Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life

Abstract

When evaluating metabolic risks in women with PCOS, androgenic status, especially abdominal obesity and age, should be taken into account, which would allow tailored management of the syndrome from early adulthood on.

ACC/AHA 2017 definition of high blood pressure: implications for women with polycystic ovary syndrome

“…In fact, hyperandrogenism has been implicated in blood pressure dysregulation in patients with PCOS (13,14). However, recent evidence suggests that the higher risk for SAH in women with PCOS is linked to metabolic abnormalities, such as IR and adipose tissue dysfunction, rather than to hyperandrogenism per se (4,6,(35)(36)(37).…”

“…W omen with polycystic ovary syndrome (PCOS) face increased cardiovascular risk when compared with healthy women of the same age. Polycystic ovary syndrome, otherwise characterized by an association between hyperandrogenism and ovulatory dysfunction, is also often associated with obesity (1,2), lipid abnormalities (3,4), insulin resistance (IR) (5), and high blood pressure/systemic arterial hypertension (SAH) (6)(7)(8). The mechanism underlying the increased prevalence of SAH in PCOS has been linked to a series of factors such as obesity in and of itself (9), heart autonomic dysfunction (10)(11)(12), hyperandrogenism (13,14), and IR (15).…”

Is polycystic ovary syndrome associated with risk of female sexual dysfunction? A systematic review and meta-analysis

“…hirsutism, alopecia and acne. In women with PCOS with secondary metabolic disturbances, obesity, insulin resistance and dyslipidaemia are the common consequent comorbidities (Hahn et al, 2005;Jones et al, 2011;De Frene et al, 2015;Pinola et al, 2017). Anovulatory infertility, obesity, hirsutism, alopecia and acne are considered to affect feminine identity, self-esteem and the body image of women with PCOS (Hashemi et al, 2014;Jayasena and Franks, 2014;Noroozzadeh et al, 2017a).…”

Does polycystic ovary syndrome increase the risk of subclinical vascular disease in normal-weight type 1 diabetic women?

“…PCOS was identified if there were 12 or more follicles of 2 to 9 mm in diameter in an ovary and/or the presence of an enlarged ovary (>10 cm 3 ). The ovarian volume, follicle number, and mean follicle diameter in the right and left ovaries were calculated and summarized for both ovaries.…”