Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study

Demırın, Hilmi; Özhan, Hakan; Ucgun, Taner; Celer, Ahmet; Bulur, Şule; Çil, Habip; Güneş, Cemalettin; Yıldırım, Hayriye Ak

doi:10.1016/j.thromres.2011.05.007

Cited by 124 publications

(92 citation statements)

References 21 publications

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“…PDW directly measures variability in platelet size, changes occurring with platelet activation, and suggests the heterogeneity in platelet morphology. [8][9][10][11][12] Platecrit is a measurement of total platelet mass. Platecrit is useful for detecting platelet quantitative abnormalities.…”

Section: Platelet Indicesmentioning

confidence: 99%

Platelet indices evaluation in patients with dengue fever

Mukker

Kiran

2018

Int J Res Med Sci

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Background: Platelet indices (PIs)-Platecrit, mean platelet volume (MPV) and platelet distribution width (PDW)-are a group of platelet parameters obtained as a part of complete blood count using automated hematology analyzers. Evidence suggests that PIs may have diagnostic and prognostic value in febrile thrombocytopenia. This study aims to understand the profile of PIs in dengue fever. Aims and objectives was to study the platelet indices in patients with dengue fever.Methods: The present study is a retrospective observational study conducted in a tertiary hospital in Kerala. Platelet count, mean platelet volume (MPV), platecrit and Platelet distribution width (PDW) along with routine blood parameters hemoglobin(Hb), hematocrit, WBC, Platelet count, serum bilirubin, liver enzymes (AST, ALT) of 123 patients were collected. These 123 patients were grouped into three according to the platelet count (<20000,20000-100000, >100000). All the test results are available in hospital database. This was accessed using inpatient numbers obtained from medical records department of our institution. All analysis was done using free to use software R and values were rounded off to the nearest decimal point. Non normally distributed parameters were expressed as median (IQR). Parameters which did not follow normal distribution were analyzed with Kruskall Wallis test and the values are expressed as mean (SD) and a p value <0.05 was considered statistically significant.Results: Platelet indices PDW (57±13.8 vs. 55.4±6.9, p value 0.001) and MPV (9.2±0.09 vs. 13.8±1.3fL, p value <0.001) values were significantly altered in dengue fever with platelet counts below 20,000 compared to platelet count more than one lakh group. Similarly, the Platelet index (MPVxPDW\PLCxPCT), MPV\PLC, MPV\Platecrit, PDW\PLC and PDW\Platecrit ratio showed statistically significant difference between the different platelet groups.Conclusions: Platelet indices are useful parameters in dengue infection. Other than platelet count, PDW, MPV, platecrit are useful to monitor dengue fever.

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Section: Platelet Indicesmentioning

confidence: 99%

Platelet indices evaluation in patients with dengue fever

Mukker

Kiran

2018

Int J Res Med Sci

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“…Mean MPV value in the adult Turkish population has been determined as 8.9 fl (Demirin et al, 2011). However, there is no definite value for this.…”

Section: Mean Platelet Volume (Mpv)mentioning

confidence: 99%

Prognostic and Predictive Value of Hematologic Parameters in Patients with Metastatic Renal Cell Carcinoma: Second Line Sunitinib Treatment Following IFN-alpha

Dirican¹,

Küçükzeybek²,

Erten³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Previous [12][13][14][15]. Large population studies have shown that MPV values are correlated to the geographical area and population structure [9,[19][20][21] which emphasis the idea that MPV has a genetic determination [22]. There are conflicting data on the relevance of MPV values in determining the cause of thrombocytosis.…”

Section: Discussionmentioning

confidence: 99%

“…Large platelets are more active and have enhanced procoagulant function. There is evidence supporting the idea that large platelets, probably younger and more reactive, have a pathogenic role in arterial and venous thrombosis [8,9]. Platelet size, measured by mean platelet volume (MPV), has been proposed to become marker of platelet activity, as it was found to correlate with in vitro platelet activation [10].…”

Section: Introductionmentioning

confidence: 95%