Normalization of defective monocyte chemotaxis during chemotherapy in patients with small cell anaplastic carcinoma of the lung

Nielsen, H.; Bennedsen, J; Dombernowsky, P

doi:10.1007/bf00199426

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…Also, the histologic type of lung tumor with the lowest levels of macrophage infiltration was shown to correlate with the most pronounced depression of MCR [15]. The concept that it is the presence of the malignant tumor which gives rise to the impaired monocyte locomotor ability is supported by the findings of a normalized MCR in cancer patients after clinically successful surgery [21] or chemotherapy [14]. On the other hand, Kleinerman et al [9] suggested that a direct action of cytostatic drugs on the monocytes could explain some of the beneficial effects on the clinical course.…”

Section: Introductionmentioning

confidence: 89%

Monocyte chemotaxis in patients with nonseminomatous testicular carcinoma

Nielsen

Rørth²,

Bennedsen

1985

Cancer Immunol Immunother

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The chemotactic responsiveness of blood monocytes was tested in 16 patients with nonseminomatous testicular carcinoma before, during, and after chemotherapy. All the patients initially had monocyte chemotaxis within the normal range. No correlation with the histology of the tumor, the clinical stage, or the presence in serum of alpha-fetoprotein and human chorionic gonadotropin was observed. Plasma from the patients did not inhibit the chemotaxis of normal monocytes, and serum from the patients contained no chemotactic factor inhibitor. During intensive chemotherapy with cis-platinum, bleomycin, and vinblastine a reversible defect in chemotaxis occurred without correlation to the development of fever. Two months after the completion of chemotherapy the chemotactic responsiveness was unchanged compared with pretreatment values. In conclusion, this study shows normal monocyte chemotaxis in patients with testicular carcinoma, which is in contrast to reports on a variety of other solid tumors.

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Section: Introductionmentioning

confidence: 89%

Monocyte chemotaxis in patients with nonseminomatous testicular carcinoma

Nielsen

Rørth²,

Bennedsen

1985

Cancer Immunol Immunother

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Synergic in vitro effects of interleukin-2 and τ-interferon on the migration of blood monocytes from control subjects and patients with lung cancer

Vaillant¹,

Martinet²,

Martinet³

1993

Cancer

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Background. Macrophages can play a major role against cancer by exerting their cytotoxic activity against tumor cells. The presence of macrophages in tumor stroma is related to the recruitment of circulating blood monocytes through the release of chemotactic factors by cancer cells. However, fewer blood monocytes from patients with cancer, such as lung cancer, migrate from in vivo and in vitro, compared with blood monocytes control subjects. Methods. Two cytokines, interleukin‐2 (IL‐2) and τ‐interferon (τ‐INF), proposed in the treatment of cancer, were tested for their ability to modulate the migratory response in modified Boyden chemotactic chambers of blood monocytes obtained from control subjects and patients with lung cancer in the presence of two chemotactic factors: N‐formylmethionyl‐leucyl‐phenylalamine and complement fraction C5a (C5a). Results. Incubation with IL‐2 and τ‐INF resulted in a dose‐dependent depression of the migration of blood monocytes from control subjects and patients with lung cancer. IL‐2 depression was induced by IL‐2 concentrations of 105 units/ml, and τ‐IFN effects were measured for concentrations of 100 μ/ml. Furthermore, when low concentrations of IL‐2 were tested in combination with low concentrations of τ‐IFN, dose‐dependent depression of blood monocyte migration occurred. Conclusions. Dose‐dependent depression of blood monocyte migration may modulate the inflammatory component of tumor stroma in patients with lung cancer treated with these cytokines. It may also explain, in part, the high incidence of infections in patients treated with IL‐2.

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The Macrophage and Cancer

Clark¹

1985

Immunological Aspects of Cancer

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Normalization of defective monocyte chemotaxis during chemotherapy in patients with small cell anaplastic carcinoma of the lung

Cited by 5 publications

References 12 publications

Monocyte chemotaxis in patients with nonseminomatous testicular carcinoma

Monocyte chemotaxis in patients with nonseminomatous testicular carcinoma

Synergic in vitro effects of interleukin-2 and τ-interferon on the migration of blood monocytes from control subjects and patients with lung cancer

The Macrophage and Cancer

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