Normal Human Fibroblasts Express Pattern Recognition Receptors for Fungal (1→3)-β-<scp>d</scp>-Glucans

Kougias, Panagiotis; Wei, Duo; Rice, Peter J.; Ensley, Harry E.; Kalbfleisch, John H.; Williams, David L.; Browder, I. William

doi:10.1128/iai.69.6.3933-3938.2001

Cited by 81 publications

(77 citation statements)

References 44 publications

(53 reference statements)

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“…In doing so, murine DC are exquisitely sensitive to the different forms of the fungus, a finding in line with the increasingly recognized importance of PRR in antifungal host defense (67)(68)(69). Considering that phagocytosis of inactivated Aspergillus conidia induced functional maturation of human DC derived from CD54 ϩ progenitors and that ex vivo-generated DC could partially restore the antifungal effector T cell reactivity in vitro in hemopoietic transplantation (70), our findings provide important and novel insights into the key role of DC in the regulation of antifungal immune reactivity, which may go from immunity to autoimmunity and allergy (71).…”

Section: Discussionmentioning

confidence: 65%

Dendritic Cells Transport Conidia and Hyphae ofAspergillus fumigatusfrom the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus

Bozza

Gaziano

Spreca

et al. 2002

The Journal of Immunology

310

284

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Aspergilli are respiratory pathogens and pulmonary infections are usually acquired through the inhalation of conidia, able to reach small airways and the alveolar space where the impaired host defense mechanisms allow hyphal germination and subsequent tissue invasion. The invasive pulmonary aspergillosis is the most common manifestation of Aspergillus fumigatus infection in immunocompromised patients and is characterized by hyphal invasion and destruction of pulmonary tissue. A Th1/Th2 dysregulation and a switch to a Th2 immune response may contribute to the development and unfavorable outcome of invasive pulmonary aspergillosis. Dendritic cells (DC) have a primary role in surveillance for pathogens at the mucosal surfaces and are recognized as the initiators of immune responses to them. In the present study, we assessed the functional activity of pulmonary DC in response to A. fumigatus conidia and hyphae, both in vitro and in vivo. We analyzed mechanisms and receptors for phagocytosis by DC as well as DC migration, maturation, and Th priming in vivo upon exposure to either form of the fungus. We found a remarkable functional plasticity of DC in response to the different forms of the fungus, as pulmonary DC were able to: 1) internalize conidia and hyphae of A. fumigatus through distinct phagocytic mechanisms and recognition receptors; 2) discriminate between the different forms in terms of cytokine production; 3) undergo functional maturation upon migration to the draining lymph nodes and spleens; and 4) instruct local and peripheral Th cell reactivity to the fungus.

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Section: Discussionmentioning

confidence: 65%

Dendritic Cells Transport Conidia and Hyphae ofAspergillus fumigatusfrom the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus

Bozza

Gaziano

Spreca

et al. 2002

The Journal of Immunology

310

284

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“…Additionally, it has been found that glucans can directly modulate the functional activity of human dermal fibroblasts [27]. Prolidase activity has been shown in dermal fibroblasts [28].…”

Section: Discussionmentioning

confidence: 99%

Chitotirosidase and prolidase in tinea pedis: A preliminary study

Doğan¹,

Hayta²

2017

Med-Science

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Dermatophyte infections are superficial fungal infections. Tinea pedis is a dermatophyte infection of the feet and interdigital spaces. An evaluation was made of the chitotriosidase (ChT) concentrations, prolidase activity and the possible association between these biomarkers in tinea pedis. Study subjects were comprised of 42 patients with tinea pedis and 40 healthy subjects. Serum ChT concentrations and prolidase activity were determined in study population. Higher ChT concentrations were found in patients than controls (p < 0.001). We did not find any difference between groups in terms of prolidase activity (p = 0.162). We also did not found any correlation between ChT and prolidase activity. ChT seems to have roles during the inflammatory conditions in patients with tinea pedis. Whereas prolidase activity is not associated with the tinea pedis.

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“…17) Several pattern recognition receptors for -glucans have been identified in neutrophils, macrophages, endothelial cells, and fibroblasts. [18][19][20][21][22][23] When a specific -glucan binds to its cognate receptor, it is rapidly internalized into macrophages, stimulating the transcription of cytokines that have functional roles in fibroblast migration and activation. [24][25][26] In addition to macrophages, normal human dermal fibroblasts also express at least two -glucan binding sites.…”

Section: )mentioning

confidence: 99%

Orally and Topically AdministeredSparassis crispa(Hanabiratake) Improved Healing of Skin Wounds in Mice with Streptozotocin-Induced Diabetes

Yamamoto

Kimura

2013

Bioscience, Biotechnology, and Biochemistry

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Normal Human Fibroblasts Express Pattern Recognition Receptors for Fungal (1→3)-β-d-Glucans

Cited by 81 publications

References 44 publications

Dendritic Cells Transport Conidia and Hyphae ofAspergillus fumigatusfrom the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus

Dendritic Cells Transport Conidia and Hyphae ofAspergillus fumigatusfrom the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus

Chitotirosidase and prolidase in tinea pedis: A preliminary study

Orally and Topically AdministeredSparassis crispa(Hanabiratake) Improved Healing of Skin Wounds in Mice with Streptozotocin-Induced Diabetes

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