Normal Gastric Histology in Helicobacter pylori-Infected Children

Gottrand, Frédéric; Çullu, Fügen; Turck, Dominique; Vincent, P; Michaud, Laurent; Mo, Husson; Martin-Delasalle, E; Jp, Farriaux

doi:10.1097/00005176-199707000-00012

Cited by 48 publications

(31 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was no patient with normal gastric mucosa, contrasting with a previous study in children that reported normal gastric mucosa in 27.5% infected patients while examining fragments taken from antrum and fundus (9) . In addition, the mononuclear infiltrate was more intense than the neutrophilic infiltrate in most biopsies.…”

Section: Discussioncontrasting

confidence: 87%

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Langner

Machado

Patricio

et al. 2009

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -Although Helicobacter pylori infection is prevalent in our country, there are few studies evaluating the associated histological abnormalities in children. Objective -To evaluate the histological features of the gastric mucosa in children and adolescents with Helicobacter pylori gastritis. Methods -One hundred and thirty two gastric biopsies from 22 symptomatic patients infected with H. pylori (14F/8M, median age 10 y 5 mo, age range 2 y 11 mo to 16 y 9 mo) were evaluated. Evaluated gastric regions included: antrum (lesser and greater curvature), corpus (lesser and greater curvature), incisura angularis and fundus. Histological examination was performed according to the Updated Sydney System, and regional scores for polymorphonuclear and mononuclear cell infiltrate as well as bacterial density were generated. Results -Fifteen (68.2%) patients presented H. pylori-chronic active gastritis, six (27.3%) presented antrum-predominant H. pylori-chronic active gastritis, and one (4.5%) presented corpus-predominant H. pylori-chronic active gastritis. Polymorphonuclear cell infiltrate and mononuclear cell infiltrate were observed in 93.9% and 98.5% of the biopsy specimens, respectively. Higher histological scores for polymorphonuclear infiltrate, mononuclear infiltrate, and bacterial density were observed in the gastric antrum. Intestinal metaplasia and gastric atrophy were not identified in any patient. Lymphoid aggregates and lymphoid follicles were observed in the gastric antrum of three (13.6%) and seven (31.8%) patients, respectively, but they were not related to antral nodularity. Conclusions -Chronic active gastritis was observed in all patients with H. pylori infection. However, antral or corporeal predominance was not observed in most patients.

show abstract

Section: Discussioncontrasting

confidence: 87%

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Langner

Machado

Patricio

et al. 2009

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…Interestingly, in the two cases where mixed infection was observed with strains differing in their cag PAI status, the cag PAI ϩ strain appeared to be the minority strain. Since the immune responses of children to H. pylori infection appear to differ from those of adults (14,23,34), it is intriguing to speculate that a functional cag PAI may be detrimental to bacterial colonization or persistence in children while enhancing bacterial survival as the immune response matures. A better understanding of the interaction of cag PAI ϩ strains with the pediatric immune system may provide clues as to why a complete cag PAI uniquely predicted development of pediatric ulcer disease compared to other adult H. pylori virulence gene markers.…”

Section: Discussionmentioning

confidence: 99%

PediatricHelicobacter pyloriIsolates Display Distinct Gene Coding Capacities and Virulence Gene Marker Profiles

Talarico

Gold²,

Fero

et al. 2009

J Clin Microbiol

View full text Add to dashboard Cite

Helicobacter pylori strains display remarkable genetic diversity, and the presence of strains bearing the toxigenic vacA s1 allele, a complete cag pathogenicity island (PAI), cagA alleles containing multiple EPIYA phosphorylation sites, and expressing the BabA adhesin correlates with development of gastroduodenal disease in adults. To better understand the genetic variability present among pediatric strains and its relationship to disease, we characterized H. pylori strains infecting 47 pediatric North American patients. Prevalence of mixed infection was assessed by random amplified polymorphic DNA analysis of multiple H. pylori clones from each patient. Microarray-based comparative genomic hybridization was used to examine the genomic content of the pediatric strains. The cagA and vacA alleles were further characterized by allele-specific PCR. A range of EPIYA motif configurations were observed for the cagA gene, which was present in strains from 22 patients (47%), but only 19 (41%) patients contained a complete cag PAI. Thirty patients (64%) were infected with a strain having the vacA s1 allele, and 28 patients (60%) had the babA gene. The presence of a functional cag PAI was correlated with ulcer disease (P ‫؍‬ 0.0095). In spite of declining rates of H. pylori infection in North America, at least 11% of patients had mixed infection. Pediatric strains differ in their spectrum of strainvariable genes and percentage of absent genes in comparison to adult strains. Most children were infected with H. pylori strains lacking the cag PAI, but the presence of a complete cag PAI, in contrast to other virulence markers, was associated with more severe gastroduodenal disease.

show abstract

“…GOTTRAND et al (8) demonstraram que a infecção pelo Hp em crianças é freqüentemente associada com o aspecto normal da mucosa gástrica à endoscopia, contrariando os achados sempre encontrados na população adulta. A falta de resultados das EEGD em crianças evidencia, portanto, a necessidade da realização da biopsia, mesmo em áreas de mucosa gástrica aparentemente normais (4) .…”

Section: Discussionunclassified

Prevalência de infecção por Helicobacter pylori em crianças avaliadas no Hospital de Clínicas de Porto Alegre, RS, Brasil

Sousa

Luz

Moreira

et al. 2001

Arq. Gastroenterol.

View full text Add to dashboard Cite

INTRODUÇÃOO Helicobacter pylori (Hp) é uma bactéria Gram negativa, microaerófila e espiralada (11,22) , sendo provavelmente o agente da infecção crônica mais comum em seres humanos. O Hp coloniza o estômago e tem sido associado à gastrite, úlcera gástrica e duodenal, câncer e linfoma gástrico (19) . Além disso, há estudos que, embora ainda iniciais, evidenciam a relação do Hp com coronariopatia, rosácea, urticária crônica e retardo de crescimento (6,21,25) . Embora metade da população mundial esteja infectada com este organismo, 80% desses indivíduos permanecem sem nenhuma evidência clínica de doença. Portanto, vários fatores, inclusive a aquisição na infância, o tipo de cepa da bactéria, a predisposição genética do hospedeiro e o meio-ambiente parecem estar relacionados a sua fisiopatogenia (25) . Há discrepâncias nas prevalências de gastrite/úlcera gástrica e duodenite/úlcera duodenal associadas ao Hp entre crianças e adultos em estudos realizados em locais distintos. Na Inglaterra a associação foi de 52% e 60%, respectivamente;

show abstract

Normal Gastric Histology in Helicobacter pylori-Infected Children

Abstract: These data show that H. pylori infection can be associated with a normal gastric histology in children.

Cited by 48 publications

References 30 publications

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

PediatricHelicobacter pyloriIsolates Display Distinct Gene Coding Capacities and Virulence Gene Marker Profiles

Prevalência de infecção por Helicobacter pylori em crianças avaliadas no Hospital de Clínicas de Porto Alegre, RS, Brasil

Contact Info

Product

Resources

About