Nosocomial infections caused by Crimean–Congo haemorrhagic fever virus

Tsergouli, Katerina; Κarampatakis, Theodoros; Haidich, Anna‐Bettina; Metallidis, Symeon; Papa, Anna

doi:10.1016/j.jhin.2019.12.001

Cited by 45 publications

(42 citation statements)

References 76 publications

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“…The diseases caused by the tick-borne virus are numerous and severe. In Africa, Asia, and Europe, 158 cases of CCHFV (Crimean-Congo hemorrhagic fever virus) infection were published from 1953 to 2016, with an overall case fatality rate of 32.4% [ 3 ]. SFTS (Severe fever with thrombocytopenia syndrome), with a 5.3% national average mortality rate, was reported in 23 provinces of China, with increased numbers yearly from 2010 to 2016 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Virome analysis of ticks in a forest region of Liaoning, China: characterization of a novel hepe-like virus sequence

Zhang

Yang

et al. 2021

Virol J

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Background Ticks (class Arachnida, subclass Acari) are vectors of transmitting a broad range of pathogenic microorganisms, protozoa, and viruses affecting humans and animals. Liaoning Province is rich in forests where different animals and, abundant Haemaphysalis longicornis ticks exist. Methods Using viral metagenomics, we analyzed the virome in 300 Haemaphysalis longicornis ticks collected from June to August 2015 in the forested region of Liaoning Province, China. Results From the 300 ticks, 1,218,388 high-quality reads were generated, of which 5643 (0.463%) reads showed significant sequence identity to known viruses. Sequence and phylogenetic analysis revealed that viral sequences showing a close relationship with Dabieshan tick virus, Aleutian mink disease virus, adeno-associated virus, Gokushovirus, avian gyrovirus 2 were present in the virome of these ticks. However, the significance of these viruses to human and animal health requires further investigation. Notably, an hepe-like virus, named tick-borne hepe-like virus sequence, was obtained and was highly prevalent in these ticks with a rate of 50%. Nevertheless, one constraint of our study was the limited geographical distribution of the sampled ticks. Conclusion Our study offers an overview of the virome in ticks from a forest region of Liaoning Province and provides further awareness of the viral diversity of ticks.

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Section: Introductionmentioning

confidence: 99%

Virome analysis of ticks in a forest region of Liaoning, China: characterization of a novel hepe-like virus sequence

Zhang

Yang

et al. 2021

Virol J

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“…High risk occupations for CCHFV infection include veterinarians, farmers, and abattoir workers in endemic areas that are in close proximity to livestock (50)(51)(52). Human-tohuman transmission can occur following close contact with infected individuals, posing considerable risk for nosocomial outbreaks (53)(54)(55).…”

Section: Crimean-congo Haemorrhagic Fevermentioning

confidence: 99%

The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever

et al. 2021

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Outbreaks that occur as a result of zoonotic spillover from an animal reservoir continue to highlight the importance of studying the disease interface between species. One Health approaches recognise the interdependence of human and animal health and the environmental interplay. Improving the understanding and prevention of zoonotic diseases may be achieved through greater consideration of these relationships, potentially leading to better health outcomes across species. In this review, special emphasis is given on the emerging and outbreak pathogen Crimean-Congo Haemorrhagic Fever virus (CCHFV) that can cause severe disease in humans. We discuss the efforts undertaken to better understand CCHF and the importance of integrating veterinary and human research for this pathogen. Furthermore, we consider the use of closely related nairoviruses to model human disease caused by CCHFV. We discuss intervention approaches with potential application for managing CCHFV spread, and how this concept may benefit both animal and human health.

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“…Health-care workers are an important risk group for nosocomial infections of CCHF stressing the need of proper well-equipped isolation wards with provision of personal protective equipment to attending health care staff. CCHF is recognised as an important cause of nosocomial infections with a high a mortality rate (CFR) requiring a standard contact, barrier precautions and airborne preventive measures adoption during management of patients with CCHF, obligating the need for guidelines and health education of healthcare workers to reduce the healthcare-associated CCHFV exposure (Tsergouli et al, 2020).Strict infection prevention and control measures in the hospital environment with adoption of biosafety measure required for control of CCHF infections.…”

Section: (5%)mentioning

confidence: 99%

‘Characterisation of suspected Crimean-Congo Haemorrhagic Fever (CCHF) cases in a public sector hospital Islamabad’

Noreen¹,

Saima

Irum

et al. 2020

Global Security: Health, Science and Policy

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Pakistan has been experiencing a continuous rise in the incidence of Crimean Congo Haemorrhagic Fever (CCHF). Sporadic cases of CCHF are reported from rural areas of Punjab, Azad Jammu Kashmir and Khyber Pakhtunkhwa and neighbouring Afghanistan where cattle herding is common. The objective of this paper was to describe the epidemiology of CCHF. A descriptive study was carried out in the CCHF isolation ward in Islamabad in a tertiary care hospital from February to November 2018. Using a standardised case definition, all patients admitted in the isolation ward with clinical evidence of CCHF were included in the study. After taking the informed consent, data were collected on demographic factors, history of animal contact, tick-bite history, co-morbidity, laboratory results and treatment outcome. Data were analysed as per time, place and person. During the study period, 40 suspected CCHF patients were admitted in the isolation ward, 32 (80%) males were affected. Mean age of the cases was 33.5 years (range 13-70 years). Most affected 17 (42.5%) age group was 20-29 years. Animal contact history was found in Thirty-seven (92.5%) of cases and 28 (70%) with tick bites. Most of the cases, 26 (65%), were reported from July to August. Forty patients in this study were tested by Real Time Polymerase Chain Reaction (PCR), 20 (50%) were positive, out of which 6(30%) expired. Majority of the positive patients were animal handlers by occupation (37.5%). Proper personal protective equipment was available. The reference laboratory facility was not available for immediate investigations was sent to National Institute of Health for confirmation. The overall results show the important risk factors for CCHF a history of tick bites, high-risk occupations and having contact with livestock. Public health measures should focus on preventing tick bites, increasing awareness of CCHF signs and symptoms, timely investigation, and treatment to reduce mortality. Our analyses recommend the government to set up isolation units in all major hospitals, and proper surveillance system.

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Nosocomial infections caused by Crimean–Congo haemorrhagic fever virus

Cited by 45 publications

References 76 publications

Virome analysis of ticks in a forest region of Liaoning, China: characterization of a novel hepe-like virus sequence

Virome analysis of ticks in a forest region of Liaoning, China: characterization of a novel hepe-like virus sequence

The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever

‘Characterisation of suspected Crimean-Congo Haemorrhagic Fever (CCHF) cases in a public sector hospital Islamabad’

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