Nortriptyline hydrochloride skin absorption: Development of a transdermal patch

Melero, Ana; Garrigues, Teresa María; Almudever, Patricia; Villodre, A. Martı ́n; Lehr, Claus‐Michael; Schäfer, U.

doi:10.1016/j.ejpb.2007.11.012

Cited by 37 publications

(25 citation statements)

References 29 publications

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“…In addition, the results obtained in swelling, WVP and DSC studies show differences between ionic polymer film and HPMC film. The critical parameter seems to be the buccal film structure (Melero et al, 2008), influencing in the adhesive contact and the drug permeation.…”

Section: Study Of the Drug Permeationmentioning

confidence: 99%

Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia

et al. 2014

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Tricyclic antidepressants, as doxepin hydrochloride (DH), may have analgesic local effect due to its biochemical mechanism of action. Delivery of DH directly to the oral cavity could be an interesting alternative for toothache due to its analgesic local effect. One problem associated with the mucosal administration routes is the short residence time of the dosage form on the mucosal membranes. In this sense, we have developed new doxepin mucoadhesive films able of reducing pain and increasing the effectiveness of treatment. For this purpose, we tested three different polymers: chitosan, sodium hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (SCMC) in film elaboration. The results obtained show that all films are hydrophilic matrices that absorb water when placed in an aqueous media. All the films hydrated very quickly, reaching high percentage of swelling after just few minutes (5 min for SCMC, 2 min for HPMC and 30 min for chitosan). Moreover, the SCMC and HPMC films were dissolved whereas chitosan was not dissolved. Dissolution also leads to viscous liquids with a higher retention time over mucosal surfaces what may lead to adhesive interactions. In vitro permeation studies showed that for all the formulations studied, SCMC (19.91%), HPMC (69.5%) and chitosan (24.17%), the percentage of drug permeated increased compared to the drug solution (8.26%). Specifically the HPMC film presents greater amounts of doxepin permeated (49.27 ± 4.47 mg/cm 2 ).

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Section: Study Of the Drug Permeationmentioning

confidence: 99%

Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia

et al. 2014

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“…The absorbance frequency shift, area and height of C-H symmetric absorbance peaks were analysed and the results are given in Figure 6a,b. Chemical enhancers are commonly incorporated in transdermal drug delivery systems in order to improve the diffusion kinetics of the drugs administered [47]. Terpenes act to alter the lipid or protein structures in the stratum corneum by modifying the intercellular packing, disrupting the order of lipids, and/or increasing drug diffusivity into the tissue [20,21,48].…”

Section: Code Hardness (N) Elasticity (Mj) Cohesiveness Adhesiveness mentioning

confidence: 99%

Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

et al. 2014

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Abstract:The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features of the MTC loaded transdermal films. Terpinolene provided the highest drug release among the different terpenes (nerolidol, eucalyptol, dl-limonene, or terpinolene) assessed as enhancer. Attenuated Total Reflectance Infrared (ATR-FTIR) spectroscopy analysis performed to evaluate the effect of the transdermal films on skin barrier confirmed enhancer induced lipid bilayer disruption in stratum corneum, indicating its permeation enhancement effect.

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“…Clinical studies have demonstrated that controlled release drug treatment is clinically more valuable to commence and preserve the anticholinergic properties compared to instantaneous release or conventional therapy [1][2][3][4][5][6][7]. Therefore, there is a need to prepare formulations for the controlled and safe-release of drugs which may be done by using clay based materials.…”

Section: Introductionmentioning

confidence: 99%

Montmorillonite/Poly (L-Lactide) microcomposite spheres as reservoirs of antidepressant drugs and their controlled release property

Rajkumar

Kevadiya

Bajaj

2015

Asian Journal of Pharmaceutical Sciences

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This work evaluates intercalation of Nortriptyline (NT) and Venlafaxine (VFX) in interlayer gallery of Na + -MMT (Montmorillonite), which was further compounded with Poly (L-Lactide) (PLLA) to form microcomposite spheres (MPs) for oral controlled drug delivery. The XRD patterns, thermal and spectroscopic analyses indicated intercalation of drugs into the MMT interlayer that was stabilized by electrostatic interaction. No significant changes in structural and functional properties of drugs were found in the MMT layers. In vitro drug release studies showed controlled release pattern.

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Nortriptyline hydrochloride skin absorption: Development of a transdermal patch

Cited by 37 publications

References 29 publications

Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia

Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia

Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

Montmorillonite/Poly (L-Lactide) microcomposite spheres as reservoirs of antidepressant drugs and their controlled release property

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