Trimester‐specific reference intervals of TAT, TM, tPAI‐C and PIC for healthy Chinese pregnant women

Abstract

AimPregnancy is a hypercoagulability state, the aim of this study was to observe the changes of thrombin–antithrombin complex (TAT), thrombomodulin (TM), tissue plasminogen activator‐inhibitor complex (tPAI‐C) and plasmin‐α2–antiplasmin complex (PIC) during pregnancy and establish trimester‐specific reference intervals for Chinese healthy pregnant women.MethodsIn total 190 Chinese healthy pregnant women (first trimester 59 cases, second trimester 60 cases and third trimester 71 cases) were recruited in North China. TAT, TM, tPAI‐C and PIC were processed on Sysmex HISCL 5000 automated chemiluminescence immune detection system. Trimester‐specific reference intervals were established with the 2.5th and 97.5th percentile of the distribution.ResultsThe reference intervals for TAT, TM, tPAI‐C, PIC at trimester 1 were 0.40–3.65 ng/mL, 4.85–8.80 TU/mL, 1.75–6.40 ng/mL, 0.25–1.05 μg/mL, respectively. At trimester 2, the reference intervals were 1.65–8.61 ng/mL, 5.70–9.93 TU/mL, 2.91–7.71 ng/mL, 0.33–2.02 μg/mL, respectively. At trimester 3, the reference intervals were 3.16–12.68 ng/mL, 5.50–14.24 TU/mL, 2.70–10.69 ng/mL, 0.24–1.54 μg/mL, respectively.ConclusionsThe changes of TAT, TM, tPAI‐C, PIC during pregnancy are presented, and trimester‐specific reference intervals for healthy pregnant women are described. The levels of TAT, TM, tPAI‐C were increased gradually from trimester 1 to trimester 3, while the PIC level remains stable during all trimesters.

Reference intervals of novel thrombus markers in healthy older Chinese adults

“…Therefore, the trend change of t-PAIC results in this study is in line with expectations. At present, research on the RIs of novel thrombus markers for pregnant women is gradually maturing [30][31][32]. According to Wu's study [30], the levels of TAT, PIC, and t-PAIC were increased from trimester one to trimester three, while PIC remained stable during all trimesters.…”

“…At present, research on the RIs of novel thrombus markers for pregnant women is gradually maturing [30][31][32]. According to Wu's study [30], the levels of TAT, PIC, and t-PAIC were increased from trimester one to trimester three, while PIC remained stable during all trimesters. However, there are currently no reports on the RIs of these markers for the older population.…”