, however, these sequences showed only 95.9% similarity to those found in camel and humans. Furthermore, immunoglobulin M and immunoglobulin G antibodies were detected in serum samples collected from the patient. Our findings provide evidence that camel may serve as a competent reservoir for transmitting the SFTS virus to humans. Further in vitro investigations into SFTS virus infections in large animals are warranted to understand their role in viral maintenance and transmission.

show abstract

Section: Introductionmentioning

confidence: 99%