Nosocomial lung infections in adult intensive care units

Hernández, Gónzalo; Rico, P.; Dı́az, Emili; Rello, Jordi

doi:10.1016/j.micinf.2004.05.019

Cited by 21 publications

(13 citation statements)

References 108 publications

(108 reference statements)

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“…It is the most common cause of death among nosocomial infections and is the primary cause of death in intensive care units (ICUs). 1 Pseudomonas aeruginosa is an important pathogen of nosocomial LRTI especially in ICUs and is commonly resistant to many antibiotics. 2 Multidrug-resistant (MDR) P. aeruginosa (resistant to at least three of the following antimicrobials: ceftazidime, imipenem, gentamicin and ciprofloxacin) are often isolated from nosocomial infections in ICUs.…”

Section: Introductionmentioning

confidence: 99%

Efflux pump genes and antimicrobial resistance of Pseudomonas aeruginosa strains isolated from lower respiratory tract infections acquired in an intensive care unit

et al. 2011

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The aim of this study was to determine the antimicrobial resistance rates and the resistance genes associated with efflux pumps of Pseudomonas aeruginosa strains isolated from the patients who acquired lower respiratory tract infection (LRTI) in intensive care unit (ICU). Fifty P. aeruginosa strains isolated from the lower respiratory tract specimens of the patients who acquired LRTIs in ICU were included in this study. P. aeruginosa strains were isolated from tracheal aspirate (27), bronchoalveolar lavage (14) and sputum (9). The susceptibilities of the isolates were investigated by the disk diffusion method. Multiplex PCR assay was carried out for the detection of 13 antibiotic-resistance genes. Antimicrobial resistance rates of the isolates were found high and the highest resistance rate of the isolates studied was determined against to mezlocillin (50%) followed by norfloxacin (48%), ciprofloxacin (46%), meropenem (40%). Fourty-three isolates (86%) were determined to carry one and more resistance genes. NfxB gene was most often determined in the genes that were investigated. The significant relation between the resistance to cefepime, piperacilline/tazobactam and the mexC gene, that between the resistance to mezlocillin, piperacilline/tazobactam, ceftazidime, cefepime and ampC genes, and that between the resistance to ciprofloxacin, norfloxacin and oprJ, oprN and nfxB genes was identified. Resistance caused by genes for carbapenemases, aminoglycoside-modifying enzymes and other mechanisms were not identified in this study. Understanding the prevalence and mechanism of antimicrobial resistance in P. aeruginosa may help to select empirical therapy for nosocomial LRTIs due to P. aeruginosa in our ICU.

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Section: Introductionmentioning

confidence: 99%

Efflux pump genes and antimicrobial resistance of Pseudomonas aeruginosa strains isolated from lower respiratory tract infections acquired in an intensive care unit

et al. 2011

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“…Da die Entwicklung neuer Antibiotika gegen multiresistente Erreger für die nächs-ten fünf bis zehn Jahre nicht absehbar ist, ist es notwendig, die momentan noch wirksamen Reserveantibiotika wie Carbapeneme und Polymyxin-Derivate mög-lichst rational und zurückhaltend einzusetzen [2,3,4,5].…”

Section: Vermeidung Von Antibiotika Resis Ten Zen: Antibioticstewardshipunclassified

Nosokomiale Infektionen

Panknin¹

2015

ProCare

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“…When patients developed infections caused by resistant microorganisms, this rate can rise up to 70% (3,(10)(11) . Brazilian studies reports similar rates, reaching 50% when associated with infections by resistant microorganisms (8)(9) .…”

Section: Introductionmentioning

confidence: 99%

Bacterial Resistance and Mortality in an Intensive Care Unit

Oliveira

Silva

Diaz

et al. 2010

Rev. Latino-Am. Enfermagem

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The goal was to identify risk factors for healthcare-associated infections by resistant Resistencia bacteriana y mortalidad en un Centro de Terapia IntensivaSe objetivó identificar factores de riesgo para el desarrollo de infecciones relacionadas al cuidar en salud, por microorganismos resistentes, y también investigar su relación con la mortalidad de los pacientes en un centro de terapia intensiva. Se trata de un estudio epidemiológico prospectivo realizado entre 2005 y 2008, envolviendo 2.300 pacientes. Se utilizó la estadística descriptiva y el análisis de regresión logístico bivariado y multivariado. En el análisis bivariado, la infección por microorganismos resistentes estuvo significativamente asociada a pacientes con infección comunitaria (p=0,03; OR=1,79) y a la colonización por microorganismo resistente (p<0,01; OR=14,22). En el análisis multivariado la severidad clínica C (p=0,03; OR=0,25) y la colonización por microorganismo resistente (p<0,01; OR=21,73) fueron significativas. En relación a las muertes, se observó como factor de riesgo: el tipo de paciente, la severidad clínica, y el uso de ventilación mecánica. La constatación de la relación entre los microorganismos resistentes y la muerte, coloca en evidencia la necesidad de monitorizar la adhesión a las medidas de control de la infección con el objetivo de mejorar la calidad de la asistencia y, sobre todo, la sobrevivencia de los pacientes críticos.

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Nosocomial lung infections in adult intensive care units

Cited by 21 publications

References 108 publications

Efflux pump genes and antimicrobial resistance of Pseudomonas aeruginosa strains isolated from lower respiratory tract infections acquired in an intensive care unit

Efflux pump genes and antimicrobial resistance of Pseudomonas aeruginosa strains isolated from lower respiratory tract infections acquired in an intensive care unit

Nosokomiale Infektionen

Bacterial Resistance and Mortality in an Intensive Care Unit

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