“…In addition, approximately 60%–80% of memory CD4 + T cells in the gastrointestinal tract are depleted within days of HIV and simian immunodeficiency virus (SIV) infection ( Veazey, 2019 ). Both HIV/SIV infections are also associated with structural and functional impairment of gut mucosal tissue ( Song et al, 2018 ; Zhang et al, 2016; Zhang et al, 2019 ). For instance, during infection, intestinal villi become flat and sucrase activity is reduced ( Brenchley & Douek, 2008 ), with disruption of the intestinal epithelial barrier leading to microbial translocation and chronic immune activation ( Somsouk et al, 2015 ), which can further accelerate and exacerbate HIV infection.…”