Normal Response to Erythropoietin or Hypoxia in Rats Made Anemic with Turpentine Abscess.

Gutnisky, A; Dyke, D. Van

doi:10.3181/00379727-112-27954

Cited by 28 publications

(8 citation statements)

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“…Evidence to evaluate these possibilities is lacking. The ability of cobalt (11), erythropoietin (12), and hypoxemia (12) to correct the anemia of infection is consistent with either explanation.…”

Section: Discussionsupporting

confidence: 61%

“…The animals were killed on the 10th day, heparinized blood (0.5 ml) from each animal placed in a plastic counting vial with an equal volume of heparinized saline, and the radioactivity determined. The 'Fe uptake was calculated as a percentage of the total dose, with the use of a HEMATOCRIT (%) 12 the severity of anemia in the 31 patients (slope -0.0223, correlation coefficient -0.1311). In sharp contrast, the erythropoietin activity in unconcentrated serum was directly related to the severity of anemia in the 14 patients in group II with primary hematopoietic disease (slope -1.5641, correlation coefficient -0.8802) and the 23 patients in group III with iron-deficiency anemia (slope -0.7224, correlation coefficient 0.6836) (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease

Ward¹,

Kurnick²,

Pisarczyk³

1971

J. Clin. Invest.

120

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease

Ward¹,

Kurnick²,

Pisarczyk³

1971

J. Clin. Invest.

120

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“…Experimental studies, however, have shown that the anemia of inflammation or infection can be corrected by the administration of erythropoietin or testosterone without a concomitant increase in serum iron concentration (27,33,34). The supply of erythropoietin or response to erythropoietin, therefore, appears to be the rate-limiting factor in determining red cell production.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Erythropoiesis in the Anemia of Infection, Inflammation, and Malignancy

Zucker¹,

Friedman²,

Lysik³

1974

J. Clin. Invest.

102

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A B S T R A C T A major factor in the anemia of infection, inflammation, and malignancy is a relative failure of the bone marrow to increase erythropoiesis in response to a shortened red cell survival. The possible causes for this diminished marrow response are: (a) a reduced production of erythropoietin, or, (b) impaired bone marrow response to erythropoietin. In this report studies were performed on 6 normals, 13 patients with anemia from infection or inflammation, and 18 patients with anemia caused by advanced malignancy. Serum erythropoietin activity was measured using the posthypoxic, polycythemic mouse assay. Assessment of bone marrow response to erythropoietin was made by measuring '9Fe-heme synthesis in bone marrow suspensions cultured for 3 days with and without the addition of erythropoietin. The results showed that marrow heme synthesis was increased in erythropoietin-treated cultures as compared with saline control cultures by 66± 8% (mean +SE) in normals, 101±10% in patients with infection or inflammation, and 31±5% in malignancy.Serum erythropoietin levels were consistently diminished relative to expected levels for the degree of anemia in the infection-inflammatory group, but not in malignancy.In these patients, plasma inhibitors to the biological activity of erythropoietin were not detected in vitro.These studies suggest that another factor to consider in the anemia of malignancy is a decreased bone marrow response to erythropoietin. In the anemia of infectioninflammation, marrow response to erythropoietin is normal, but serum levels of erythropoietin are decreased relative to the degree of anemia.

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“…Ferrokinetic studies in man (Gutnitsky and Van Dyke, 1963) and in the dog (Feldman, 1978a) indicate that radioiron disappearance is shortened, suggesting that iron supply to the marrow is suboptimal. (A slow or prolonged clearance :ime usually indicates a reduction of erythroid mass.)…”

Section: Marrow Cellular Defectmentioning

confidence: 99%

The anemia of inflammatory disease in the dog I. The nature of the problem

Feldman

Kaneko

1980

Vet Res Commun

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Normal Response to Erythropoietin or Hypoxia in Rats Made Anemic with Turpentine Abscess.

Cited by 28 publications

References 1 publication

Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease

Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease

Bone Marrow Erythropoiesis in the Anemia of Infection, Inflammation, and Malignancy

The anemia of inflammatory disease in the dog I. The nature of the problem

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