Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization

Optimized Green Nanoemulsions to Remove Pharmaceutical Enoxacin from Contaminated Bulk Aqueous Solution

“… 24 Solubilizing properties/emulsification behavior of transcutol-HP (THP) (HLB = 14.5) for C90-oil was facilitated when a blend of lecithin (HLB = 4.2) and THP was used as a combined mix after dispersion/titration with aqueous phase working in tandem. 48 NMP and Tween 80 worked together efficiently for rapid emulsification of ENE1–ENE5 in the bulk aqueous ENO solution (gave o/w nanoemulsion) with clear transparency. Moreover, biocompatible and lipophilic lecithin served as surfactant for stabilized nanoemulsion before dispersion.…”

“…Other ratios (2:1 and 3:1) could not work to get a stable nanoemulsion and dropped from further studies (data not given) . Solubilizing properties/emulsification behavior of transcutol-HP (THP) (HLB = 14.5) for C90-oil was facilitated when a blend of lecithin (HLB = 4.2) and THP was used as a combined mix after dispersion/titration with aqueous phase working in tandem . NMP and Tween 80 worked together efficiently for rapid emulsification of ENE1–ENE5 in the bulk aqueous ENO solution (gave o/w nanoemulsion) with clear transparency.…”

Optimized Green Nanoemulsions to Remove Pharmaceutical Enoxacin from Contaminated Bulk Aqueous Solution

“… 24 Solubilizing properties/emulsification behavior of transcutol-HP (THP) (HLB = 14.5) for C90-oil was facilitated when a blend of lecithin (HLB = 4.2) and THP was used as a combined mix after dispersion/titration with aqueous phase working in tandem. 48 NMP and Tween 80 worked together efficiently for rapid emulsification of ENE1–ENE5 in the bulk aqueous ENO solution (gave o/w nanoemulsion) with clear transparency. Moreover, biocompatible and lipophilic lecithin served as surfactant for stabilized nanoemulsion before dispersion.…”

“…Other ratios (2:1 and 3:1) could not work to get a stable nanoemulsion and dropped from further studies (data not given) . Solubilizing properties/emulsification behavior of transcutol-HP (THP) (HLB = 14.5) for C90-oil was facilitated when a blend of lecithin (HLB = 4.2) and THP was used as a combined mix after dispersion/titration with aqueous phase working in tandem . NMP and Tween 80 worked together efficiently for rapid emulsification of ENE1–ENE5 in the bulk aqueous ENO solution (gave o/w nanoemulsion) with clear transparency.…”

Brain-Targeted Intranasal Delivery of Zotepine Microemulsion: Pharmacokinetics and Pharmacodynamics

“…These mechanisms imply that a portion of ZTP reached the brain following the above two pathways bestow intranasal dosing. Because of its smaller globule size, the ZTP-ME formulation has a high DTE percent and DTP percent, indicating that the medication is immediately transferred to the brain via the transcellular route following an intranasal dosage [ 27 ].…”

Surface Modification of Curcumin Microemulsions by Coupling of KLVFF Peptide: A Prototype for Targeted Bifunctional Microemulsions

“…The solubility of curcumin in various oils and co-surfactants was analyzed to screen the components for microemulsions. Selecting the best oil phase was required for the maximum solubility potential for the drug to cover a larger ME region in the ternary plots and obtain a stable ME [ 17 , 52 ]. Solubility data for the curcumin in oil, surfactant, and co-surfactant are shown in Figure 4 .…”

“…The colloidal stability of MEs with a slightly negative charge was previously discussed [ 15 ]. Several reports have shown that MEs containing slightly negative values of the zeta potential have shown a good colloidal stability [ 17 , 62 , 63 , 64 , 65 ]. However, only obtaining the zeta potential value is not enough to predict the stability of formulations, and a stability study should be performed to confirm the stability of the formulation in our future study.…”

Optimized Green Nanoemulsions to Remove Pharmaceutical Enoxacin from Contaminated Bulk Aqueous Solution

“… 24 Solubilizing properties/emulsification behavior of transcutol-HP (THP) (HLB = 14.5) for C90-oil was facilitated when a blend of lecithin (HLB = 4.2) and THP was used as a combined mix after dispersion/titration with aqueous phase working in tandem. 48 NMP and Tween 80 worked together efficiently for rapid emulsification of ENE1–ENE5 in the bulk aqueous ENO solution (gave o/w nanoemulsion) with clear transparency. Moreover, biocompatible and lipophilic lecithin served as surfactant for stabilized nanoemulsion before dispersion.…”

“…Other ratios (2:1 and 3:1) could not work to get a stable nanoemulsion and dropped from further studies (data not given) . Solubilizing properties/emulsification behavior of transcutol-HP (THP) (HLB = 14.5) for C90-oil was facilitated when a blend of lecithin (HLB = 4.2) and THP was used as a combined mix after dispersion/titration with aqueous phase working in tandem . NMP and Tween 80 worked together efficiently for rapid emulsification of ENE1–ENE5 in the bulk aqueous ENO solution (gave o/w nanoemulsion) with clear transparency.…”

Brain-Targeted Intranasal Delivery of Zotepine Microemulsion: Pharmacokinetics and Pharmacodynamics

“…These mechanisms imply that a portion of ZTP reached the brain following the above two pathways bestow intranasal dosing. Because of its smaller globule size, the ZTP-ME formulation has a high DTE percent and DTP percent, indicating that the medication is immediately transferred to the brain via the transcellular route following an intranasal dosage [ 27 ].…”

Surface Modification of Curcumin Microemulsions by Coupling of KLVFF Peptide: A Prototype for Targeted Bifunctional Microemulsions

“…The solubility of curcumin in various oils and co-surfactants was analyzed to screen the components for microemulsions. Selecting the best oil phase was required for the maximum solubility potential for the drug to cover a larger ME region in the ternary plots and obtain a stable ME [ 17 , 52 ]. Solubility data for the curcumin in oil, surfactant, and co-surfactant are shown in Figure 4 .…”

“…The colloidal stability of MEs with a slightly negative charge was previously discussed [ 15 ]. Several reports have shown that MEs containing slightly negative values of the zeta potential have shown a good colloidal stability [ 17 , 62 , 63 , 64 , 65 ]. However, only obtaining the zeta potential value is not enough to predict the stability of formulations, and a stability study should be performed to confirm the stability of the formulation in our future study.…”

Optimized Green Nanoemulsions to Remove Pharmaceutical Enoxacin from Contaminated Bulk Aqueous Solution

“… 24 Solubilizing properties/emulsification behavior of transcutol-HP (THP) (HLB = 14.5) for C90-oil was facilitated when a blend of lecithin (HLB = 4.2) and THP was used as a combined mix after dispersion/titration with aqueous phase working in tandem. 48 NMP and Tween 80 worked together efficiently for rapid emulsification of ENE1–ENE5 in the bulk aqueous ENO solution (gave o/w nanoemulsion) with clear transparency. Moreover, biocompatible and lipophilic lecithin served as surfactant for stabilized nanoemulsion before dispersion.…”

“…Other ratios (2:1 and 3:1) could not work to get a stable nanoemulsion and dropped from further studies (data not given) . Solubilizing properties/emulsification behavior of transcutol-HP (THP) (HLB = 14.5) for C90-oil was facilitated when a blend of lecithin (HLB = 4.2) and THP was used as a combined mix after dispersion/titration with aqueous phase working in tandem . NMP and Tween 80 worked together efficiently for rapid emulsification of ENE1–ENE5 in the bulk aqueous ENO solution (gave o/w nanoemulsion) with clear transparency.…”

Brain-Targeted Intranasal Delivery of Zotepine Microemulsion: Pharmacokinetics and Pharmacodynamics

“…These mechanisms imply that a portion of ZTP reached the brain following the above two pathways bestow intranasal dosing. Because of its smaller globule size, the ZTP-ME formulation has a high DTE percent and DTP percent, indicating that the medication is immediately transferred to the brain via the transcellular route following an intranasal dosage [ 27 ].…”

Surface Modification of Curcumin Microemulsions by Coupling of KLVFF Peptide: A Prototype for Targeted Bifunctional Microemulsions

“…The solubility of curcumin in various oils and co-surfactants was analyzed to screen the components for microemulsions. Selecting the best oil phase was required for the maximum solubility potential for the drug to cover a larger ME region in the ternary plots and obtain a stable ME [ 17 , 52 ]. Solubility data for the curcumin in oil, surfactant, and co-surfactant are shown in Figure 4 .…”

“…The colloidal stability of MEs with a slightly negative charge was previously discussed [ 15 ]. Several reports have shown that MEs containing slightly negative values of the zeta potential have shown a good colloidal stability [ 17 , 62 , 63 , 64 , 65 ]. However, only obtaining the zeta potential value is not enough to predict the stability of formulations, and a stability study should be performed to confirm the stability of the formulation in our future study.…”