Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester

Bagot, Catherine; Leishman, Emma; Onyiaodike, Christopher C.; Jordan, Fiona; Freeman, Dilys J.

doi:10.1016/j.thromres.2017.06.027

Cited by 20 publications

(25 citation statements)

References 21 publications

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“…Plasma mean StartTail time, peak thrombin generation and endogenous thrombin potential increased significantly in the first trimester of pregnancy and remained stable in the next two trimesters in a Chinese study [20]. Indeed, an increase of velocity index, peak thrombin and endogenous thrombin potential at the 32 nd day of gestation [21] and at the 43 rd day of gestation [22], compared to pre-pregnancy values, have been observed in two studies done in the U.K. These increased values persisted through to the 59 th day of gestation [22].…”

Section: Coagulation During Pregnancymentioning

confidence: 90%

“…Indeed, an increase of velocity index, peak thrombin and endogenous thrombin potential at the 32 nd day of gestation [21] and at the 43 rd day of gestation [22], compared to pre-pregnancy values, have been observed in two studies done in the U.K. These increased values persisted through to the 59 th day of gestation [22]. Serum levels of estradiol and progesterone were also significantly higher by day 32 of gestation.…”

Section: Coagulation During Pregnancymentioning

confidence: 91%

“…Thromboprophylaxis should start as soon as possible after pregnancy diagnosis in women at clinical risk of thrombosis, as the markers of thrombin generation increase early [22].…”

Section: Thrombin Generation In Women With Recurrent Pregnancy Lossmentioning

confidence: 99%

See 2 more Smart Citations

Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring

2020

Clinical and Experimental Obstetrics & Gynecology

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Section: Coagulation During Pregnancymentioning

confidence: 90%

Section: Coagulation During Pregnancymentioning

confidence: 91%

See 1 more Smart Citation

Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring

2020

Clinical and Experimental Obstetrics & Gynecology

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“…It has been demonstrated that thrombin (resulting from prothrombin) generation increased during pregnancy, starting with the very early stages of the first trimester of normal pregnancy. [8] We did not determine thrombin values, but prothrombin time was within normal limits in healthy pregnant patients.…”

Section: Discussionmentioning

confidence: 99%

Coagulation tests and blood glucose before vaginal delivery in healthy teenage pregnant women compared with healthy adult pregnant women

Covali¹,

Socolov²,

Socolov³

2019

Medicine

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The aim of this study was to compare the coagulation tests and blood glucose levels between healthy teenage pregnant patients and healthy adult pregnant patients just before vaginal delivery In a prospective study, 208 consecutive patients, 3rd trimester healthy pregnant women, underwent blood tests to determine their glucose levels the day before vaginal delivery. Of the 208 patients, 103 also underwent blood coagulation testing performed on the same day. The median values of the coagulation tests (APTT, prothrombin time, INR, prothrombin activity) and blood glucose were very similar in the healthy pregnant teenagers (32.6; 12.9; 1.02; 97.1; 81) compared with that in the healthy adult pregnant patients (32.45; 13.1; 1.01; 97.5; 81.2). Only the median value for fibrinogen was significantly different in healthy pregnant teenagers (348.9 mg/dL) (interquartile range 21.7) compared with that in healthy adult pregnant patients (359.1 mg/dL) (interquartile range 29.88). Significantly different median blood glucose levels also occurred in the <20; 20–29; 30–39; >40 age groups, but the glucose levels were still within normal limits. Even if there was variability between blood values from one age group to another, the median values for coagulation tests and blood glucose were very close in the healthy teenage pregnant patients compared with the median values of the healthy adult pregnant patients, just before vaginal delivery. With very few exceptions, the values for coagulation tests and blood glucose were within normal limits in all age groups of healthy pregnant patients.

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“…In order to reduce the risk of bleeding during prenatal and postpartum period and to maintain placental function during pregnancy and delivery, physiological hypercoagulability accompanies the whole pregnancy time 1 . Abnormal coagulation and fibrinolytic system are likely to lead to a risk of venous thromboembolism (VTE) 50 times higher in pregnant women than in general population, 2 and venous thromboembolism (VTE) is one of the major obstetric causes of maternal mortality 3 …”

Section: Introductionmentioning

confidence: 99%

Trimester‐specific reference intervals of TAT, TM, tPAI‐C and PIC for healthy Chinese pregnant women

Qiao

Zhang

et al. 2020

J of Obstet and Gynaecol

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AimPregnancy is a hypercoagulability state, the aim of this study was to observe the changes of thrombin–antithrombin complex (TAT), thrombomodulin (TM), tissue plasminogen activator‐inhibitor complex (tPAI‐C) and plasmin‐α2–antiplasmin complex (PIC) during pregnancy and establish trimester‐specific reference intervals for Chinese healthy pregnant women.MethodsIn total 190 Chinese healthy pregnant women (first trimester 59 cases, second trimester 60 cases and third trimester 71 cases) were recruited in North China. TAT, TM, tPAI‐C and PIC were processed on Sysmex HISCL 5000 automated chemiluminescence immune detection system. Trimester‐specific reference intervals were established with the 2.5th and 97.5th percentile of the distribution.ResultsThe reference intervals for TAT, TM, tPAI‐C, PIC at trimester 1 were 0.40–3.65 ng/mL, 4.85–8.80 TU/mL, 1.75–6.40 ng/mL, 0.25–1.05 μg/mL, respectively. At trimester 2, the reference intervals were 1.65–8.61 ng/mL, 5.70–9.93 TU/mL, 2.91–7.71 ng/mL, 0.33–2.02 μg/mL, respectively. At trimester 3, the reference intervals were 3.16–12.68 ng/mL, 5.50–14.24 TU/mL, 2.70–10.69 ng/mL, 0.24–1.54 μg/mL, respectively.ConclusionsThe changes of TAT, TM, tPAI‐C, PIC during pregnancy are presented, and trimester‐specific reference intervals for healthy pregnant women are described. The levels of TAT, TM, tPAI‐C were increased gradually from trimester 1 to trimester 3, while the PIC level remains stable during all trimesters.

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Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester

Cited by 20 publications

References 21 publications

Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring

Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring

Coagulation tests and blood glucose before vaginal delivery in healthy teenage pregnant women compared with healthy adult pregnant women

Trimester‐specific reference intervals of TAT, TM, tPAI‐C and PIC for healthy Chinese pregnant women

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