Nose and Skin Carriage of Staphylococcus Aureus in Patients Receiving Penicillin

Moss, Brenda; Squire, J. R.; Topley, Elizabeth; Johnston, C.M.

doi:10.1016/s0140-6736(48)92088-1

Cited by 67 publications

(25 citation statements)

References 11 publications

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“…A significant fraction of the human population is colonized with S. aureus on epithelial surfaces, of which the anterior nares are the most frequent carriage sites (3,11,13,19,20). Longitudinal studies distinguish three carriage patterns among healthy adult individuals (1,6,15,18,21).…”

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confidence: 99%

“…Longitudinal studies distinguish three carriage patterns among healthy adult individuals (1,6,15,18,21). Persistent carriage occurs in about 20% of the adult population, 30% are intermittent carriers, and 50% of individuals are noncarriers (10,13,15,19). Persistent carriers usually carry the same strain for extended periods of time, whereas intermittent carriers tend to host different strains over time (13,18,19).…”

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Dynamics and Determinants of Staphylococcus aureus Carriage in Infancy: the Generation R Study

et al. 2008

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Serial nasal swabs were collected at the ages of 1.5, 6, and 14 months from 443 infants in the Generation R Study. The objective was to study the dynamics and determinants of Staphylococcus aureus nasal carriage in the first year of life. The prevalence of S. aureus carriage decreased in the first year of life, from 52.1% at the age of 1.5 months to 12.9% at 14 months. Persistent carriage, defined as continuous carriage of the same S. aureus strain at the three sampling moments, was rarely detected in early infancy.

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Dynamics and Determinants of Staphylococcus aureus Carriage in Infancy: the Generation R Study

et al. 2008

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“…Over the last 25 years, the incidence of both community-acquired and hospital-acquired S. aureus infections has increased (1,2). It is assumed that most of the infections derive from nasal carriage (3-7) with the nose acting as the primary ecological reservoir of S. aureus in humans (8).…”

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Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus

Melles∗

Gorkink²,

Boelens³

et al. 2004

J. Clin. Invest.

130

154

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The population structure of Staphylococcus aureus carried by healthy humans was determined using a large strain collection of nonclinical origin (n = 829). High-throughput amplified fragment length polymorphism (AFLP) analysis revealed 3 major and 2 minor genetic clusters of S. aureus, which were corroborated by multilocus sequence typing. Major AFLP cluster I comprised 44.4% of the carriage isolates and showed additional heterogeneity whereas major AFLP groups II and III presented 2 homogeneous clusters, including 47.3% of all carriage isolates. Coanalysis of invasive S. aureus strains and epidemic methicillin-resistant S. aureus (MRSA) revealed that all major clusters contained invasive and multiresistant isolates. However, clusters and subclusters with overrepresentation of invasive isolates were also identified. Bacteremia in elderly adults, for instance, was caused by a IVa cluster-derived strain significantly more often than by strains from other AFLP clusters. Furthermore, expansion of multiresistant clones or clones associated with skin disease (impetigo) was detected, which suggests that epidemic potential is present in pathogenic strains of S. aureus. In addition, the virulence gene encoding Panton-Valentine leukocidin was significantly enriched in S. aureus strains causing abscesses and arthritis in comparison with the carriage group. We provide evidence that essentially any S. aureus genotype carried by humans can transform into a life-threatening human pathogen but that certain clones are more virulent than others.

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“…Hallman 34 (1937); McFarlan 47 (1938); Gillepsie e col. 32 (1939) e Rountree e Barbour 64 (1951) verificaram, em pessoas assintomáticas, índices de portadores nasais de 30-50%, e Moss e col. 51 (1948) observaram proporções de 32% a 76% em fossas nasais e vestíbulo nasal, respectivamente.…”

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Staphylococcus aureus enterotoxigênico no vestíbulo nasal de manipuladores de alimentos em cozinhas de hospitais do município de João Pessoa, PB, Brasil

Castro

Iaria

1984

Rev. Saúde Pública

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RESUMO: Realizou-se a pesquisa de S. aureus em material de vestíbulo nasal de 78 manipuladores de alimentos que trabalhavam nas cozinhas de 8 hospitais. As cepas isoladas, após a sua identificação bioquímica, foram submetidas a provas de fagotipagem e à verificação da capacidade produtora de enterotoxina estafilocócica. Na produção de enterotoxina utilizou-se um método de cultura em saco de celofane. Nas provas de fagotipagem foram empregados os fagos do Conjunto Básico Internacional e mais sete experimentais (86, 88, 89, 90,92, D11 e HK2) e dois extras (187 e 42D). Dos manipuladores examinados, 33 (42,3%) revelaram-se portadores nasais de S. aureus, sendo que de 5 (6,4%) foram isoladas cepas produtoras de enterotoxina estafilocócica. De dois isolaram-se cepas produtoras de enterotoxina do tipo B e dos outros três indivíduos, cepas produtoras de enterotoxinas dos tipos C, AE e ABE, respectivamente. Das 59 submetidas à fagotipagem, 54 (91,5%) revelaram-se fagotipáveis. Houve predominância de cepas lisadas por fagos do grupo III, seguido pelos NC (Não Classificados), em ambos os casos, isoladamente ou em associação.

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Nose and Skin Carriage of Staphylococcus Aureus in Patients Receiving Penicillin

Cited by 67 publications

References 11 publications

Dynamics and Determinants of Staphylococcus aureus Carriage in Infancy: the Generation R Study

Dynamics and Determinants of Staphylococcus aureus Carriage in Infancy: the Generation R Study

Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus

Staphylococcus aureus enterotoxigênico no vestíbulo nasal de manipuladores de alimentos em cozinhas de hospitais do município de João Pessoa, PB, Brasil

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