Nosocomial Burkholderia cepacia infection in a tertiary hospital; Five-year surveillance: A retrospective cross-sectional study

Abstract

This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. Abstract Aim: Burkholderia cepacia is an aerobic, Gram-negative and multi-drug resistance bacteria that cannot ferment glucose. Burkholderia cepacia, important opportunistic bacteria in immunosuppressed patients, causes severe pulmonary infections. In this study, we aimed to evaluate Burkholderia cepacia cases detected in last five years. Methods: The study designed as retrospectively. Forty-six cases with B. cepacia in the tertiary hospital between 2013 and 2018 were included in the study. Age, gender, clinical history of the patient, type of sample taken, and patients' final conditions (alive or dead) and duration of hospitalization were recorded. Results: When the distribution of the samples were examined, it was found that 32.6% (n=15) in the blood culture, 32.6% (n=15) in the urine culture, 17.4% (n=8) in the tracheal aspirate culture and 17.4% (n=8). Patients' final conditions were evaluated as alive or dead. Accordingly, 65.2% (n=30) were alive and 34.8% (n=16) of the patients were dead. When the distribution of the cases according to the clinics were examined, Anesthesia with 19.6% (n=9) was the first place. The average length of stay in hospital was 24.6 ± 25.3 days (minimum-maximum: 3-122 days). Conclusion: Burkholderia cepacia is an important nosocomial opportunistic infection and is often multi drug resistant. For this reason, the disease should be effectively treated otherwise it should not be forgotten that the disease will result in mortality. Öz Amaç: Burkholderia cepacia, glikozu fermente edemeyen aerobik, Gram-negatif ve çok ilaca dirençli bir bakteridir. İmmunsüprese hastalarda önemli bir fırsatçı bakteri olan Burkholderia cepacia, ciddi pulmoner enfeksiyonlara neden olur. Bu çalışmada, son beş yılda tespit edilen Burkholderia cepacia vakalarını değerlendirmeyi amaçladık. Yöntemler: Çalışma retrospektif olarak planlandı. Çalışmaya 2013-2018 yılları arasında üçüncü basamak hastanedeki 46 B. cepacia olgusu dahil edildi. Yaş, cinsiyet, klinik öykü, alınan örnek tipi, hastaların son durumu (yaşıyor veya ölü) ve hastanede yatış süresi kaydedildi. Bulgular: Örneklerin dağılımı incelendiğinde, kan kültüründe %32,6 (n=15), idrar kültüründe %32,6 (n=15), trakeal aspiratta %17.4 (n=8) bulundu. Hastaların son durumları yaşıyor veya ölü olarak değerlendirildi. Buna göre, olguların %65,2'sinin (n=30) yaşadığı, %34,8'inin (n=16) ise öldüğü tespit edildi. Olguların kliniklere göre dağılımı incelendiğinde, anestezi %19,6 ile (n=9) ilk sıradaydı. Hastanede kalış süresi ortalama 24,6 ± 25,3 gündü (minimummaksimum: 3-122 gün). Sonuç: Burkholderia cepacia önemli bir nozokomiyal fırsatçı enfeksiyondur ve sıklıkla çok ilaca dirençlidir. Bu sebeple hastalık etkin bir şekilde tedavi e...

Incidence and molecular characterization of multidrug resistance in Gram‐negative bacteria of clinical importance from pharmaceutical wastewaters in South‐western Nigeria

“…The MIC values obtained for imipenem, tobramycin, amikacin, ceftazidime, ciprofloxacin, piperacillin, and piperacillin/tazobactam ranging from 0.5 to 128 (µg/ml) of the environmental isolates of B. cepacia complex from this study were comparable to those obtained from the study by Araque‐Caldeson et al () with MIC values of the same range. Thus, this close similarity would suggest that environmental B. cepacia complex may be a potential source of infection of immune‐compromised or hospitalized patients (Nazik et al, ), at least in Nigeria. Burkholderia spp.…”

“…However, no specific virulence factors have been identified for these species (Sharma et al, 2016). (Nazik et al, 2018), at least in Nigeria. Burkholderia spp.…”