No abstract

Omentin serum levels were determined to be low in patients with psoriasis. No significant difference was found regarding Val109Asp polymorphism of the omentin gene. To the best of our knowledge, our study is the first clinical study to examine the relationship between psoriasis and omentin in terms of serum and genomic levels.

Objective: The adipocytokines visfatin and omentin have a direct effect on inflammation and endothelial injury. The expression of visfatin is closely associated with the expression of proinflammatory cytokines. Omentin has an anti-inflammatory effect and is inversely associated with coronary artery disease (CAD). The slow coronary flow phenomenon is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease. The pathophysiology of SCF has not been clearly identified, although multiple abnormalities including endothelial dysfunction, atherothrombosis and inflammation have been reported. However, the relationship between visfatin, omentin and SCF is still unknown. In this study, we aimed to investigate the relationship of these adipocytokines with SCF. Methods: The study included slow coronary flow (n=45) and normal coronary flow (n=55) subjects, according to the corrected TIMI frame count, who underwent angiography in the catheterization laboratory of Duzce University. Statistical analyses were performed with SPSS version 12. Results: Visfatin levels were significantly higher in patients with SCF than in controls (p<0.001). Plasma omentin levels were lower in the SCF group than in controls, although without statistical significance. Visfatin, gender and platelet count were significant predictors of SCF in multivariate logistic regression analysis (OR 0.748, 95% CI 0.632---0.886, p=0.01; OR 30.016, 95% CI 4.355---206.8, p=0.01; OR1.028, 95% CI 1.006---1.050, p=0.011, respectively). Conclusion: Adipocytokines such as visfatin and omentin may play a role in the pathogenesis of coronary slow flow. Níveis séricos de visfatina e omentin no fluxo coronário lento ResumoObjetivo: A visfatina e o omentin são adipocitocinas e têm um efeito direto sobre a inflamação e a lesão endotelial. A expressão da visfatina está intimamente associada com a expressão de citoquinas pró-inflamatórias. O omentin tem efeito anti-inflamatório e está inversamente associado com a doença coronária (DC). O fenómeno do fluxo coronário lento (FCL) é um achado angiográfico caracterizada por atraso de opacificação distal na ausência de doença coronária epicárdica significativa. A fisiopatologia do FCL não está claramente identificada, apesar de terem sido relatadas várias alterações, incluindo disfunção endotelial, aterotrombose e inflamação. No entanto, a relação entre visfatina, o omentin e a FCL ainda é desconhecida. Neste estudo, procurou-se investigar essas relações das adipocitocinas com o FCL. Métodos: No estudo foram incluídos indivíduos com fluxo coronário lento (n = 45) e fluxo coronário normal (n = 55) de acordo com a contagem corrigida de quadros TIMI, que necessitavam de angiografia no laboratório de cateterismo da Universidade de Duzce. As análises estatísticas foram realizadas com o programa estatístico SPSS 12. Resultados: Os níveis de visfatina foram significativamente mais altos em pacientes com FCL do que nos do grupo controle (p < 0,001). Os níveis plasmáti...

Adipocytokines such as visfatin and omentin may play a role in the pathogenesis of coronary slow flow.

Amaç: Bu çalışmanın amacı, ankilozan spondilit (AS) hastalarındaki inflamasyon ile nötrofil-lenfosit oranı (NLO) arasındaki ilişkiyi belirlemektir. Yöntem: Ankilozan spondilit tanılı 40 hasta ve 30 sağlıklı gönüllü çalışmaya dahil edildi. Tüm veriler yatan ve poliklinik hasta kayıt veritabanından elde edildi. Tüm olguların Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BAS-DAI), tam kan sayımı (TKS), CRP ve ESH'ı da kapsıyan ayrın-tılı fizik muayene ve laboratuvar bulguları kaydedildi. Lenfosit ve nötrofil sayısı otomatik TKS'nin bir parçası olarak ölçüldü. Bulgular: Akut-faz reaktanı olan CRP ve ESH kontrol grubuna göre hasta grubunda anlamlı olarak daha yüksekti (p 0.05). Sonuç: Bu çalışmada NLO düzeylerinin AS hastalarında sağlıklı bireylere göre anlamlı olarak yüksek olmadığı görüldü. Bu sonuç NLO'nun AS hastalarında sistemik inflamasyonu değerlendirmede uygun bir ölçü birimi olmadı-ğını götermektedir. Bizim elde ettiğimiz bu ön sonuçların daha ileri çalışmalarla tamamlanması gerektiğine inanıyo-ruz. Objective:The purpose of the present study is to determine the association between neutrophil-lymphocyte ratio (NLR) and inflammation in ankylosing spondylitis (AS). Method: Forty patients with ankylosing spondylitis and 30 healthy volunteers were included in the study. All data were obtained from patient registry database from in-patient and out-patient clinics. Detailed physical examination, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were recorded. Complete blood count (CBC), CRP and ESR were performed recorded as laboratory tests in all participants. Lymphocyte and neutrophil counts were measured as part of the automated CBC. Results: The CRP, which is an acute-phase reactant, and ESR were significantly higher in the patient group than those in the control group (p0.05). Conclusion:We observed that NLR levels weren't significantly higher in AS patients compared to healthy individuals. NLR hasn't seem a reasonable measure to detect systemic inflammation in AS patients. We believe that our preliminary results need to be complemented with further studies.Anahtar Kelimeler: Nötrofil-lenfosit oranı, ankilozan spondilit, enflamasyon, hastalık aktivitesi