Norovirus in Latin America

O’Ryan, Miguel; Riera-Montes, Margarita; Lopman, Benjamin A.

doi:10.1097/inf.0000000000001369

Cited by 38 publications

(36 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar data was reported in the US and in Brazil [31,32]. In our study, norovirus surpassed rotavirus as a leading cause of AGE, in similar fashion as reported in several industrialized and middle-income countries, including US, Brazil and Peru [28,[33][34][35][36]. This is in contrast with data reported from Africa and South East Asia where rotavirus, Cryptosporidium, ETEC, and Shigella, were the most common enteric pathogens associated with AGE [3].…”

Section: Discussionsupporting

confidence: 89%

Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study

Farfán-García¹,

Imdad

Zhang

et al. 2020

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Background Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low-and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. coli pathotypes. Methodology/Principal findings This was a prospective, matched for age, case-control study to assess the etiology of moderate to severe AGE in children less than 5 years of age in Bucaramanga, Colombia, South America. We tested for 24 pathogens using locally available diagnostic testing, including stool culture, polymerase chain reaction, microscopy and enzyme-linked immunoassay. Adjusted attributable fractions were calculated to assess the association between AGE and each pathogen in this study population. The study included 861 participants, 431 cases and 430 controls. Enteric pathogens were detected in 71% of cases and in 54% of controls (p = <0.001). Co-infection was identified in 28% of cases and in 14% of controls (p = <0.001). The adjusted attributable fraction showed that Norovirus GII explained 14% (95% CI: 10-18%)

show abstract

Section: Discussionsupporting

confidence: 89%

Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study

Farfán-García¹,

Imdad

Zhang

et al. 2020

PLoS Negl Trop Dis

View full text Add to dashboard Cite

show abstract

“…[ 16 , 17 ] Poor surveillance about NoV and the tendency of people not to use medical services for mild diseases such as gastroenteritis caused by NoV could cause the underestimation of the prevalence in developing countries. Even in this situation, we found much higher estimates of NoV prevalence than those reported in Africa (11%) [ 21 ] and Latin America (15%), [ 22 ] indicating that the other regions targeted in the present study (i.e., Asia and the Middle East) probably have a higher prevalence.…”

Section: Discussioncontrasting

confidence: 79%

“…A possible reason for the difference between our finding and the previous finding is that we stratified country setting by income instead of WHO mortality stratum, [ 20 ] and high-income countries were not included in the final analysis. This is supported by O’Ryan et al [ 22 ] estimating that NoV prevalence in Latin America was 15% in the community (95% CI: 11–21%), 14% in outpatient settings (95% CI: 10–19%), and 16% in hospital settings (95% CI: 12–21%).…”

Section: Discussionmentioning

confidence: 57%

A systematic review and meta-analysis of the prevalence of norovirus in cases of gastroenteritis in developing countries

et al. 2017

View full text Add to dashboard Cite

show abstract

“…RV infection commonly affects children <5 years of age, but has declined in many countries since the introduction of universal RV vaccination program [ 4 ]. NV infection has therefore emerged as the leading cause of AGE in this age group [ 5 , 6 ] with ADV infection not far behind [ 7 , 8 ]. Nevertheless, the etiology of a significant proportion of gastrointestinal illness remains undetermined especially in developing countries [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Human enteroviruses associated with and without diarrhea in Thailand between 2010 and 2016

et al. 2017

View full text Add to dashboard Cite

Non-bacterial acute gastroenteritis (AGE) associated with virus infection affects individuals living in developing countries, especially children. To investigate whether shedding of certain human enterovirus (EV) is more frequently detected in the stool of individuals with AGE of unknown etiology than individuals without AGE symptoms, we tested fecal samples collected from 2,692 individuals with diarrhea between January 2010 and December 2016. Samples were tested for rotavirus, norovirus, and EV by reverse-transcription polymerase chain reaction (RT-PCR) and adenovirus by PCR. EV-positive samples were subjected to sequencing and phylogenetic analysis to identify EV species and types. Findings were compared to EV found in 1,310 fecal samples from individuals without AGE who were diagnosed with hand, foot, and mouth disease (HFMD). While the majority of viruses identified in AGE consisted of human rotavirus (22.7%), norovirus (11.4%) and adenovirus (9.3%), we identified EV (6.2%) belonging mainly to species B, C, and rhinovirus. In contrast, >92% of EV found without AGE symptoms belonged to species A. Although AGE symptoms are not often attributed to EV infection, EV was associated with diarrhea of unknown etiology at least in 3.4% of AGE cases. While CV-A6 was most likely to be found in stools of HFMD patients, rhinovirus A and C were the two most common EV species associated with AGE. Elucidating group-specific EV infection in diseases with and without AGE will be useful in assisting identification, clinical management, and the surveillance of EV infection in the community.

show abstract

Norovirus in Latin America

Abstract: Noroviruses are associated with almost 1 out of every 6 hospitalizations because of acute diarrhea in children younger than 5 years of age in Latin America.

Cited by 38 publications

References 23 publications

Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study

Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study

A systematic review and meta-analysis of the prevalence of norovirus in cases of gastroenteritis in developing countries

Human enteroviruses associated with and without diarrhea in Thailand between 2010 and 2016

Contact Info

Product

Resources

About