Normal Sleep and Circadian Rhythms: Neurobiologic Mechanisms Underlying Sleep and Wakefulness

Markov, Dimitri; Goldman, Marina

doi:10.1016/j.psc.2006.09.008

Cited by 73 publications

(58 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Case 1 rats received exposure in the dark period, while in Case 2 they were exposed to 1BP in the light period. It is well-known that 5HT neurons are deeply involved in sleep and circadian rhythm 21) , and the situation of 5HT neurons in the dark period is quite different from that in the light period. 1BP exposure in the dark period seemed to lower the activity of 5HT neurons, while 1BP exposure in the light period seemed to enhance it.…”

Section: Discussionmentioning

confidence: 99%

Alteration of Brain Levels of Neurotransmitters and Amino Acids in Male F344 Rats Induced by Three-week Repeated Inhalation Exposure to 1-Bromopropane

Suda

Honma²,

Miyagawa

et al. 2008

Ind Health

View full text Add to dashboard Cite

The present study investigated the effects of 1-bromopropane (1BP) on brain neuroactive substances of rats to determine the extent of its toxicity to the central nervous system (CNS). We measured the changes in neurotransmitters (acetylcholine, catecholamine, serotonin and amino acids) and their metabolites or precursors in eight brain regions after inhalation exposure to 1BP at 50 to 1,000 ppm for 8 h per day for 7 d per week for 3 wk. Rats were sacrificed at 2 h (Case 1), or at 19 h (Case 2) after the end of exposure. In Case 1, the level of 5-hydroxyindoleacetic acid (5HIAA) was lowered in some brain regions by 1BP exposure. The decrease of 5HIAA in the frontal cortex was statistically significant at 50 ppm 1BP exposure. In Case 2, γ-amino butyric acid (GABA) and taurine were decreased in many brain regions of exposed rats, and a significant decrease of taurine in the midbrain occurred at 50 ppm 1BP exposure. In both cases of 2-h and 19-h intervals from the end of exposure to sacrifice, aspartate and glutamine levels were elevated in many brain regions, but the acetylcholine level did not change in any brain region. Three-week repeated exposure to 1BP produced significantly changes in amino acid contents of rat brains, particularly at 1,000 ppm.

show abstract

Section: Discussionmentioning

confidence: 99%

Alteration of Brain Levels of Neurotransmitters and Amino Acids in Male F344 Rats Induced by Three-week Repeated Inhalation Exposure to 1-Bromopropane

Suda

Honma²,

Miyagawa

et al. 2008

Ind Health

View full text Add to dashboard Cite

show abstract

“…20,21) Recently, it has been reported that the activation of the histamine H 1 receptor has anxiogenic effects. Additionally, a histamine releasing agent, compound 48/80, exhibits angiogenic properties.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Histaminergic System in the Anxiolytic-Like Activities of <i>Morus alba</i> Leaves in Mice

Lee

Kim

Lee

et al. 2013

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The aim of this study was to identify the effects of 85% methanolic extract of Morus alba leaves (EMA), which is a traditional herb, in mice. The effects of EMA on the anxiolytic-like behaviour were studied using the elevated plus maze (EPM) and hole-board test. To elucidate the mode of action of the anxiolytic-like effects of EMA, the mice were subjected to the co-administration of EMA (200 mg/kg, per os (p.o.)) and either antagonist. EMA (at 200 or 400 mg/kg) significantly increased the percentages of time-spent in the open arms and entries into the open arms of the EPM versus vehicle-treated control group (p<0.05). Moreover, in the hole-board test, EMA (200 and 400 mg/kg) significantly increased the number of head-dips versus vehicle-treated control group (p<0.05). However, there were no changes in the locomotor activity and myorelaxant effects in any group compared with the vehicle-treated control group. In addition, the anxiolytic-like effects of EMA were abolished by thioperamide (10 mg/kg, intraperitoneally (i.p.)), which is a histamine H 3 receptor antagonist. Moreover, results from reverse transcription polymerase chain reaction (RT-PCR) also revealed that the amygdalal histidine decarboxylase mRNA expression levels in EMA (200 mg/kg)-treated group were significantly higher than those in the vehicle-treated controls (p<0.05). These results suggest that EMA might prove to be an effective anxiolytic agent and that EMA acts via the histaminergic system in central nerve system. Key words anxiety; Morus alba; elevated plus-maze; histamine; thioperamide Mulberry tree (Morus alba L., Moraceae) is cultivated in China, Japan and Korea and is an important herbal material in traditional Chinese medicine. For example, the root bark of mulberry trees has long been used for anti-inflammatory, diuretic, antitussive, and antipyretic purposes in Oriental medicine.1) Moreover, fruit extract of M. alba was reported to modulate the monoamine oxidase activity during exercise and to promote the capability of physical activities.2) In addition to those herbal materials from M. alba, the leaves of this plant are one of the well-known traditional Chinese medicinal herbs and have been traditionally used to cure or prevent diabetic hyperglycemia.3,4) Based on those traditional usages, researchers reported that nitric oxide synthase positive neurons were decreased by the treatment with M. alba extracts in the various hypothalamic areas in the streptozotocin-induced diabetic rat brain. 4) Interestingly, those hypothalamic areas, including the paraventricular nucleus and ventromedial hypothalamic nucleus are rich in histaminergic neurons originating from the tuberomammillary body.5) These findings suggest a possibility that the leaves of M. alba may affect the activity of the histaminergic nervous system. Moreover, several clinically useful anxiolytics have been found to affect the turnover rate of brain histamine in the rat brain. For example, diazepam inhibits histamine turnover by acting on γ-aminobutyric acid (GABA) A receptors ...

show abstract

“…Anatomically, the SCN has connections with many brain regions [53][54][55]. Of particular interest is its projections to the hippocampus, both directly [55] and indirectly via the locus coeruleus [56], which in turn mediates hippocampal activation [57]. Whether these connections are responsible for the circadian expressions of clock genes in hippocampus, or hippocampal synaptic plasticity is not known.…”

Section: Mechanisms Underlying Circadian Regulation Of Learning and Mmentioning

confidence: 99%

What Role do Circadian Rhythms Play in Learning and Memory?

Mou¹

2016

J Neurol Neurophysiol

View full text Add to dashboard Cite

Circadian rhythmicity in gene expression and physiological process has been observed both in the central nervous system and in the periphery, including the hippocampus. As a center for memory formation and storage, the hippocampus shows circadian rhythmicity in clock gene expression and synaptic plasticity. Circadian variation in performance of hippocampus-dependent memory task suggests a link between clock gene oscillation and behavioral response. Yet the discrepancy in time scale between fast information encoding during memory acquisition and much slower circadian oscillation in cellular processes casts doubt on the underlying mechanism of circadian regulation of learning and memory. This short review suggests that instead of being a modulator of learning process and memory formation, the time-of-day information itself could be integrated as a component of episodic memory for later consolidation and retrieval.

show abstract

Normal Sleep and Circadian Rhythms: Neurobiologic Mechanisms Underlying Sleep and Wakefulness

Cited by 73 publications

References 18 publications

Alteration of Brain Levels of Neurotransmitters and Amino Acids in Male F344 Rats Induced by Three-week Repeated Inhalation Exposure to 1-Bromopropane

Alteration of Brain Levels of Neurotransmitters and Amino Acids in Male F344 Rats Induced by Three-week Repeated Inhalation Exposure to 1-Bromopropane

Involvement of Histaminergic System in the Anxiolytic-Like Activities of <i>Morus alba</i> Leaves in Mice

What Role do Circadian Rhythms Play in Learning and Memory?

Contact Info

Product

Resources

About