Normative data of the urinary bone resorption biomarkers for osteoporosis DPD, CTx and NTx among females in Manipur and its correlation with bone mineral density measured by DEXA scan

Abstract

Introduction: Osteoporosis has become a major public health problem affecting more than 100 million people worldwide. Standard diagnosis depends on measuring bone mineral density (BMD) using a dual energy X-ray absorptiometry (DEXA). Bone turnover markers are metabolic products that mediate bone metabolism and can provide information regarding bone formation or resorption before the structural changes of bone occur. BMD and bone markers complement each other, and provide comprehensive information about a patient's bone status and bone activity. Aim: To find the correlation between selected urinary bone turnover markers and bone mineral density measured by DEXA scan. Materials and Methods: A cross sectional study was conducted among 2700 pre and post-menopausal women with intact ovaries aged between 21 to 70 years in three districts of Manipur. Performance of three urinary markers of bone turnover, i.e., Deoxypyridinoline (DPD), N-telopeptide (NTx) and C-telopeptide (CTx) were assessed and correlated with the bone mineral density (T-score) measured by DEXA scan. Results: Significant correlation was found between DEXA T-score and NTx (r=0.070, p=<0.010), but not for DPD and CTx. Conclusion:It can be concluded that there is significant correlation between DEXA T-score and NTx, but not for DPD and CTx. Clinical Significance: In the management of osteoporosis, bone markers can be used for determining the response to antiresorptive treatment, amongnst which NTx of collagen-I may be suggested to assess bone resorption for Manipuri women.