Normal vascular prostacyclin generation in patients with chronic myeloproli ferative disorders

Cortelazzo, Sergio; Viero, Piera; Morelli, Carla; Barbui, Tiziano; Gaetano, Giovanni de

doi:10.1016/0049-3848(85)90129-x

Cited by 2 publications

(1 citation statement)

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“…Cortelazzo and colleagues reported no significant difference in venous PGI2 production between patients with myeloproliferative disorders and controls (44). In our study, patients with clonal thrombocytemia showed lower 6-keto-PGF1α levels, the stable breakdown product of PGI2, than patients with secondary thrombocytosis.…”

Section: Discussioncontrasting

confidence: 50%

The Plasma Levels of Prostanoids and Plasminogen Activator Inhibitor-1 in Primary and Secondary Thrombocytosis

Birdane

Haznedaroğlu

Bavbek

et al. 2005

Clin Appl Thromb Hemost

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An elevated platelet count is a common finding in both hospitalized and ambulatory patients. Thrombosis and bleeding complications are more frequently observed in patients with clonal thrombocytosis than secondary thrombocytosis. The aim of this study was to investigate the behaviors of plasminogen activator inhibitor type 1 (PAI-1), the inhibitor of fibrinolysis; and thromboxane A2 and 6-keto-PGF1 alpha, the products of endoperoxides, in 16 patients affected with clonal thrombocytemia as compared with 16 patients with reactive thrombocytosis and 15 normal controls. In the clonal thrombocytemia group, plasma levels of PAI-1 antigen and activity were significantly higher than both reactive thrombocytosis and control group. Plasma levels of 6-keto-PGF1alpha were significantly higher in the clonal thrombocytemia group than the other two groups and also higher in the reactive thrombocytosis group than the control group, which was also significant. This study confirms that arachidonate metabolism is frequently deranged in patients with thrombocytosis and hypofibrinolysis due to increased PAI-1 plasma levels as shown in the clonal thrombocytosis group. This may explain the thrombotic tendency in myeloproliferative disorders.

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Section: Discussioncontrasting

confidence: 50%