Nosocomial Outbreak of Pediatric Gastroenteritis Caused by CTX-M-14-Type Extended-Spectrum β-Lactamase-Producing Strains of Salmonella enterica Serovar London

Abstract

CTX-M-14-type extended-spectrum ␤-lactamase was first detected in Salmonella enterica serovar London strains which were isolated from three hospitalized pediatric patients with gastroenteritis. The isolates had pulsed-field gel electrophoresis patterns identical to those of the previously isolated antimicrobialsusceptible strains from community-acquired gastroenteritis, suggesting the susceptible clone acquired the resistance.

Serotyping and Antimicrobial Susceptibility of <i>Salmonella</i> spp.: Nationwide Multicenter Study in Korea

“…In Korea, a few isolates of TEM-52, CTX-M-14, and CTX-M-15 ESBL-producing Salmonella spp. were detected, of which CTX-M-15 was the most common, followed by CTX-M-14 (13,19,29,30). In the present study, 7 CTX-M-producing Salmonella isolates were identified.…”

“…All the Salmonella isolates were examined for the presence of bla CTX-M by PCR and direct sequencing using 4 primer sets (Table 1) (18,19). The PCR reaction was performed under the following conditions: 949 C for 5 min, followed by 35 cycles of 949 C for 30 s, 609 C for 30 s, and 729 C for 30 s, with a final extension at 729 C for 5 min.…”

Nosocomial Clustering of NDM-1-Producing Klebsiella pneumoniae Sequence Type 340 Strains in Four Patients at a South Korean Tertiary Care Hospital

“…ESBL phenotypes were positive only in strain E5026 and its transconjugant, and PABL activity was detected in all isolates ( Table 2). The presence of known MBLs (bla VIM , bla IMP , bla SPM-1 , bla GIM-1 , bla AIM-1 , bla SIM-1 , and bla NDM-1 ) (13, 24), ESBLs (bla TEM , bla SHV , and bla CTX-M ) (25), and PABL genes (17) were determined using PCR. We also aimed to detect ISAba125 and 16S rRNA methylase (armA) by using the published primers (7).…”

Case Report of Pediatric Gastroenteritis Due to CTX-M-15 Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serotype Enteritidis

“…A few isolates of TEM-25 and CTX-M-14 ESBL-producing Salmonella spp. have been reported in Korea [11,12]; however, prior to the present case, there had been no reports of ESBL production in S. enterica serotype Enteritidis.…”