Norovirus Highly Prevalent Cause of Endemic Acute Diarrhea in Children in the Peruvian Amazon

Yori, Pablo Peñataro; Schwab, Kellogg J.; Gilman, Robert H.; Nappier, Sharon P.; Portocarrero, Daniel Velasquez; Black, Robert E.; Olórtegui, Maribel Paredes; Hall, Eric R.; Moe, Christine L.; León, Juan S.; Cama, Vita A.; Kosek, Margaret

doi:10.1097/inf.0b013e3181a24730

Cited by 25 publications

(30 citation statements)

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“…GII.4/2006b was the most prevalent GII.4 variant found in 25.4% of all AGE cases, followed by GII.4/ 2008 and GII.4/2010. Three rotavirus G genotypes (G2, G3, and G9) and two P genotypes (P [8] and P [4]) were detected ( Table 4). In patients with AGE, the most prevalent types were G3P [8] (44.0%) and G2P [4] (16.0%).…”

Section: Resultsmentioning

confidence: 99%

“…Three rotavirus G genotypes (G2, G3, and G9) and two P genotypes (P [8] and P [4]) were detected ( Table 4). In patients with AGE, the most prevalent types were G3P [8] (44.0%) and G2P [4] (16.0%). Genotype data were available for only one of three non-diarrheal stool samples positive for rotavirus that showed G9P [4].…”

Section: Resultsmentioning

confidence: 99%

“…Before the introduction of rotavirus vaccine, norovirus had emerged in the literature as a major cause of pediatric AGE in Latin American children. 8 Few studies have described norovirus prevalence relative to rotavirus after vaccine introduction. 4,7,30,31 To our knowledge, we are the first to describe norovirus infections in Bolivia.…”

Section: Discussionmentioning

confidence: 99%

“…2 Norovirus and rotavirus are the major causes of diarrheal illness in South American children. [3][4][5][6][7][8][9] Recent data suggest that the relative burden of norovirus versus rotavirus in children with AGE may be changing after widespread adoption of rotavirus vaccine. Relatively little is known of viral etiology of pediatric AGE in low income, high mortality settings after vaccine introduction.…”

Section: Introductionmentioning

confidence: 99%

“…Norovirus GII was identified in 97.8% of norovirus-positive samples; GII.4 was the most common genotype (71.4% of typed specimens). Rotavirus G3P [8] was the most prevalent rotavirus genotype (44.0% of typed specimens) and G2P [4] was second most prevalent (16.0% of typed specimens). This community is likely part of a trend toward norovirus predominance over rotavirus in children after widespread vaccination against rotavirus.…”

mentioning

confidence: 99%

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Burden of Norovirus and Rotavirus in Children After Rotavirus Vaccine Introduction, Cochabamba, Bolivia

McAtee¹,

Webman²,

Gilman³

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. The effectiveness of rotavirus vaccine in the field may set the stage for a changing landscape of diarrheal illness affecting children worldwide. Norovirus and rotavirus are the two major viral enteropathogens of childhood. This study describes the prevalence of norovirus and rotavirus 2 years after widespread rotavirus vaccination in Cochabamba, Bolivia. Stool samples from hospitalized children with acute gastroenteritis (AGE) and outpatients aged 5-24 months without AGE were recruited from an urban hospital serving Bolivia's third largest city. Both viruses were genotyped, and norovirus GII.4 was further sequenced. Norovirus was found much more frequently than rotavirus. Norovirus was detected in 69/201 (34.3%) of specimens from children with AGE and 13/71 (18.3%) of those without diarrhea. Rotavirus was detected in 38/201 (18.9%) of diarrheal specimens and 3/71 (4.2%) of non-diarrheal specimens. Norovirus GII was identified in 97.8% of norovirus-positive samples; GII.4 was the most common genotype (71.4% of typed specimens). Rotavirus G3P [8] was the most prevalent rotavirus genotype (44.0% of typed specimens) and G2P [4] was second most prevalent (16.0% of typed specimens). This community is likely part of a trend toward norovirus predominance over rotavirus in children after widespread vaccination against rotavirus.

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