Northern pig‐tailed macaques (<i>Macaca leonina</i>) maintain superior CD4<sup>+</sup> T‐cell homeostasis during SIVmac239 infection

Zhang, Mingxu; Zheng, Hong-Yi; Jen, Jin; Song, Jiahao; Chen, Min; Xiao, Yu; Lian, Xiaodong; Song, Tian-Zhang; Tian, Ren‐Rong; Pang, Wei; Zheng, Yong‐Tang

doi:10.1002/eji.201747284

Cited by 10 publications

(16 citation statements)

References 9 publications

(5 reference statements)

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“…However, in our previous studies, we found that NPMs progressed to AIDS much more slowly than rhesus macaques, and maintained superior CD4+ T cell homeostasis during SIVmac239 infection (32, 33). These results implied great distinctions in physiological and immunologic responses, as well as genetic background between SPMs and NPMs.…”

Section: Introductionmentioning

confidence: 78%

Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina)

Pang

Song

et al. 2018

Front. Immunol.

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The northern pig-tailed macaques (NPMs) lack TRIM5α, an antiviral restriction factor, and instead have TRIM5-CypA. In our previous study, we demonstrated that HIV-1NL4−3 successfully infected NPMs and formed a long-term viral reservoir in vivo. However, the HIV-1-infected NPMs showed relatively high viremia in the first 6 weeks of infection, which declined thereafter suggesting that HIV-1 NL4−3 infection in these animals was only partly permissive. To optimize HIV-1 infection in NPMs therefore, we generated HIV-1NL4−R3A and stHIV-1sv, and infected NPMs with these viruses. HIV-1NL4−R3A and stHIV-1sv can replicate persistently in NPMs during 41 weeks of acute infection stage. Compared to the HIV-1NL4−R3A, stHIV-1sv showed a notably higher level of replication, and the NPMs infected with the latter induced a more robust neutralizing antibody but a weaker cellular immune response. In addition, IFN-I signaling was significantly up-regulated with the viral replication, and was higher in the stHIV-1sv infected macaques. Consequently, the sequences of pro-viral env showed fewer G-A hyper-mutations in stHIV-1sv, suggesting that vif gene of SIV could antagonize the antiviral effects of APOBEC3 proteins in NPMs. Taken together, NPMs infected with HIV-1NL4−R3A and stHIV-1sv show distinct virological and immunological features. Furthermore, interferon-related gene expression might play a role in controlling primary HIV-1NL4−R3A and stHIV-1sv replication in NPMs. This result suggests NPM is a potential HIV/AIDS animal model.

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Section: Introductionmentioning

confidence: 78%

Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina)

Pang

Song

et al. 2018

Front. Immunol.

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“…Non-human primates (NHPs) are crucial animal models for understanding the pathogenesis of HIV infection ( Karlsson et al, 1997 ; Letvin, 1992 ). Simian immunodeficiency virus (SIV) infections in rhesus macaques and northern pig-tailed macaques (NPMs) result in an immunocompromised and AIDS-like disease similar to that seen in HIV patients, as established in our laboratory ( Pang et al, 2017 ; Zhang et al, 2017a , b ). In this study, NPMs with different parasitic loads after infection with SIVmac239 were used to detect immunological and pathological differences to reveal the relationship between viral infection and parasites.…”

Section: Introductionmentioning

confidence: 66%

寄生虫逃避免疫功能不全宿主

et al. 2018

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Parasites can increase infection rates and pathogenicity in immunocompromised human immunodeficiency virus (HIV) patients. However, in vitro studies and epidemiological investigations also suggest that parasites might escape immunocompromised hosts during HIV infection. Due to the lack of direct evidence from animal experiments, the effects of parasitic infections on immunocompromised hosts remain unclear. Here, we detected 14 different parasites in six northern pig-tailed macaques (NPMs) before or at the 50th week of simian immunodeficiency virus (SIV) infection by ELISA. The NPMs all carried parasites before viral injection. At the 50th week after viral injection, the individuals with negative results in parasitic detection (i.e., 08247 and 08287) were characterized as the Parasites Exit (PE) group, with the other individuals (i.e., 09203, 09211, 10205, and 10225) characterized as the Parasites Remain (PR) group. Compared with the PR group, the NPMs in the PE group showed higher viral loads, lower CD4+ T cells counts, and lower CD4/CD8 rates. Additionally, the PE group had higher immune activation and immune exhaustion of both CD4+ and CD8+ T cells. Pathological observation showed greater injury to the liver, cecum, colon, spleen, and mesenteric lymph nodes in the PE group. This study showed more seriously compromised immunity in the PE group, strongly indicating that parasites might exit an immunocompromised host.

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“…A few reports describe kinetic resolution, [14][15][16] dynamic kinetic resolution, 17 or desymmetrization [18][19][20][21] for E-CuAAC. 22 The majority of successful E-CuAAC reactions generate α-C-chiral triazoles, where the new stereocenter is alkyne-derived.…”

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confidence: 99%

Kinetic Resolution of Cyclic Secondary Azides, Using an Enantioselective Copper-Catalyzed Azide–Alkyne Cycloaddition

et al. 2019

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An enantioselective copper-catalyzed azide− alkyne cycloaddition (E-CuAAC) is reported by kinetic resolution. Chiral triazoles were isolated in high yield with limiting alkyne (up to 97:3 enantiomeric ratio (er)). A range of substrates were tolerated (>30 examples), and the reaction was scaled to >1 g. The er of a triazole product could be enhanced by recrystallization and the recovered scalemic azide could be racemized and recycled. Recycling the azide allows efficient use of the undesired azide enantiomer.

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Northern pig‐tailed macaques (Macaca leonina) maintain superior CD4⁺ T‐cell homeostasis during SIVmac239 infection

Abstract: Gradual depletion of CD4 T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4 T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection.

Cited by 10 publications

References 9 publications

Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina)

Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina)

寄生虫逃避免疫功能不全宿主

Kinetic Resolution of Cyclic Secondary Azides, Using an Enantioselective Copper-Catalyzed Azide–Alkyne Cycloaddition

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Northern pig‐tailed macaques (Macaca leonina) maintain superior CD4+ T‐cell homeostasis during SIVmac239 infection

Abstract: Gradual depletion of CD4 T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4 T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection.

Cited by 10 publications

References 9 publications

Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina)

Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina)

寄生虫逃避免疫功能不全宿主

Kinetic Resolution of Cyclic Secondary Azides, Using an Enantioselective Copper-Catalyzed Azide–Alkyne Cycloaddition

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Northern pig‐tailed macaques (Macaca leonina) maintain superior CD4⁺ T‐cell homeostasis during SIVmac239 infection