Normal values of fluoride from a defined region of the human iliac crest

Abstract

Summary Normal fluoride concentrations in the human iliac crest are presented based on analyses of bone ash Samples were obtained from 100 cadavers of both sexes The bone samples were all taken from exactly the same skeletal location to allow for direct comparison with samples derived by bioptical methods from living subjects The analyses were carried out on solutions of dried bone ash using an ion-sensitive electrode Statistical treatment of the results shows a positive linear relationship between fluoride content and age.

Hydrogen fluoride and inorganic fluorine compounds (Fluorides) [BAT Value Documentation, 1994]

“…1 mg fluoride/g bone ash. Even without additional industrial exposure the fluoride content of the bone increases physiologically with increasing age (17). The threshold limit value of pathological fluoride exposure in the bone is approx.…”

“…The identification of fluoride in the bones is the only indicator able to recognise chronic fluoride exposure after the end of exposure in every case and before the detection of damage is possible by X-ray examination (31). The determination of the fluoride content in human bones (32) is not a method for routine health surveillance because the necessary samples must be obtained by biopsy (17). Rather, the possible internal fluoride body burden must be determined by other biological indicators, whereby the fluoride analysis in the blood and/or urine samples has proved appropriate for the correlating evaluation of internal fluoride exposure (10,14,33).…”