Nöropatik ağrı aksiyal spondiloartritte gözden kaçan bir semptom mu?

Erdogan, Esra; Türk, İpek

doi:10.17826/cumj.1096777

Cukurova Medical Journal

2022

DOI: 10.17826/cumj.1096777

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Nöropatik ağrı aksiyal spondiloartritte gözden kaçan bir semptom mu?

Esra Erdogan

İpek Türk

Abstract: Amaç: Aksiyal spondiloartitler (axSpA) kronik inflamatuar romatolojik hastalıklardan olup ağrı yaşam kalitelerini etkileyen en sık semptomdur. Literatürde ağrının her zaman inflamasyonla korele olmadığı gösterilmiştir. Bu çalışma ile aksiyal spondiloartrit hastalarında nöropatik ağrının frekansının gösterilmesi ve nöropatik ağrı ile hasta özelliklerinin arasındaki ilişkinin gösterilmesi amaçlanmıştır. Gereç ve Yöntem: Kliniğimizde Ocak- Mart 2019 ayları arasında takip edilen, Assessment of SpondyloArthri… Show more

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2024

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Pain in axial spondyloarthritis: role of the JAK/STAT pathway

Selmi,

Chimenti,

Novelli

et al. 2024

Front. Immunol.

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Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that is characterized by new bone formation in the axial musculoskeletal system, with X-ray discriminating between radiographic and non-radiographic forms. Current therapeutic options include non-steroidal anti-inflammatory drugs in addition to biological disease-modifying anti-rheumatic drugs that specifically target tumor necrosis factor-alpha (TNFα) or interleukin (IL)-17. Pain is the most critical symptom for axSpA patients, significantly contributing to the burden of disease and impacting daily life. While the inflammatory process exerts a major role in determining pain in the early phases of the disease, the symptom may also result from mechanical and neuromuscular causes that require complex, multi-faceted pharmacologic and non-pharmacologic treatment, especially in the later phases. In clinical practice, pain often persists and does not respond further despite the absence of inflammatory disease activity. Cytokines involved in axSpA pathogenesis interact directly/indirectly with the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling cascade, a fundamental component in the origin and development of spondyloarthropathies. The JAK/STAT pathway also plays an important role in nociception, and new-generation JAK inhibitors have demonstrated rapid pain relief. We provide a comprehensive review of the different pain types observed in axSpA and the potential role of JAK/STAT signaling in this context, with specific focus on data from preclinical studies and data from clinical trials with JAK inhibitors.

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Pain in axial spondyloarthritis: role of the JAK/STAT pathway

Selmi,

Chimenti,

Novelli

et al. 2024

Front. Immunol.

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show abstract

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Nöropatik ağrı aksiyal spondiloartritte gözden kaçan bir semptom mu?

Cited by 1 publication

References 26 publications

Pain in axial spondyloarthritis: role of the JAK/STAT pathway

Pain in axial spondyloarthritis: role of the JAK/STAT pathway

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