Nosocomial Acinetobacter baumannii infections and changing Antibiotic Resistance

Hakyemez, İsmail Necati; Küçükbayrak, Abdulkadir; Taş, Tekin; Yikilgan, Aslihan Burcu; Akkaya, Akçan; Yaşayacak, Aliye; Akdeniz, Hayrettin

doi:10.12669/pjms.295.3885

Cited by 24 publications

(25 citation statements)

References 18 publications

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“…A. baumannii is an opportunistic pathogen, which affects different groups of people, especially those admitted to the ICU (22). Furthermore, our results found that the trend A. baumannii resistant strains to imipenem was increasing, in confirming this finding, some studies have also reported this phenomenon (9,30,31). In a study of 298 positive cultures of A. baumannii isolated from American soldiers in the Iraq war who were hospitalized at military hospitals between 2003 and 2008, showed that 46 (15%) were resistant to imipenem (32).…”

Section: Discussionsupporting

confidence: 83%

“…World health organization (WHO) declared that Multidrug resistance (MDR) strains of Acinetobacter baumannii are a significant threat worldwide. In total, many studies have shown that the prevalence of MDR strains of A. baumannii has reached an alarming statue all over the world (9), including Iran (10,11). Developing countries such as Iran have serious problems in treating the infections resulted from MDR strains.…”

Section: Introductionmentioning

confidence: 99%

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Increasing Trend of Imipenem-Resistance Among Acinetobacter baumannii Isolated From Hospital Acquired Pneumonia in Northeast of Iran

Khaledi¹,

Elahifar²,

Vazini³

et al. 2017

Avicenna J Clin Microbiol Infect

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Increasing Trend of Imipenem-Resistance Among Acinetobacter baumannii Isolated From Hospital Acquired Pneumonia in Northeast of Iran

Khaledi¹,

Elahifar²,

Vazini³

et al. 2017

Avicenna J Clin Microbiol Infect

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“…High-level resistance to third-generation cephalosporins, quinolones, aminoglycosides, tetracycline and chloramphenicol is widespread in clinical isolates (Shahcheraghi et al, 2011;Lin et al, 2014;Manchanda et al, 2010;Necati Hakyemez et al, 2013). Therefore, treatment regimens often rely on carbapenems and colistin (CLS) (Lin et al, 2014;Sinirtas et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Class 1 integrons in non-clonal multidrug-resistant Acinetobacter baumannii from Iran, description of the new bla IMP-55 allele in In1243

Azizi

Shakibaie

Badmasti

et al. 2016

Journal of Medical Microbiology

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Infections and outbreaks caused by multidrug-resistant Acinetobacter baumannii (MDR-AB) are prevalent and have been reported worldwide over the past 20 or more years. Class 1 integron in MDR-AB plays an important role in the spread of antibiotic resistance in clinical settings. This study has been conducted to evaluate the detection of metallo-b-lactamase, characterization of class 1 integron and determination of clonal relatedness among A. baumannii hospital isolates. Sixty-five clinical isolates of MDR-AB were recovered from two Iranian hospital's intensive care units from February to August 2013. Integrase (intI1) and bla IMP genes were detected in 70.8 % (n=46/65) and 9.23 % (n=6/65) of the isolates using PCR assay, respectively. No other metallo-b-lactamase genes (bla VIM , bla SIM and bla NDM ) were detected. PCR sequencing of integron gene cassette revealed the following arrays: bla OXA10 -aacA4-bla IMP-55 -cmlA5 (as a novel array was designated In1243), aacC1 and aadA1. Analysis of bla IMP gene revealed a new allele designated as bla . Gene transfer experiment by conjugation showed the 36 kb conjugative plasmid harbouring In1243. The clonal assessment by repetitive extragenic palindromic PCR demonstrated a high-degree relatedness among the strains, but strains harbouring In1243 displayed a different repetitive extragenic palindromic PCR profile. In this study, we found that a novel class 1 integron (In1243) that encoded a new bla IMP allele resided on a transferable plasmid in non-clonal strains of MDR-AB.

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“…In the clinical samples, the most commonly encountered opportunistic pathogen is Acinetobacter baumannii. Because of its ability to colonize in the hospital setting and develop resistance, it leads to nosocomial infections that are difficult to treat [27,28]. We detected one case of Acinetobacter baumannii infection in purulent pericardial fluid, which could be of concern in critically ill patients.…”

Section: Discussionmentioning

confidence: 91%

“…increasingly causes nosocomial infections with mortality [26,27]. In the clinical samples, the most commonly encountered opportunistic pathogen is Acinetobacter baumannii.…”

Section: Discussionmentioning

confidence: 99%

Bacterial pericarditis and antimicrobial resistance at the Tehran Heart Center, Iran

Anvari

Kianinejad

Boroumand

et al. 2015

J Infect Dev Ctries

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Introduction: When bacterial pericarditis is suspected, urgent pericardial drainage combined with intravenous antibacterial therapy is mandatory to avert devastating, life-threatening complications. There have been scanty results on antimicrobial susceptibility of common causative microorganisms of bacterial pericarditis; most studies had small sample sizes and were performed decades ago. Methodology: This prospective study surveyed the causative bacteria in infectious pericardial effusions and their antimicrobial susceptibility among 320 consecutive cardiac patients who underwent pericardiocentesis at Tehran Heart Center between 2007 and 2012, using the European Society of Cardiology (ESC)'s criteria. Results: Staphylococcus spp. (S. epidermidis, S. aureus, S. haemolyticus) were the main causative organisms isolated from cultures of pericardial effusion samples. Other causative organisms were Streptococcus spp., Enterococcus faecium, Pseudomonas aeruginosa, and Acinetobacter baumannii. In the cultures studied, 35% methicillin-resistant Staphylococcus epidermidis (MRSE) and 42.9% methicillinresistant Staphylococcus aureus (MRSA) were detected. The most effective antimicrobial agents in S. epidermidis were gentamicin, ciprofloxacin, and cefoxitin. Clindamycin was relatively effective. S. aureus was highly susceptible to clindamycin and erythromycin. In cases of S. haemolyticus infection, clindamycin, erythromycin, cefoxitin, and ciprofloxacin were effective antibiotics. Conclusions: In order to diminish the nascence and extension of antimicrobial-resistant pathogens, logical and optimized antimicrobial usage and monitoring in hospitals are highly recommended. It is incumbent on healthcare systems to determine current local resistance patterns by which to guide empiric antimicrobial therapy for specific infections and microorganism types.

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Nosocomial Acinetobacter baumannii infections and changing Antibiotic Resistance

Cited by 24 publications

References 18 publications

Increasing Trend of Imipenem-Resistance Among Acinetobacter baumannii Isolated From Hospital Acquired Pneumonia in Northeast of Iran

Increasing Trend of Imipenem-Resistance Among Acinetobacter baumannii Isolated From Hospital Acquired Pneumonia in Northeast of Iran

Class 1 integrons in non-clonal multidrug-resistant Acinetobacter baumannii from Iran, description of the new bla IMP-55 allele in In1243

Bacterial pericarditis and antimicrobial resistance at the Tehran Heart Center, Iran

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