Increasing Trend of Imipenem-Resistance Among Acinetobacter baumannii Isolated From Hospital Acquired Pneumonia in Northeast of Iran

Khaledi, Azad; Elahifar, Omid; Vazini, Hossein; Alikhani, Mohammad Yousef; Bahrami, Afsane; Esmaeili, Davoud; Ghazvini, Kiarash

doi:10.5812/ajcmi.45454

Cited by 7 publications

(5 citation statements)

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“…27 The resistance to A. baumannii as one of the most important pathogens acquired from hospitals is increasing and the evaluation of its antimicrobial patterns is so necessary. 28,29 In the present study, antibiotic resistance was observed to different antibiotics. The most resistant to cefotetan, nitrofurantoin, levofloxacin, amikacin, imipenem, piperacillintazobactam, co-trimoxazole, were found in E. coli isolates from urine samples.…”

Section: Discussionsupporting

confidence: 48%

Prevalence of Common Nosocomial Infections and Evaluation of Antibiotic Resistance Patterns in Patients with Secondary Infections in Hamadan, Iran

Nouri¹,

Karami²,

Zarei³

et al. 2020

IDR

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Introduction: The prevalence of nosocomial infections in patients hospitalized to three hospitals of Shahid Beheshti, Farshchian, and Be' saat in Hamadan was investigated for 2 years (2018 to 2020). Materials and Methods: The samples were cultured and characterized using morphological and diagnostic biochemical tests. The analysis of the frequency of the isolates and their antibiotic resistance were calculated using SPSS (version 22) at a significant level of P-value < 0.05. Results: Bacterial isolates were collected from the 1194 clinical specimens, of which 1394 were isolated from urine, 16 from CSF, and 588 from tracheal aspiration. Also, 654 (54.8%) isolates were obtained from females and 540 (45.2%) from males with the age range 15-73 years (P> 0.05). The results showed that 22.1% were gram-positive and 77.9% were gramnegative. In our study, the frequency of Klebsiella pneumoniae bacteria was higher than in some studies, and this indicates the genetic changes and resistance of this bacterium to many antibiotics. Conclusion: To prevent further spread of resistance, increase the effectiveness of antibiotics and prevent multidrug resistance, it is essential to establish a precise schedule for the use of antibiotics and assess the resistance pattern periodically in each region based on the antibiotic resistance pattern.

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Section: Discussionsupporting

confidence: 48%

Prevalence of Common Nosocomial Infections and Evaluation of Antibiotic Resistance Patterns in Patients with Secondary Infections in Hamadan, Iran

Nouri¹,

Karami²,

Zarei³

et al. 2020

IDR

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“…Patients who were hospitalized with signs and symptoms of infection were involved in the study. The demographic data of patients concerning gender, signs, and symptoms were collected (Dhabaan et al, 2011, Lusignani et al, 2017 The statistical analysis was performed using the SPSS Statistics [version22]. The data were presented as percentages; Chi-square was used to calculate significance for frequencies.…”

Section: Methodsmentioning

confidence: 99%

“…Acinetobacter baumannii has emerged as a prominent cause of nosocomial infections, particularly in intensive care units (ICUs), initiating a variety of infections including respiratory tract infection, septicemia, urinary tract infections and wound infections (Al-Dabaibah et al, 2012, Aljindan et al, 2015 The nosocomial infection is the infection that happens after 48 hours of admission of patients in the hospital, shortly after hospitalization, and on entrance moment the patient did not have such an infection (Amini et al, 2012, Khaledi et al, 2017. Hospital-acquired infections can cause increased patient morbidity and mortality, affect the achievement of initial illness treatment, prolonged hospital stay which then causes additional budgets for the health care system (Ozdemir et al, 2011, Armin et al, 2015.…”

Section: Introductionmentioning

confidence: 99%

A Prevalence of infections with antibiotic-resistant Acinetobacter baumannii in different clinical samples from hospitals in Erbil

2020

ZJPAS

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is one of the important pathogen causing nosocomial infections. This pathogen is Acinetobacter baumannii resistant-Drug rbidity. The aim of the study becoming resistant to a large group of antimicrobial agents, leading to a high rate of mortality and mo isolates from different clinical samples and analyze its antibiotic obacter baumannii Acinet the prevalence of to determine was. During the period of study from November 2016 to December 2017, different rofiles, and pathogenic perspective susceptibility p swab, burn, sputum and blood) obtained from patients hospitalized in Par private clinical specimens including (urine, wound A. hospital and Rizgari teaching hospital in Erbil city. Conventional microbiological methods were used for identification of performed by the method commended by the Clinical Laboratory and Standards. Antibiotic susceptibility testing was baumannii nosocomial infection was increasing especially in patients with risk factors, the current study baumannii A. Institute (CLSI). baumannii A. countered 20 (51.3%) followed by others. The prevalence of showed that sputum isolates are the most frequently en 3 25 1 1 14 12 3 T ce, most of the isolates even non susceptible to carbapenems with the revealed that there was an increase in antimicrobial resistan drug-exception of colistin that had an effective rule in comparison with the others. The study showed that the incidence of multi A. nce in A. baumannii to carbapenems was rising. Most isolates of was high and the rate of resista A. baumannii resistance resistance against antibiotics.-were multi baumannii

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“…The center for disease control and prevention have been proclaimed that P. aeruginosa infection is the fourth most common isolated nosocomial pathogen in US which accounts about 10% of all hospital-acquired infections [ 6 ]. Reports from Iran also confirm that it is among the most common causes of nosocomial infections [ 7 ]. Not only in the developed countries, has the prevalence of P. aeruginosa also risen in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of meropenem-resistant Pseudomonas Aeruginosa in Ethiopia: a systematic review and meta‑analysis

Gobezie,

Hassen,

Tesfaye

et al. 2024

Antimicrob Resist Infect Control

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Introduction Antimicrobial resistance (AMR) is a pressing global health concern, particularly pronounced in low-resource settings. In Ethiopia, the escalating prevalence of carbapenem-resistant Pseudomonas aeruginosa (P. aeruginosa) poses a substantial threat to public health. Methods A comprehensive search of databases, including PubMed, Scopus, Embase, Hinari, and Google Scholar, identified relevant studies. Inclusion criteria encompassed observational studies reporting the prevalence of meropenem-resistant P. aeruginosa in Ethiopia. Quality assessment utilized JBI checklists. A random-effects meta-analysis pooled data on study characteristics and prevalence estimates, with subsequent subgroup and sensitivity analyses. Publication bias was assessed graphically and statistically. Results Out of 433 studies, nineteen, comprising a total sample of 11,131, met inclusion criteria. The pooled prevalence of meropenem-resistant P. aeruginosa was 15% (95% CI: 10–21%). Significant heterogeneity (I2 = 83.6%) was observed, with the number of P. aeruginosa isolates identified as the primary source of heterogeneity (p = 0.127). Subgroup analysis by infection source revealed a higher prevalence in hospital-acquired infections (28%, 95% CI: 10, 46) compared to community settings (6%, 95% CI: 2, 11). Geographic based subgroup analysis indicated the highest prevalence in the Amhara region (23%, 95% CI: 8, 38), followed by Addis Ababa (21%, 95% CI: 11, 32), and lower prevalence in the Oromia region (7%, 95% CI: 4, 19). Wound samples exhibited the highest resistance (25%, 95% CI: 25, 78), while sputum samples showed the lowest prevalence. Publication bias, identified through funnel plot examination and Egger’s regression test (p < 0.001), execution of trim and fill analysis resulted in an adjusted pooled prevalence of (3.7%, 95% CI: 2.3, 9.6). Conclusion The noteworthy prevalence of meropenem resistance among P. aeruginosa isolates in Ethiopia, particularly in healthcare settings, underscores the urgency of implementing strict infection control practices and antibiotic stewardship. Further research is imperative to address and mitigate the challenges posed by antimicrobial resistance in the country.

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Increasing Trend of Imipenem-Resistance Among Acinetobacter baumannii Isolated From Hospital Acquired Pneumonia in Northeast of Iran

Abstract: Background: Nosocomial infections due to high mortality and economic cost are one of the most important challenges that hospitals face with it. Reports show that hospital acquired pneumonia (HAP) is the second most common nosocomial infection in some countries such as the United States.

Cited by 7 publications

References 26 publications

<p>Prevalence of Common Nosocomial Infections and Evaluation of Antibiotic Resistance Patterns in Patients with Secondary Infections in Hamadan, Iran</p>

<p>Prevalence of Common Nosocomial Infections and Evaluation of Antibiotic Resistance Patterns in Patients with Secondary Infections in Hamadan, Iran</p>

A Prevalence of infections with antibiotic-resistant Acinetobacter baumannii in different clinical samples from hospitals in Erbil

Prevalence of meropenem-resistant Pseudomonas Aeruginosa in Ethiopia: a systematic review and meta‑analysis

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