Norovirus infection among children with acute gastroenteritis in Recife, Brazil: disease severity is comparable to rotavirus gastroenteritis

Nakagomi, Toyoko; Correia, Juliana Mendes; Nakagomi, Osamu; Montenegro, Fernanda; Cuevas, Luís E.; Cunliffe, Nigel A.; Hart, C. A.

doi:10.1007/s00705-008-0060-7

Cited by 31 publications

(18 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are consistent with recent studies that describe RV as the most prevalent and NoV as the second most important viral agent causing gastroenteritis in children (RV 16.6-71.4%; NoV 12-17.3%). [31][32][33][34][35] The NoV and SaV prevalence determined in the current study is higher than previously estimated in the same region, 17 which could be attributed to the more sensitive realtime RT-PCR detection method applied. NoVs were detected only in children up to 2 years old (median age 8 months), which is in agreement with studies in Brazil and Nicaragua where more frequent NoV infections in children ≤2 years old were reported.…”

Section: Discussioncontrasting

confidence: 76%

Emerging norovirus GII.4 2008 variant detected in hospitalised paediatric patients in South Africa

Mans

Villiers

Plessis

et al. 2010

Journal of Clinical Virology

View full text Add to dashboard Cite

a b s t r a c tBackground: Noroviruses (NoVs) are important enteric pathogens that cause gastroenteritis worldwide. The first documented NoV outbreaks in South Africa (SA) were described in 1993. The current NoV prevalence and circulating genotypes are unknown. SA lacks NoV outbreak reporting systems and therefore the number and impact of NoV infections is underestimated. Objectives: This study aimed to determine the prevalence and genetic diversity of NoV infections in hospitalised paediatric patients with gastroenteritis in SA during 2008. Study design: Stool specimens referred for virological analysis from hospitalised children ≤13 years, with gastroenteritis, were screened for rotavirus, human adenovirus and human astrovirus by enzyme immunoassay and for NoV genogroup I (GI), II (GII) and sapovirus by real-time RT-PCR. NoV strains were genotyped, and variants identified, based on sequence and phylogenetic analyses of the 5 end or the full length of the capsid gene, respectively. Results: Rotavirus was the most prevalent virus detected in 24.2% (61/252) of specimens, followed by NoV in 14.3% (35/245) and adenovirus, astrovirus and sapovirus in 9.6%, 6.7% and 4% of specimens, respectively. NoVs were only detected in children ≤2 years. The GII NoVs (89%) predominated and eight types were identified with GII.4 (43%) detected most frequently. The emerging 2008 GII.4 variant represented 80% of the GII.4 strains. Conclusions: A diverse range of NoV genotypes were identified in hospitalised children with gastroenteritis. The 2008 GII.4 variant was the most frequently detected strain in the study. This is the first report of NoV GII.4 viruses in SA.

show abstract

Section: Discussioncontrasting

confidence: 76%

Emerging norovirus GII.4 2008 variant detected in hospitalised paediatric patients in South Africa

Mans

Villiers

Plessis

et al. 2010

Journal of Clinical Virology

View full text Add to dashboard Cite

show abstract

“…However, a number of previous studies, most of them carried out in developing countries, have found no significant differences between the severity of rotavirus and norovirus infections [15][16][17]. In the current study which is the first in Lebanon, rotavirus infection is shown to be the major cause of severe acute gastroenteritis requiring hospitalization in infants and children followed by norovirus GII infection.…”

Section: Discussioncontrasting

confidence: 49%

First description of gastroenteritis viruses in Lebanese children: A pilot study

Al-Ali¹,

Chehadeh²,

Hamzé³

et al. 2011

Journal of Infection and Public Health

View full text Add to dashboard Cite

Human enteric viruses are important causes of acute gastroenteritis in infants and children. The role of rotaviruses, adenoviruses, human caliciviruses and astroviruses in the development of severe acute gastroenteritis requiring hospitalization of infants and young children in North Lebanon was investigated. Stool specimens collected between April and May 2010 from 79 Lebanese infants and children hospitalized for severe acute gastroenteritis, were screened for enteric viruses by immunoassays and internally controlled multiplex PCR assay. Out of 79 stool samples, 38 (48%) were positive for rotavirus, and 5 (6%) were positive for norovirus genogroup II. Enteric adenoviruses, sapoviruses and human astroviruses were not detected. Children with severe rotavirus gastroenteritis were younger than those with severe norovirus gastroenteritis. These results highlight the importance of rotavirus and norovirus as causes of severe gastroenteritis in Lebanese children, and the need to incorporate routine screening tests for norovirus infection in clinical settings.

show abstract

“…Unlike the results of this study, Ferreira et al (2012) in the states of Rio de Janeiro and Ribeiro et al (2008) Espírito Santo identified this pathogen as the major viral agent in cases of gastrointestinal infections. Additionally, a study by Nakagomi et al (2008) identified NoV in 15% of samples from the municipality of Recife, with clinical severity similar to that for RV, while in the municipality of São Paulo, Castilho et al (2006) reported 33% positive cases of NoV and Siqueira et al (2013a) found 36.5% of positive samples in the municipality of Belém.…”

Section: Discussionmentioning

confidence: 80%

Acute gastroenteritis and enteric viruses in hospitalised children in southern Brazil: aetiology, seasonality and clinical outcomes

Raboni

Damasio

Ferreira

et al. 2014

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

Viral acute gastroenteritis (AG) is a significant cause of hospitalisation in children younger than five years. Group A rotavirus (RVA) is responsible for 30% of these cases. Following the introduction of RVA immunisation in Brazil in 2006, a decreased circulation of this virus has been observed. However, AG remains an important cause of hospitalisation of paediatric patients and only limited data are available regarding the role of other enteric viruses in these cases. We conducted a prospective study of paediatric patients hospitalised for AG. Stool samples were collected to investigate human adenovirus (HAdV), RVA, norovirus (NoV) and astrovirus (AstV). NoV typing was performed by nucleotide sequencing and phylogenetic analysis. From the 225 samples tested, 60 (26%) were positive for at least one viral agent. HAdV, NoV, RVA and AstV were detected in 16%, 8%, 6% and 0% of the samples, respectively. Mixed infections were found in nine patients: HAdV/RVA (5), HAdV/NoV (3) and HAdV/NoV/RVA (1). The frequency of fever and lymphocytosis was significantly higher in virus-infected patients. Phylogenetic analysis of NoV indicated that all of these viruses belonged to genotype GII.4. The significant frequency of these pathogens in patients with AG highlights the need to routinely implement laboratory investigations.

show abstract

Norovirus infection among children with acute gastroenteritis in Recife, Brazil: disease severity is comparable to rotavirus gastroenteritis

Cited by 31 publications

References 18 publications

Emerging norovirus GII.4 2008 variant detected in hospitalised paediatric patients in South Africa

Emerging norovirus GII.4 2008 variant detected in hospitalised paediatric patients in South Africa

First description of gastroenteritis viruses in Lebanese children: A pilot study

Acute gastroenteritis and enteric viruses in hospitalised children in southern Brazil: aetiology, seasonality and clinical outcomes

Contact Info

Product

Resources

About