Nosocomial H1N1 infection during 2010–2011 pandemic: a retrospective cohort study from a tertiary referral hospital

Veenith, Tonny; Sanfilippo, Filippo; Ercole, Ari; Carter, E.; Goldman, Nina; Bradley, Patrick; Gunning, K.; Burnstein, Rowan

doi:10.1016/j.jhin.2012.04.010

Cited by 10 publications

(9 citation statements)

References 9 publications

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“…Our estimate of the extent of nosocomial transmission based on the classical method (15%) was similar to previous estimates in UK settings, which defined nosocomial infection based on presentation of symptoms 3‐4 days after hospital admission and gave estimates of nosocomial infection of 2%‐12% . Although our estimate derived using genetic clustering produced a similar value (16%), there was a lack of concordance between the two methods.…”

Section: Discussionsupporting

confidence: 78%

Nosocomial transmission of influenza: A retrospective cross‐sectional study using next generation sequencing at a hospital in England (2012‐2014)

Blackburn¹,

Frampton²,

Smith³

et al. 2019

Influenza Resp Viruses

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BackgroundThe extent of transmission of influenza in hospital settings is poorly understood. Next generation sequencing may improve this by providing information on the genetic relatedness of viral strains.ObjectivesWe aimed to apply next generation sequencing to describe transmission in hospital and compare with methods based on routinely‐collected data.MethodsAll influenza samples taken through routine care from patients at University College London Hospitals NHS Foundation Trust (September 2012 to March 2014) were included. We conducted Illumina sequencing and identified genetic clusters. We compared nosocomial transmission estimates defined using classical methods (based on time from admission to sample) and genetic clustering. We identified pairs of cases with space‐time links and assessed genetic relatedness.ResultsWe sequenced influenza sampled from 214 patients. There were 180 unique genetic strains, 16 (8.8%) of which seeded a new transmission chain. Nosocomial transmission was indicated for 32 (15.0%) cases using the classical definition and 34 (15.8%) based on genetic clustering. Of the 50 patients in a genetic cluster, 11 (22.0%) had known space‐time links with other cases in the same cluster. Genetic distances between pairs of cases with space‐time links were lower than for pairs without spatial links (P < .001).ConclusionsGenetic data confirmed that nosocomial transmission contributes significantly to the hospital burden of influenza and elucidated transmission chains. Prospective next generation sequencing could support outbreak investigations and monitor the impact of infection and control measures.

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Section: Discussionsupporting

confidence: 78%

Nosocomial transmission of influenza: A retrospective cross‐sectional study using next generation sequencing at a hospital in England (2012‐2014)

Blackburn¹,

Frampton²,

Smith³

et al. 2019

Influenza Resp Viruses

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“…1 The study design as well as some details of the surgical hand disinfection procedures do not support this conclusion.…”

Section: Madammentioning

confidence: 94%

“…In addition, pathogens can be dried in organic matter or exist within biofilms, following manual cleaning, which can significantly reduce their susceptibility to disinfection. 1,2 Furthermore, the quality of manual cleaning can vary and has been shown to be suboptimal. The study aimed to mimic worse case conditions rather than lower background microbiological level, i.e.…”

Section: Madammentioning

confidence: 99%

“…1 Campaigns for prevention and treatment of serious influenza A(H1N1) in intensive care units (ICU) have strongly expressed the need to study the viral forms as a cause of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Microbiological laboratories have adapted to the need to establish the causes of serious respiratory failure, especially where it is not possible to establish a bacterial origin.…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

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Virological screening in cases of ALI/ARDS

Peris

Bonizzoli

Zagli

et al. 2012

Journal of Hospital Infection

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“…During the 2009 H1N1 influenza pandemic, health care workers were vulnerable to infection, 15–19 and ill health care workers were suspected as possible sources of nosocomial infections. 20,21 Although discouraging ill health care workers from reporting to work during a pandemic situation when the demand for health care is likely heightened may be difficult, results from this analysis revealed that the practice was implemented most of the time by nearly 8 out of 10 nurses during the pandemic and thus feasible for hospitals to implement. Furthermore, a study from Brazil compared the effectiveness and cost of 2 sick leave policies for health care workers and found that a policy instituting 7 days of sick leave for workers with suspected pandemic influenza was more costly and not more effective in preventing transmission to patients than a policy instituting 2 days of sick leave followed by reassessment every 2 days.…”

Section: Discussionmentioning

confidence: 94%

General influenza infection control policies and practices during the 2009 H1N1 influenza pandemic: A survey of women’s health, obstetric, and neonatal nurses

Ruch‐Ross¹,

Zapata²,

Williams³

et al. 2014

American Journal of Infection Control

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Background An evaluation of infection control practices was conducted following the release of the Centers for Disease Control and Prevention (CDC) guidance regarding the care of pregnant women during the 2009 H1N1 influenza pandemic. This paper describes 9 general hospital practices. Methods A questionnaire was distributed electronically to 12,612 members of the Association of Women’s Health, Obstetric, and Neonatal Nurses (AWHONN). Respondents (N = 2,304) who reported working in obstetric or neonatal settings during the pandemic completed the questionnaire. Results Most (73%) respondents considered the Centers for Disease Control and Prevention’s guidance very useful. Significantly more reported a written hospital policy for each practice during versus before the pandemic. Six of the 9 practices were implemented most of the time by at least 70% of respondents; the practices least often implemented were mandatory vaccination of health care personnel involved (52%) and not involved (34%) in direct patient care and offering vaccination to close contacts of newborns prior to discharge (22%). The most consistent factor associated with implementation was the presence of a written policy supporting the practice at the respondent’s hospital. Conclusion We offer a descriptive account of general hospital infection control policies and practices during the 2009 H1N1 pandemic. Factors associated with reported implementation may be useful to inform planning to protect women and children for future public health emergencies.

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Nosocomial H1N1 infection during 2010–2011 pandemic: a retrospective cohort study from a tertiary referral hospital

Cited by 10 publications

References 9 publications

Nosocomial transmission of influenza: A retrospective cross‐sectional study using next generation sequencing at a hospital in England (2012‐2014)

Nosocomial transmission of influenza: A retrospective cross‐sectional study using next generation sequencing at a hospital in England (2012‐2014)

Virological screening in cases of ALI/ARDS

General influenza infection control policies and practices during the 2009 H1N1 influenza pandemic: A survey of women’s health, obstetric, and neonatal nurses

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