Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

Aktar, Betül; Erdal, Meryem Sedef; Sağırlı, Olcay; Güngör, Sevgi; Özsoy, Yıldız

doi:10.3390/polym6051350

Cited by 23 publications

(9 citation statements)

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“…The measurement of bioadhesion strength is commonly performed by the use of a texture analyzer which measures the detachment force in tensile mode. This technique has been widely employed in measuring the in vitro bioadhesive strength of polymer-based films (16,17,19,22). We used dorsal skin of pig in vitro as the substrate for testing adhesive properties of the formulated films and a quantitative evaluation was made by measuring the work of adhesion.…”

Section: Resultsmentioning

confidence: 99%

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Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

2014

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Abstract. Matrix type transdermal films of donepezil (DNP) as an alternative delivery approach was designed to improve patient compliance to Alzheimer disease treatment. Sodium alginate, a natural polysaccharide, was used as matrix-forming agent in the optimization of transdermal films. Propylene glycol and dl-limonene was added into films as a plasticizer and permeation enhancer, respectively. As well as mechanical strength and bioadhesiveness of optimized transdermal films of DNP, the impact of dl-limonene concentration in films on DNP in vitro permeation across pig skin was assessed. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) measurements were carried out to examine the effects of enhancer on in vitro conformational order of the stratum corneum intercellular lipids following permeation study. Results showed that transdermal formulations of DNP were suitable due to both mechanical and bioadhesive features of the films. In vitro skin permeation study indicated that dl-limonene at a concentration of 3% was optimum with high drug flux. ATR-FTIR results confirmed a more fluidized stratum corneum lipid state in the presence of dl-limonene, indicating its permeation enhancement effect. Regarding to achieve therapeutic levels of DNP, it seems to be feasible deliver DNP with transdermal films for the management of Alzheimer disease.

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Section: Resultsmentioning

confidence: 99%

“…Sodium alginate is generally regarded as a nontoxic and nonirritant material and is GRAS listed (15). Previously, the transdermal films in which sodium alginate was used as matrix polymer have shown good characteristics in terms of mechanical strength, flexibility, and bioadhesiveness of the films (16,17).…”

Section: Introductionmentioning

confidence: 99%

Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

2014

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“…Several types of polymeric materials have been studied over the last decade, in order to form bioadhesive films for controlled release of drugs through the skin [1,2]. These devices can improve the bioavailability of drugs that suffer presystemic hepatic metabolism when administered orally and consequently optimize the pharmacotherapy, since they can maintain the correct concentration in the plasma, thus not requiring multiple daily administrations [3].…”

Section: Introductionmentioning

confidence: 99%

Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films

Oshiro

Carvalho

Soares

et al. 2015

International Journal of Polymer Science

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The hydrolysis and condensation reactions involved in synthesis of ureasil-polyether films influence the film formation time and the number of chemical groups able to form hydrogen bonds, responsible for the bioadhesion, with the biological substrate. The objective of this work was to study the influence of the use of an acid catalyst (hydrochloric acid) and a basic catalyst (ammonium fluoride) in the hydrolysis and condensation reactions on the time formation and bioadhesion of ureasil-polyether films. The toxicity of the films was evaluated. The MTT assay has shown cell viability of human skin keratinocytes higher than 70% of all analyzed materials suggesting low cytotoxicity. The bioadhesion of the films is strongly dependent on the viscosity and hydrophilic/hydrophobic balance of the polyether chains used to synthetize the hybrid molecules. The use of acid catalyst promotes the formation of less viscous films with higher bioadhesion. The hybrids formed by more hydrophilic PEO chains are more bioadherent, since they can interact more efficiently with the water present in the stratum corneum increasing the bioadhesion. Due to their low toxicity and high bioadhesion, the ureasil-PEO films obtained by using HCl as catalyst agent are good candidates for application to the skin as bioadhesive films.

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“…The films were developed and evaluated for different parameters like drug content, folding endurance, thickness, weight variation, surface pH, moisture uptake, in vitro drug release study and ex-vivo permeation study [16,17,18,19,20]. Physical Appearance: All the films were visually observed for any defect.…”

Section: Evaluation Of Polymer-based Filmsmentioning

confidence: 99%

Non-invasive drug delivery system for the delivery of protein/peptide using neem gum and its derivatives

2020

Biointerface Res Appl Chem

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The present investigation is continuation of author’s previous work. In previous work, the author was prepared acrylamide grafted copolymer of neem gum and carboxymethylatedneem gum derivatives. Neem gum polysaccharide (NGP) and its derivatives viz. acrylamide grafted neem gum (NGP-g-Am) and carboxymethylated neem gum (CMNGP) were explored as film forming agent for transdermal delivery of protein/peptide drug (albumin). It was observed that films were not prepared at all the concentrations of NGP with a given concentration range. Studies show that film cannot be prepared using CMNGP even at ahigher concentration of polymer (2 % w/v solution). So only acrylamide grafted neem gum based film were prepared and evaluated. Transdermal films were prepared by using solvent casting method. The developed films were evaluated for various parameters such as drug content, folding endurance, thickness, weight variation, surface pH, moisture uptake, in vitro drug release study and ex-vivo permeation study. The films showed more than 300 folding endurance which demonstrated the good mechanical strength of film. It was also observed that after permeation studies small cracks were also formed in the films. Fabricated films were able to deliver drug upto 7 h. Drug release study and drug permeation studies showed that formulations followed zero order and KorsmeyerPepass model of kinetics. It can be concluded from the findings of the results that acrylamide graft copolymers of neem gum were able to deliver protein/peptide drugs through transdermal route.

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Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

Cited by 23 publications

References 50 publications

Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films

Non-invasive drug delivery system for the delivery of protein/peptide using neem gum and its derivatives

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